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Condition: von Willebrand Disease

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Total 292 results found since Jan 2013.

Von Willebrand factor antigen levels predict major adverse cardiovascular events in patients with carotid stenosis of the ICARAS study
Von Willebrand factor (VWF) plays an important role in thrombogenesis and mediates platelet adhesion particularly under high shear stress. Such conditions are generally found in stenotic arteries and can eventually cause myocardial infarction or stroke.
Source: Atherosclerosis - September 16, 2019 Category: Cardiology Authors: Katarina D. Kovacevic, Florian J. Mayer, Bernd Jilma, Nina Buchtele, Georg Obermayer, Christoph J. Binder, Andrew D. Blann, Erich Minar, Martin Schillinger, Matthias Hoke Source Type: research

Crosstalk between Platelet and Bacteria: A Therapeutic Prospect.
Abstract Platelets are typically recognized for their roles in the maintenance of hemostasis and vascular wall repair to reduce blood loss. Beyond hemostasis, platelet also plays a critical role in pathophysiological conditions like atherosclerosis, stroke, thrombosis, and infections. During infection, platelets interact directly and indirectly with bacteria through a wide range of cellular and molecular mechanisms. Platelet surface receptors such as GPIbα, FcγRIIA, GPIIbIIIa, and TLRs, etc. facilitate direct interaction with bacterial cells. Besides, the indirect interaction between platelet and bacteria involv...
Source: Current Pharmaceutical Design - September 24, 2019 Category: Drugs & Pharmacology Authors: Yadav VK, Singh PK, Agarwal V, Singh SK Tags: Curr Pharm Des Source Type: research

P13. Abstract Title: Deep Mutational Scan of VWF to Define Mutations that Enhance or Impair Secretion
Von Willebrand Factor (VWF) is a multimeric glycoprotein that recruits platelets to sites of blood vessel injury and serves as a molecular chaperone for coagulation factor VIII (fVIII). Plasma VWF levels are a known risk factor for various thrombotic disorders including VTE, myocardial infarction, and stroke. GWAS studies have identified genetic variants in VWF that contribute to increased and decreased circulating VWF antigen levels. However, it is currently not known why some variants result in high VWF levels while others cause low VWF levels in circulation.
Source: Thrombosis Research - September 30, 2019 Category: Hematology Authors: T. Sparring, C. Kretz, K. Singh, H. Madarati Source Type: research

P7. Abstract Title: Mapping the Interactome of the Metalloprotease ADAMTS13 in Plasma using In-Vitro BioID
Von Willebrand Factor (VWF) is a multimeric plasma protein that tethers platelets to sites of vascular damage, and is an important initiator of blood clotting. ADAMTS13 is a metalloprotease that cleaves VWF to regulate its platelet binding activity. Decreased activity of ADAMTS13 leads to larger VWF multimers resulting in pathological blood clots, such as thrombotic thrombocytopenic purpura (TTP) and stroke. Unlike other circulating proteases, ADAMTS13 is secreted as an active enzyme and is resistant to all known natural protease inhibitors.
Source: Thrombosis Research - September 30, 2019 Category: Hematology Authors: H. Madarati, C. Kretz Source Type: research

N-Terminal Pro B-Type Natriuretic Peptide's Usefulness for Paroxysmal Atrial Fibrillation Detection Among Populations Carrying Cardiovascular Risk Factors
Conclusion: NT-proBNP was elevated in AF cases not identified by ECG; thus, it may be used as a screening biomarker in asymptomatic high-risk populations, with a promising cut-off point of 95 pg/ml that requires further validation.
Source: Frontiers in Neurology - November 28, 2019 Category: Neurology Source Type: research

Bleeding in critical care associated with left ventricular assist devices: pathophysiology, symptoms, and management.
Authors: Leebeek FWG, Muslem R Abstract Chronic heart failure (HF) is a growing health problem, and it is associated with high morbidity and mortality. Left ventricular assist devices (LVADs) are nowadays an important treatment option for patients with end-stage HF not only as a bridging tool to heart transplantation but also, as a permanent therapy for end-stage HF (destination therapy). The use of LVAD is associated with a high risk for bleeding complications and thromboembolic events, including pump thrombosis and ischemic stroke. Bleeding is the most frequent complication, occurring in 30% to 60% of patients, b...
Source: Hematology ASH Education Program - December 7, 2019 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet-reactivity.
CONCLUSIONS: Our data suggest a VWF-mediated role for MMP-13 in the recruitment of platelets to the site of vascular injury and may provide new insights into the association of MMP-13 in atherothrombotic and stroke pathologies. PMID: 31894636 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 1, 2020 Category: Hematology Authors: Howes JM, Knäuper V, Malcor JD, Farndale RW Tags: J Thromb Haemost Source Type: research

Dihydrocapsaicin-induced angiogenesis and improved functional recovery after cerebral ischemia and reperfusion in a rat model
This study investigated the long-term effects of dihydrocapsaicin (DHC)-induced angiogenesis and improved functional outcomes in cerebral ischemia and reperfusion (I/R) rats. Middle cerebral artery occlusion was induced in I/R rats for 2 h, followed by reperfusion. The animals were divided into three groups: sham, I/R + vehicle, and I/R + DHC (10 mg/kg body weight). Fourteen days after I/R injury, the DHC-treated I/R rats had decreased neurological deficit scores, infarct volume, and brain morphology changes. DHC-induced angiogenesis significantly increased the expression of angiogenic factor proteins, such as hypoxia indu...
Source: Journal of Pharmacological Sciences - February 15, 2020 Category: Drugs & Pharmacology Source Type: research

