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Total 144 results found since Jan 2013.

Childhood Arthritis and Rheumatology Research Alliance Consensus Clinical Treatment Plans for Juvenile Dermatomyositis with Persistent Skin Rash.
CONCLUSION: Three consensus CTP were developed for use in children with JDM and persistent skin rash despite complete resolution of muscle disease. These CTP reflect typical treatment approaches and are not to be considered treatment recommendations or standard of care. Using prospective data collection and statistical methods to account for nonrandom treatment assignment, it is expected that these CTP will be used to allow treatment comparisons, and ultimately determine the best treatment for these patients. PMID: 27803135 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - November 3, 2016 Category: Rheumatology Tags: J Rheumatol Source Type: research

7th drug hypersensitivity meeting: part one
Table of contentsOral AbstractsO1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TENDaniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir PirmohamedO2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture?Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel YerlyO3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivityRebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, Davi...
Source: Clinical and Translational Allergy - August 24, 2016 Category: Allergy & Immunology Source Type: research

Isolated gluteal and paravertebral muscle weakness due to anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme a reductase antibody–associated necrotizing autoimmune myopathy
Conclusions: Anti‐HMGCR–associated necrotizing autoimmune myopathy (NAM) can present in a restricted form after cessation of a statin. Biopsy of a symptomatic but uncommonly studied muscle is worthwhile. Muscle Nerve, 2016
Source: Muscle and Nerve - May 25, 2016 Category: Internal Medicine Authors: Nicole M. McGrath, Clinton P. Turner Tags: Case of the Month Source Type: research

Subcutaneous Immunoglobulin in Refractory Juvenile Dermatomyositis
We report a child with steroid-dependent JDM refractory to hydroxychloroquine and subcutaneous methotrexate who experienced systemic reactions to intravenous immunoglobulin and was successfully treated with subcutaneous immunoglobulin. This form of therapy has been shown to be safe, has a very low rate of adverse effects, does not require hospital admission, reduces the number of missed school days, and decreases the costs associated with treatment.
Source: PEDIATRICS - May 11, 2016 Category: Pediatrics Authors: de Inocencio, J., Enriquez-Merayo, E., Casado, R., Gonzalez-Granado, L. I. Tags: Rheumatology/Musculoskeletal Disorders Case Report Source Type: research

Update on the pharmacological treatment of adult myositis
Abstract The management of patients with idiopathic inflammatory myopathy (IIM) remains a challenge given the systemic features beyond active myositis. That is, recognizing the inflammatory arthropathy, varying dermatomyositis rashes, and overt and occult features of interstitial lung disease in addition to myositis adds to the complexity of diagnosis and treatment of IIM. However, clinicians now have available many more immunosuppressive drugs as well as biologic agents for use in patients with myositis and other autoimmune diseases. Here, the use of these agents is reviewed and support based on available published litera...
Source: Journal of Internal Medicine - April 19, 2016 Category: Internal Medicine Authors: C. V. Oddis Tags: Review Source Type: research

Isolated gluteal and paravertebral muscle weakness due to anti‐HMGCR antibody‐associated necrotizing autoimmune myopathy
This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - April 6, 2016 Category: Internal Medicine Authors: Nicole M. McGrath, Clinton P. Turner Tags: Case of the Month Source Type: research

Subcutaneous Immunoglobulin in Refractory Juvenile Dermatomyositis
We report a child with steroid-dependent JDM refractory to hydroxychloroquine and subcutaneous methotrexate who experienced systemic reactions to intravenous immunoglobulin and was successfully treated with subcutaneous immunoglobulin. This form of therapy has been shown to be safe, has a very low rate of adverse effects, does not require hospital admission, reduces the number of missed school days, and decreases the costs associated with treatment.
Source: PEDIATRICS - March 31, 2016 Category: Pediatrics Authors: de Inocencio, J., Enriquez-Merayo, E., Casado, R., Gonzalez-Granado, L. I. Tags: Rheumatology/Musculoskeletal Disorders Case Report Source Type: research

