High Frequency of S2377X mutation in Filaggrin 2 gene among Brazilian Patients with Atopic Dermatitis: no significant association with severity or persistence of disease

We have previously shown that Brazilian patients with moderate-to-severe Atopic Dermatitis (AD) who remained symptomatic despite anti-inflammatory and immunosuppressant therapy presented filaggrin (FLG) expression comparable to control individuals on skin biopsies (JACI 2016;137,AB144). FLG-2 S2377X mutation has been associated with more persistent AD in children of African ancestry. We have investigated FLG-2 mutations in AD patients and correlated results with clinical parameters.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research