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Condition: Polymyositis

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Total 420 results found since Jan 2013.

Autoimmune myopathies
Scleroderma/systemic sclerosis (Scl/SSc) is a heterogeneous disease which can involve internal organ and cause death. When myopathy occurred in Scl/SSc, it is associated with poor prognosis and with more frequent cardiopulmonary involvement. Because the myositis disease concept is changing and the diagnosis of polymyositis may not exist, it may affect Scl/SSc with ``myositis overlap''. In the current study, we try to elucidate the features of myopathy in Scl/SSc patients mainly from a histopathological point of view.
Source: Neuromuscular Disorders - September 28, 2020 Category: Neurology Authors: Y. Chen, M. Inoue, M. Ogasawara, Y. Saito, L. Indrawati, J. Tanboon, T. Kumutpongpanich, M. Okubo, W. Yohioka, S. Hayashi, S. Noguchi, I. Nishino Source Type: research

Autoimmune myopathies
Inflammatory myopathies consist of heterogenous group of immune-mediated muscle diseases including dermatomyositis, polymyositis and so on. Patients with inflammatory myopathies occasionally have malignancies such as breast, lung, colorectal cancer and nasopharyngeal carcinoma. There have been a few reports of patients with inflammatory myopathy and lymphoma. Herein, we report an unusual case of a 67-year-old male with inflammatory myopathy and diffuse large B cell lymphoma who initially presented with slowly progressive quadriparesis, axial weakness and abnormality in the electromyography and muscle magnetic resonance image (MRI).
Source: Neuromuscular Disorders - September 28, 2020 Category: Neurology Authors: I. Yoo, J. Shin Source Type: research

Accumulation of autophagosome cargo protein p62 is common in idiopathic inflammatory myopathies.
CONCLUSIONS: p62 accumulation is a general response to muscle injury and not a specific marker for sIBM. Also, in sIBM, p62 RNA levels are decreased, suggesting that, in this disease, p62 aggregation is not due to overexpression. PMID: 32896253 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - September 12, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Where are we moving in the classification of idiopathic inflammatory myopathies?
Purpose of review Discoveries of myositis-specific antibodies, transcriptomic signatures, and clinicoseropathological correlation support classification of idiopathic inflammatory myopathies (IIM) into four major subgroups: dermatomyositis, immune-mediated necrotizing myopathy (IMNM), antisynthetase syndrome (ASS), and inclusion body myositis (IBM) whereas leaving polymyositis as a historical nonspecific diagnosis of exclusion. This review summarizes and comments on recent knowledge regarding the major subgroup of IIM. Recent findings Type 1 interferon (IFN1) pathway activation is the most prominent in dermatomyositis...
Source: Current Opinion in Neurology - September 4, 2020 Category: Neurology Tags: MUSCULAR DISEASE: Edited by John Vissing Source Type: research

What is new in idiopathic inflammatory myopathies: Mechanisms and therapies
Satish V Khadilkar, Megha C DhamneAnnals of Indian Academy of Neurology 2020 23(4):458-467 Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of disorders that cause muscle weakness and also have extramuscular manifestations involving various organ systems; namely the lung, skin, heart, and joints. Previously classified broadly as dermatomyositis (DM) and polymyositis now the spectrum of the disease has evolved into more clinical subtypes. There are now five clinicoserological subtypes recognized worldwide DM, antisynthetase syndrome (AS), overlap myositis (OM), immune mediated necrotizing myopathy (IMNM)...
Source: Annals of Indian Academy of Neurology - August 20, 2020 Category: Neurology Authors: Satish V Khadilkar Megha C Dhamne Source Type: research

Late Onset Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) Myopathy Misdiagnosed as Polymyositis
No abstract available
Source: JCR: Journal of Clinical Rheumatology - July 30, 2020 Category: Rheumatology Tags: Images Source Type: research

Inclusion body myositis in the rheumatology clinic
AbstractInclusion body myositis is a rare sporadic inflammatory ‐degenerative myopathy of the elderly. Despite being the commonest type of acquired myopathy after the age of 50, misdiagnosis is extremely common. The most frequent hurdle in identifying new cases is the wrong diagnosis of polymyositis or motor neuron disease. Novel insights into pathogenic mecha nisms have heralded the quest for newer therapeutics as well as drug repurposing in this otherwise progressive disorder.
Source: International Journal of Rheumatic Diseases - July 13, 2020 Category: Rheumatology Authors: Anu Balakrishnan, Rohit Aggarwal, Vikas Agarwal, Latika Gupta Tags: INVITED REVIEW Source Type: research

