Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet-reactivity.

CONCLUSIONS: Our data suggest a VWF-mediated role for MMP-13 in the recruitment of platelets to the site of vascular injury and may provide new insights into the association of MMP-13 in atherothrombotic and stroke pathologies.
PMID: 31894636 [PubMed - as supplied by publisher]

Source: Thrombosis and Haemostasis - January 1, 2020 Category: Hematology Authors: Howes JM, Knäuper V, Malcor JD, Farndale RW Tags: J Thromb Haemost Source Type: research