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Total 470 results found since Jan 2013.

Test for Respiratory and Asthma Control in Kids (TRACK): validation of the Portuguese version
ConclusionWe have demonstrated that the Portuguese version of the TRACK questionnaire has satisfactory reliability (internal consistency), adequate criterion validity (compared against GINA levels of control) and constructive validity (compared against respiratory symptoms and medical opinion), showing that it can be a useful tool to discriminate among children with different levels of respiratory symptom control.Trial registrationClinicalTrials.gov:NCT03290222.
Source: World Allergy Organization Journal - December 5, 2018 Category: Allergy & Immunology Source Type: research

Dual exposure to smoking and household air pollution is associated with an increased risk of severe asthma in adults in Brazil
ConclusionsExposure to household pollution is associated with poorer control, greater severity, and poorer pulmonary function; double-exposed individuals have a greater risk of severe asthma and decreased lung function than those exposed only to household pollution.
Source: Clinical and Translational Allergy - December 10, 2018 Category: Allergy & Immunology Source Type: research

Assessment of patch test results carried out during ten years in a city in southern Brazil
Conclusions: Data analysis at the local level is important to define preventive policies.
Source: Anais Brasileiros de Dermatologia - December 12, 2018 Category: Dermatology Source Type: research

Study: 15 percent of babies exposed to Zika before birth had severe abnormalities in first 18 months of life
This study was supported by the National Institutes of Health ’s National Institute of Allergy and Infectious Diseases and National Eye Institute, the Thrasher Research Fund, the Bill and Melinda Gates Foundation Grand Challenges Explorations, and grants from government agencies and other funders in Brazil.
Source: UCLA Newsroom: Health Sciences - December 12, 2018 Category: Universities & Medical Training Source Type: news

Effect of pneumococcal conjugate vaccine introduction on childhood pneumonia mortality in Brazil: a retrospective observational study
Publication date: February 2019Source: The Lancet Global Health, Volume 7, Issue 2Author(s): Cynthia Schuck-Paim, Robert J Taylor, Wladimir J Alonso, Daniel M Weinberger, Lone SimonsenSummaryBackgroundUnderstanding the real-world effect of pneumococcal conjugate vaccines (PCVs) on pneumonia mortality is crucial because of the expectation that increased PCV use will substantially reduce the burden of pneumonia deaths in children younger than 5 years. However, few post-vaccine introduction studies have estimated the benefits of PCV use on childhood mortality and results have been inconsistent. Therefore, we set out to assess...
Source: The Lancet Global Health - January 24, 2019 Category: International Medicine & Public Health Source Type: research

Drug Hypersensitivity Reactions in Children: Are there factors associated with severity?
This study analyzes and describes potential factors associated with severity of DHR in children.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Fabiana A. Nunes, Larissa S. Brand ão, Patricia Guerzet Ayres Bastos, Patrícia Guerzet, Alex E. Lacerda, Cristina F.S.T. Piza, Fernanda Marcelino, Mara Felix, Gladys Queiroz, Daniela Raeder, Luiz Alexandre Rocha, Dirceu Sole, Inês Cristina Camelo-Nunes Source Type: research

Chronic urticaria: diagnosis and therapeutic profiles among patients receiving care at a reference center
Management of Chronic Urticaria (CU) is often a challenge to the Allergist/Immunologist. We aimed to evaluate diagnostic and therapeutic profiles among patients with CU in a UCARE Center in Brazil.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Orlando Trevisan Neto, Juliana A. Sella, Daniel L. Cordeiro, D ébora Corazza Biazin, Guilherme Erlo, Laira Kobarg Cercal Rogério Gomes, Thais N. Mendonça, Janaina Michelle Lima Melo, Mariana P.L. Ferriani, Luisa Karla P. Arruda Source Type: research

Cleaved High Molecular Weight Kininogen Correlates With Hereditary Angioedema Due To C1-Inhibitor Deficiency
Hereditary angioedema with C1 inhibitor deficiency (HAE-C1-INH) is characterized by recurrent episodes of angioedema of cutaneous and submucosal tissue, and gastrointestinal and respiratory tracts. Our group has described the mutation c.351delC in SERPING1 gene, causing HAE type I in a large Brazilian family. Prospective follow-up revealed that there are currently 33 members diagnosed by genetic analysis. We aimed to compare the cleavage of high-molecular-weight kininogen (HMWK) both during HAE attacks and in remission among HAE patents in this family.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Adriana Moreno, Fernanda L. Nunes, Yunan C. Januario, Luana S.M. Maia, Mariana P.L. Ferriani, Marina M. Dias, Davi C. Aragon, Chiara Suffritti, Marco Cicardi, Luis L.P. da Silva, Luisa Karla P. Arruda Source Type: research

