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Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 28, 2019 Category: Neurology Source Type: research

Neuroimmunology of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis
Conclusion Recent advances in research on HTLV-1 provide better understanding of the molecular pathogenesis and mechanisms of HAM/TSP, and several clinical trials of novel therapies for patients with HAM/TSP have been initiated. However, long-term improvement of motor disability and quality of life still have not been achieved in HAM/TSP patients, and the clinical management remains challenging. Given that HAM/TSP is characterized by activated T-cells in both the periphery and CNS, studies in HAM/TSP will be highly informative for clarifying the pathogenesis of other neuroinflammatory disorders such as multiple sclerosis....
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

Effectiveness of the Bobath concept in the treatment of stroke: a systematic review.
CONCLUSIONS: The Bobath concept is not superior to other approaches for regaining mobility, motor control of the lower limb and gait, balance and activities of daily living of patients after stroke. There is moderate evidence regarding the superior results of other approaches in terms of the motor control and dexterity of the upper limb. Due to the limitations concerning the methodological quality of the studies, further well-designed studies are needed. Implications for rehabilitation The Bobath concept is not superior to other approaches for patients after stroke. The treatments that incorporate overuse of the affected u...
Source: Disability and Rehabilitation - April 23, 2019 Category: Rehabilitation Authors: Díaz-Arribas MJ, Martín-Casas P, Cano-de-la-Cuerda R, Plaza-Manzano G Tags: Disabil Rehabil Source Type: research

What are the perceptions and experiences of falls amongst people with stroke who live in the community?
CONCLUSIONS: This study highlights the perceived negative consequences of falls amongst people with stroke, and the potential contribution of falls to the reduced levels of physical activity often seen following a stroke. Our findings emphasise the need to address falls and balance related self-efficacy alongside strategies to promote safe mobility. A paradigm shift may be needed to highlight potentially modifiable intrinsic risk factors and emphasise the relevance and value of proactive fall prevention to people with stroke. Implications for rehabilitation People with stroke may not report falls or may minimise their sign...
Source: Disability and Rehabilitation - December 4, 2018 Category: Rehabilitation Authors: Munford D, Gunn H Tags: Disabil Rehabil Source Type: research

The relationship between Home-time, quality of life and costs after ischemic stroke: the impact of the need for mobility aids, home and car modifications on Home-time.
CONCLUSIONS: Home-time is a stroke outcome associated with disease severity, healthcare costs and patient wellbeing. Streamlining the discharge process for those requiring extra material support may lead to cost savings and higher quality-of-life. Implications for rehabilitation Delays in discharge from the acute hospital or rehabilitation facility are incurred when patients need extra material support in order to return home. Staff from the discharging facility should assist families by giving timely information on the availability and the cost of wheel chairs and walkers; and explaining and planning the need of a stair l...
Source: Disability and Rehabilitation - October 2, 2018 Category: Rehabilitation Authors: Dewilde S, Annemans L, Lloyd A, Peeters A, Hemelsoet D, Vandermeeren Y, Desfontaines P, Brouns R, Vanhooren G, Cras P, Michielsens B, Redondo P, Thijs V Tags: Disabil Rehabil Source Type: research

Predicting the oxygen cost of walking in hemiparetic stroke patients
ConclusionCwfree was strongly correlated with Sfree, which allowed for the development of a valid Cwfree prediction model. A practitioner could estimate the energy expenditure of walking for a patient without using an indirect calorimeter.
Source: Annals of Physical and Rehabilitation Medicine - July 10, 2018 Category: Rehabilitation Source Type: research

Effect of neuro-orthopaedic surgery for spastic equinovarus foot after stroke. A prospective longitudinal study based on a goal-centered approach.
CONCLUSIONS: This study confirms the efficacy of the neuro-orthopaedic surgical treatment of spastic equinovarus foot after stroke to improve walking capacities and to achieve personal goals in the body function and activity/participation domains of the ICF. PMID: 29904043 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - June 14, 2018 Category: Rehabilitation Authors: Deltombe T, Gilliaux M, Peret F, Leeuwerck M, Wautier D, Hanson P, Gustin T Tags: Eur J Phys Rehabil Med Source Type: research