Potent and rapid reversal of the von Willebrand Factor Inhibitor Aptamer BT200.
CONCLUSIONS: The results of this study demonstrate that BT101 is an effective reversal agent for BT200. PMID: 32275107 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - April 9, 2020 Category: Hematology Authors: Zhu S, Gilbert JC, Liang Z, Kang D, Li M, Tarantino PM, Jilma B Tags: J Thromb Haemost Source Type: research

Activated α < sub > IIb < /sub > β < sub > 3 < /sub > on platelets mediates flow-dependent NETosis via SLC44A2
Platelet-neutrophil interactions are important for innate immunity, but also contribute to the pathogenesis of deep vein thrombosis, myocardial infarction and stroke. Here we report that, under flow, von Willebrand factor/glycoprotein Iba-dependent platelet 'priming' induces integrin aIIbb3 activation that, in turn, mediates neutrophil and T-cell binding. Binding of platelet aIIbb3 to SLC44A2 on neutrophils leads to mechanosensitive-dependent production of highly prothrombotic neutrophil extracellular traps. A polymorphism inSLC44A2 (rs2288904-A) present in 22% of the population causes an R154Q substitution in an extracell...
Source: eLife - April 21, 2020 Category: Biomedical Science Tags: Cell Biology Human Biology and Medicine Source Type: research

Tspan18 is a novel regulator of thrombo-inflammation
AbstractThe interplay between thrombosis and inflammation, termed thrombo-inflammation, causes acute organ damage in diseases such as ischaemic stroke and venous thrombosis. We have recently identified tetraspanin Tspan18 as a novel regulator of thrombo-inflammation. The tetraspanins are a family of 33 membrane proteins in humans that regulate the trafficking, clustering, and membrane diffusion of specific partner proteins. Tspan18 partners with the store-operated Ca2+ entry channel Orai1 on endothelial cells. Orai1 appears to be expressed in all cells and is critical in health and disease. Orai1 mutations cause human immu...
Source: Medical Microbiology and Immunology - May 22, 2020 Category: Microbiology Source Type: research

In silico features of ADAMTS13 contributing to plasmatic ADAMTS13 levels in neonates with congenital heart disease
Risk factors contributing to heightened thrombosis in pediatric congenital heart disease (CHD) patients are not fully understood. Among the neonatal CHD population, those presenting with single ventricular physiology are at the highest risk for perioperative thrombosis. The von Willebrand factor and ADAMTS13 interactions have emerged as causative risk factors for pediatric stroke and could contribute to heightened thrombosis in CHD neonates.
Source: Thrombosis Research - May 30, 2020 Category: Hematology Authors: Upendra K. Katneni, David D. Holcomb, Nancy E. Hernandez, Nobuko Hamasaki-Katagiri, Ryan C. Hunt, Haim Bar, Juan C. Ibla, Chava Kimchi-Sarfaty Tags: Full Length Article Source Type: research

Decreased RPM reduces von Willebrand factor degradation with the EVAHEART LVAS: implications for device ‐specific LVAD management
ConclusionsRPM reduction significantly reduced VWF degradation with the centrifugal ‐flow EVAHEART LVAS, an LVAD specifically designed with low shear stress. Different LVADs have unique hematologic footprints and should be managed with device‐specific protocols. Adjustment of RPM to minimize blood trauma while still maintaining physiologic hemodynamics has the potential to decr ease complications related to LVAD‐associated von Willebrand's disease, such as gastrointestinal bleeding and hemorrhagic stroke.
Source: Journal of Cardiac Surgery - July 10, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Carlo R. Bartoli, Jooeun Kang, Tadashi Motomura Tags: ORIGINAL ARTICLE Source Type: research

Blood pressure variability and microvascular dysfunction: the Maastricht Study
Conclusion: Greater systolic and diastolic BPV was associated with higher albuminuria, but not with CSVD features, flicker light-induced retinal arteriolar and venular dilation response, heat-induced skin hyperemia and plasma biomarkers of MVD. This suggests that the microvasculature of the kidneys is most vulnerable to the detrimental effects of greater BPV.
Source: Journal of Hypertension - July 30, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage - clinical aspects Source Type: research

Shenmayizhi Formula Combined with Ginkgo Extract Tablets for the Treatment of Vascular Dementia: A Randomized, Double-Blind, Controlled Trial.
Authors: Zhang H, Cao Y, Pei H, Wang H, Ma L, Wang Z, Diao X, Yang Y, Liu N, Wei Y, Li H Abstract Shenmayizhi formula (SMYZF) has been shown to have an effect on vascular dementia (VaD) in previous studies. The aim of this study was to evaluate whether a combination of SMYZF with Ginkgo extract tablets improves mild-to-moderate VaD. In this 12-week, randomized, double-blind, controlled study, we randomly assigned 196 patients with VaD (aged 50-85 years) to either the SMYZF group (n = 98) or the Ginkgo group (n = 98). All patients received Ginkgo extract tablets as a basic treatment, while the SMYZF group al...
Source: Evidence-based Complementary and Alternative Medicine - August 14, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research