High Frequency of S2377X mutation in Filaggrin 2 gene among Brazilian Patients with Atopic Dermatitis: no significant association with severity or persistence of disease
We have previously shown that Brazilian patients with moderate-to-severe Atopic Dermatitis (AD) who remained symptomatic despite anti-inflammatory and immunosuppressant therapy presented filaggrin (FLG) expression comparable to control individuals on skin biopsies (JACI 2016;137,AB144). FLG-2 S2377X mutation has been associated with more persistent AD in children of African ancestry. We have investigated FLG-2 mutations in AD patients and correlated results with clinical parameters.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Wagner Narciso de Campos Source Type: research

Clinical and laboratory evaluation of patients with common variable immunodeficiency (cvid)
CVID comprises a heterogeneous group of diseases and may present with recurrent infections, autoimmunity, chronic pulmonary or gastrointestinal diseases and malignancy. The aim of this study was to evaluate the clinical and laboratory data of patients with CVID attended at a Referral Center of Clinical Immunology in Brazil.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Isabella B. Manhaes, Gabriele F. Camilo, Barbara Luiza B. Cancado, Julio Cesar Gontijo, Renan Augusto Pereira, Mar ília M. Moraes, Luiza M. Marino, Sandro F. Perazzio, Carolina S. Aranda, Juliana Themudo Lessa Mazzucchelli, Dirceu Sole, Beatriz Tavares C Source Type: research

Role of Periostin in Brazilian Patients with Aspirin Exacerbated Respiratory Disease
Aspirin exacerbated respiratory disease (AERD) is characterized by chronic rhinosinusitis with nasal polyps, asthma and hypersensitivity to Aspirin/NSAIDs. Increased levels of periostin have been described in patients with AERD. We evaluated serum periostin in Brazilian patients with AERD, and compared to patients with Perennial Allergic Rhinitis (PAR) and healthy individuals.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Julianne Alves Machado, Daniel L. Cordeiro, Thais Nociti Mendonca, Marcelo Leite, Ricardo Demarco, Ricardo Lessa, Adriana Murashima, Leilane Nogueira, Marina Dias, Adriana S. Moreno, Wilma Lima, Luisa Karla P. Arruda Source Type: research

Occasional digestive hemorrhage in children due to strongyloidiasis: importance of parasitologic testing
RESUMO Objetivo: Descrever um caso incomum de infec ção por Strongyloides stercoralis (S. stercoralis) em paciente de quatro meses de idade e ressaltar a importância do diagnóstico precoce. Descrição do caso: Paciente masculino, procedente e residente de Videira, Santa Catarina, Brasil, nasceu pré-termo, parto cesárea, peso de nascimento 1. 655 g, e permaneceu na Unidade de Terapia Intensiva neonatal e intermediária por 20 dias. Aos quatro meses de idade, começou a evacuar fezes sanguinolentas e foi feita hipótese de alergia à proteína do leite de vaca, em razão da sintomatologia e do uso da fórmula infantil...
Source: Revista Paulista de Pediatria - February 5, 2019 Category: Pediatrics Source Type: research

Changes in substance P levels of inferior turbinate in patients with mucosal contact headache
ConclusionThis study demonstrates the relationship between intranasal contact headaches and increased mucosal substance P levels. We also found that there is no correlation with substance P levels and volume of the inferior turbinate.ResumoIntroduçãoA cefaleia por ponto de contato da mucosa é uma dor direcionada que surge do contato entre o septo nasal e a parede nasal lateral. Evidências corroboram o papel da substância P na cefaleia de contato, de tal forma que a liberação da mesma a partir de terminações nervosas sensoriais possa causar inflamação e alergia.ObjetivoO objetivo deste estudo foi determinar possÃ...
Source: Brazilian Journal of Otorhinolaryngology - February 23, 2019 Category: ENT & OMF Source Type: research

Autophagy Limits Inflammasome During Chlamydia pneumoniae Infection
In this study we found blocking autophagy led to increased CP growth in both macrophages and mouse embryonic fibroblasts. In vivo, loss of the autophagy elongation component ATG16L1 specifically in myeloid cells led to increased mortality in response to CP infection, characterized by greater numbers of neutrophils and dendritic cells, but no change in the CP burden in the lungs. This was accompanied by an increase in inflammasome-active macrophages and IL-1β production. While induction of autophagy in macrophages led to reduced CP growth in vitro, in vivo treatment with rapamycin led to increased mortality of infec...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

B Cell Reconstitution and Influencing Factors After Hematopoietic Stem Cell Transplantation in Children
Nicolaas G. van der Maas, Dagmar Berghuis, Mirjam van der Burg and Arjan C. Lankester* Willem-Alexander Children's Hospital, Department of Pediatrics and Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, Netherlands B cell reconstitution after hematopoietic stem cell transplantation (HSCT) is variable and influenced by different patient, donor, and treatment related factors. In this review we describe B cell reconstitution after pediatric allogeneic HST, including the kinetics of reconstitution of the different B cell subsets and the development of the B cell repertoire, and d...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research