Predicting the oxygen cost of walking in hemiparetic stroke patients
Conclusion Cwfree was strongly correlated with Sfree, which allowed for the development of a valid Cwfree prediction model. A practitioner could estimate the energy expenditure of walking for a patient without using an indirect calorimeter.
Source: Annals of Physical and Rehabilitation Medicine - March 22, 2018 Category: Rehabilitation Source Type: research

Visual Aids for Patient, Family, and Physician Decision Making About Endovascular Thrombectomy for Acute Ischemic Stroke Clinical Sciences
Conclusions—Visual decision aids are now available to rapidly educate healthcare providers, patients, and families about benefits and risks of endovascular thrombectomy, both when added to IV tPA in tPA-eligible patients and as the sole reperfusion treatment in tPA-ineligible patients.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Ivie Tokunboh, Marta Vales Montero, Matheus Fellipe Zopelaro Almeida, Latisha Sharma, Sidney Starkman, Viktor Szeder, Reza Jahan, David Liebeskind, Nestor Gonzalez, Andrew Demchuk, Michael T. Froehler, Mayank Goyal, Maarten G. Lansberg, Helmi Lutsep, Lee Tags: Ischemia, Revascularization, Treatment, Quality and Outcomes, Ischemic Stroke Original Contributions Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

I ’ ve Been Seeing a Therapist for Years, So Why Am I Not Getting Better?
The answer: We need to address what’s happening inside the office as well as stigma. During the creation of the documentary Going Sane I interviewed Cindy Bulik. She is perhaps the most important researcher on anorexia today. She lives between UNC where she is a distinguished Professor of Eating Disorders and Sweden where she is a professor at the Karolinska Institute. Her current research is exploring genetic influences on anorexia and by the end of our interview she asked if my entire family would be willing to give a sample of blood for the study. She is not the single-minded professor oblivious to social customs tha...
Source: Psych Central - October 10, 2017 Category: Psychiatry Authors: Josh Sabey Tags: Disabilities Disorders Editorials Essays Medications Motivation and Inspiration Policy and Advocacy Psychology Psychotherapy Suicide Treatment Child Development child therapy Clinical Outcome evidence-based practices evidence Source Type: news

Endocrine Disruptors and Health Effects in Africa: A Call for Action
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - August 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Developing a Family of Visual Decision Aids for Intravenous and Endovascular Reperfusion Therapies for Acute Ischemic Stroke (S25.006)
Conclusions:Personograph visual decision aids are a promising approach to rapidly educating patients, family, and healthcare providers on the benefits and risks of the major reperfusion therapies for acute ischemic stroke.Disclosure: Dr. Tokunboh has nothing to disclose. Dr. Vales Montero has nothing to disclose. Dr. Zopelaro has nothing to disclose. Dr. Sharma has nothing to disclose. Dr. Gonzalez has received research support from NIH. Dr. Starkman has received research support from the National Institute of Health, Stryker, Biogen IDEC, Neuravi, Genentech, Covidien, and Astra-Zeneca. Dr. Szeder has nothing to disclose. ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tokunboh, I., Montero, M. V., Zopelaro, M., Sharma, L., Gonzalez, N., Starkman, S., Szeder, V., Jahan, R., Liebeskind, D., Saver, J. Tags: Cerebrovascular Disease and Interventional Neurology: Prehospital and Emergency Department Ischemic Stroke Care Source Type: research

Post-Stroke Disability at a National Referral Hospital in Tanzania (P3.322)
Conclusions:In this low-resource setting, individuals with stroke face a severe burden of disability and high risk of mortality. The majority of participants experienced severe deficits following stroke, as assessed through NIHSS and mRS. While this study may be limited by referral bias, the high toll of disability among this population suggests that post-stroke disability places a significant burden on Tanzanian families and society.Study Supported by:This abstract was made possible with help from the Harvard University Center for AIDS Research (CFAR), an NIH funded program (P30 AI060354), subgrant to F. Mateen.Disclosure...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wibecan, L., Mmbando, T., Grundy, S., Klein, J., Mateen, F., Okengo, K. Tags: Global Health Source Type: research

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