Juvenile Dermatomyositis and the Inflammatory Myopathies
Semin Neurol DOI: 10.1055/s-0040-1705120The inflammatory myopathies comprise disorders of immune-mediated muscle injury. The histopathology and clinical features help distinguish them. Juvenile dermatomyositis (JDM) is the most common form of myositis in children and adolescents. Children with JDM present with proximal muscle weakness and characteristic rashes. The presentation is similar in children and adults, but JDM is a primary disorder and the adult form often is concerning for a paraneoplastic syndrome. Proximal muscle weakness occurs with dermatomyositis, polymyositis, and immune-mediated necrotizing myopathy, but ...
Source: Seminars in Neurology - April 5, 2020 Category: Neurology Authors: Swafford, Collin Roach, E Steve Tags: Review Article Source Type: research

Clinical and histological features of immune-mediated necrotising myopathy: a multi-centre South Australian cohort study
The idiopathic inflammatory myopathies (IIMs) are a group of systemic autoimmune diseases characterised primarily by muscle inflammation but also potentially accompanied by a range of extra-muscular manifestations. Dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM) constitute well-characterised subtypes of IIM, with the entity of non-specific idiopathic inflammatory myopathy (NSIIM) being more recently described [1]. Whilst these IIM subtypes are distinguished on clinical, serological and histological grounds, they are unified by the presence of a typically prominent intramuscular lymphocytic infiltrate.
Source: Neuromuscular Disorders - February 17, 2020 Category: Neurology Authors: Jessica Day, Sophia Otto, Kathy Cash, Vidya Limaye Source Type: research

Muscle involvement in myasthenia gravis: Expanding the clinical spectrum of myasthenia-myositis association from a large cohort of patients
In conclusion we redefined the clinical spectrum of muscle involvement in MG-IM association, which represent a continuum among 3 main clinical groups: distal, proximal and subclinical muscle involvement. Minimal muscle involvement and focal myositis could be underestimated among myasthenic patients and early aggressive immunotherapy could be required in focal group.Graphical abstract
Source: Autoimmunity Reviews - February 15, 2020 Category: Allergy & Immunology Source Type: research

Inflammatory muscle disease – An update
Publication date: Available online 8 February 2020Source: Best Practice & Research Clinical RheumatologyAuthor(s): Sara Baig, Julie J. PaikAbstractIdiopathic inflammatory myopathies (IIM) are a heterogeneous group of inflammatory myopathies whose common feature is immune-mediated muscle injury. There are distinct subgroups including dermatomyositis (DM), polymyositis (PM), inclusion body myositis, and immune-mediated necrotizing myopathy. Antisynthetase syndrome is also emerging as a distinct subgroup with its unique muscle histopathological characteristic of perifascicular necrosis. While the newly updated EULAR/ACR Class...
Source: Best Practice and Research Clinical Rheumatology - February 9, 2020 Category: Rheumatology Source Type: research

18F-FDG PET/CT in a Patient With Thymoma-Associated Paraneoplastic Polymyositis
A 43-year-old woman presented with progressive muscle weakness and myalgia for 1 month. Laboratory tests revealed the elevation of myogenic enzymes. MRI of the thighs demonstrated a pattern of edema for inflammatory myopathy. Electromyography showed diffuse myopathic disorder, and muscle biopsy indicated polymyositis. 18F-FDG PET/CT was performed to investigate the potential paraneoplastic syndrome and revealed a soft tissue lesion with 18F-FDG avidity in the right anterior mediastinum, as well as diffusely increased activity throughout the body muscles. The patient's symptoms and biochemical abnormalities were gradually r...
Source: Clinical Nuclear Medicine - January 8, 2020 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Differential and quantitative neuroimaging characteristics of inclusion body myositis
Publication date: Available online 12 December 2019Source: Journal of Clinical NeuroscienceAuthor(s): Minori Furuta, Natsumi Furuta, Kazuaki Nagashima, Yukio Fujita, Yoshito Tsushima, Yoshio IkedaAbstractIn clinical settings, it is often difficult to distinguish inclusion body myositis (IBM) from other neuromuscular diseases. In order to clarify clinically useful characteristics for making the differential diagnosis of IBM, we performed clinical, epidemiological, and neuroimaging analyses in patients with various types of neuromuscular disorders. We enrolled 333 patients with myopathy and 12 patients with amyotrophic later...
Source: Journal of Clinical Neuroscience - December 13, 2019 Category: Neuroscience Source Type: research

Strength training and aerobic exercise training for muscle disease.
CONCLUSIONS: The evidence regarding strength training and aerobic exercise interventions remains uncertain. Evidence suggests that strength training alone may have little or no effect, and that aerobic exercise training alone may lead to a possible improvement in aerobic capacity, but only for participants with FSHD. For combined aerobic exercise and strength training, there may be slight increases in muscle strength and aerobic capacity for people with dermatomyositis and polymyositis, and a slight decrease in aerobic capacity and increase in muscle strength for people with juvenile dermatomyositis. More research with rob...
Source: Cochrane Database of Systematic Reviews - December 5, 2019 Category: General Medicine Authors: Voet NB, van der Kooi EL, van Engelen BG, Geurts AC Tags: Cochrane Database Syst Rev Source Type: research