Juvenile Idiopathic Inflammatory Myopathy in a Patient With Dyskeratosis Congenita Due to C16orf57 Mutation
Dyskeratosis congenita (DC) is a rare inherited disorder characterized by reticular skin pigmentation, oral cavity leukoplakia, and nail dystrophy. A variety of noncutaneous (dental, pulmonary, gastrointestinal, neurological, genitourinary, ophthalmic, and skeletal) abnormalities also have been reported. An 8-year-old boy with DC developed juvenile idiopathic inflammatory myopathy. C16orf57 mutation was identified as a genetic cause of DC. Treatment with methylprednisolone was initiated, followed with methotrexate, prednisolone, and high-dose intravenous immunoglobulin treatment. This is the first report on a patient with ...
Source: Journal of Pediatric Hematology Oncology - February 19, 2016 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Treatment of inflammatory myopathy: emerging therapies and therapeutic targets.
Authors: Moghadam-Kia S, Aggarwal R, Oddis CV Abstract Despite the lack of placebo-controlled trials, glucocorticoids are considered the mainstay of initial treatment for idiopathic inflammatory myopathy and myositis-associated interstitial lung disease. Glucocorticoid-sparing agents are often given concomitantly with other immunosuppressive agents, particularly in patients with moderate or severe disease. First-line conventional immunosuppressive drugs include either methotrexate or azathioprine, and when they fail, more aggressive therapy includes mycophenolate mofetil, tacrolimus or cyclosporine, intravenous imm...
Source: Expert Review of Clinical Immunology - February 17, 2016 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Juvenile dermatomyositis and new autoantibodies: Cases and review.
This report highlights the importance of systematic detection and analysis of MSA in diagnosis and characterization of JDM, and describes a new approach that would allow more focused treatments and be a useful predictor of clinical complications and prognosis in JDM-affected subjects. PMID: 26598044 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - November 16, 2015 Category: Pediatrics Authors: Guarella M, Jurquet AL, Retornaz K, Bardin N, Chastang MC, Desjonquere M, Fabien N, Belot A Tags: Arch Pediatr Source Type: research

Treatment for inclusion body myositis.
CONCLUSIONS: Trials of interferon beta-1a and MTX provided moderate-quality evidence of having no effect on the progression of sporadic inclusion body myositis. Overall trial design limitations including risk of bias, low numbers of participants, and short duration make it difficult to say whether or not any of the drug treatments included in this review were effective. An open trial of ATG combined with MTX versus MTX provided very low-quality evidence in favour of the combined therapy based on the percentage change data given. We were unable to draw conclusions from trials of IVIg, oxandrolone, and AZA plus MTX versus MT...
Source: Cochrane Database of Systematic Reviews - July 3, 2015 Category: Journals (General) Authors: Rose MR, Jones K, Leong K, Walter MC, Miller J, Dalakas MC, Brassington R, Griggs R Tags: Cochrane Database Syst Rev Source Type: research

Clinical course and treatment of anti-HMGCR antibody-associated necrotizing autoimmune myopathy
Conclusions: Recognition of HMGCR antibody–associated NAM is important because these patients are responsive to immunosuppression, and early multiagent therapy and a slow and cautious approach to withdrawing steroids may improve outcomes.
Source: Neurology Neuroimmunology and Neuroinflammation - April 2, 2015 Category: Neurology Authors: Ramanathan, S., Langguth, D., Hardy, T. A., Garg, N., Bundell, C., Rojana-Udomsart, A., Dale, R. C., Robertson, T., Mammen, A. L., Reddel, S. W. Tags: Article Source Type: research

Quickly progressive amyotrophy of the thigh: An unusual cause of rapid chondrolysis of the knee
Publication date: Available online 10 February 2015 Source:Joint Bone Spine Author(s): Maeva Ferrari , Karine Louati , Anne Miquel , Anthony Behin , Olivier Benveniste , Jérémie Sellam While rapidly destructive OA is more recognized in hip, we report the case of a 50-year-old woman who presented a rapid chondrolysis in the patellofemoral joint in a context of rapid loss of muscular strength. She had arthralgia, myalgia and proximal muscular deficit of the limbs. Creatine phospho kinase level was elevated and electromyogram exam showed a myogenic syndrome. Neither immune nor visceral disease was highlighted. As we suspe...
Source: Joint Bone Spine - February 13, 2015 Category: Orthopaedics Source Type: research

Drugs in induction and treatment of idiopathic inflammatory myopathies
Abstract Idiopathic inflammatory myopathies (IIM) are a rare disease; so far standardized therapy has not been adequately defined by national or international guidelines or recommendations. Corticosteroids are the mainstay of treatment, but these drugs are burdened by several side effects. Thus, additional treatment based on immunosuppressive agents, especially azathioprine, methotrexate, mycophenolate mofetil and cyclosporine, is often needed. This combinate approach both improves the disease response and allows reduction of the dosage of corticosteroids, decreasing the risk of steroid-related long-term complica...
Source: Autoimmunity Highlights - December 1, 2014 Category: Allergy & Immunology Source Type: research

Cervicobrachial Polymyositis
Conclusions:Cervicobrachial polymyositis presents with predominant or isolated proximal upper limb and neck weakness. It has marked female preponderance and affects neck flexors and extensors and trapezius and deltoid muscles severely. Wrist and finger extensors are also weakened. In a proportion of patients, it is associated with serological markers of autoimmune disorders and interstitial lung disease. In addition to serum creatine kinase, electromyography, and muscle biopsy, magnetic resonance imaging forms a noninvasive adjunct test in the diagnostic process. Because of the pattern of weakness, cervicobrachial polymyos...
Source: Journal of Clinical Neuromuscular Disease - November 22, 2014 Category: Neurology Tags: Original Article Source Type: research