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Condition: Stroke
Drug: Hydralazine

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Total 32 results found since Jan 2013.

Renal Denervation Prevents Stroke and Brain Injury via Attenuation of Oxidative Stress in Hypertensive Rats Stroke
Conclusions Our present work provided the first experimental evidence that RD can prevent hypertensive stroke and brain injury, beyond blood pressure lowering, thereby highlighting RD as a promising therapeutic strategy for stroke as well as hypertension.
Source: JAHA:Journal of the American Heart Association - October 14, 2013 Category: Cardiology Authors: Nakagawa, T., Hasegawa, Y., Uekawa, K., Ma, M., Katayama, T., Sueta, D., Toyama, K., Kataoka, K., Koibuchi, N., Maeda, M., Kuratsu, J.-i., Kim-Mitsuyama, S. Tags: Stroke Source Type: research

Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine
Conclusions: Adequate initial dosing of antihypertensive treatment has the potential to reduce time to blood pressure control and possibly time to alteplase therapy. The optimal antihypertensive regimen for controlling blood pressure before alteplase therapy remains unclear.
Source: Journal of Neuroscience Nursing - November 5, 2015 Category: Neuroscience Tags: Pharmacology Update Source Type: research

Abstract 232: Parenteral Antihypertensive Use on the First Day of Hospitalization after Acute Ischemic Stroke: A US Population Study Poster Session II
Conclusion: Approximately 16% of AIS patients receive IV AH medication in the first 24 hours of admission in the US. The rate of early AH treatment has increased over time both overall and among those who did not receive rt-PA. Whether this is due to increasingly aggressive BP treatment by physicians or higher BP on admission among AIS patients is unclear. Contrary to recommendations, nicardipine was used infrequently. More evidence is required to justify specific AH agents for BP treatment in AIS.
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Wang, Y., McDonough, E., Adeoye, O., LaPensee, K., Crothers, T. C., Kleindorfer, D. Tags: Poster Session II Source Type: research

Roles of Hypertension in the Rupture of Intracranial Aneurysms Basic Sciences
Conclusions— Normalization of blood pressure after aneurysm formation prevented aneurysmal rupture in mice. In addition, we found that the inhibition of the local renin–angiotensin system independent from the reduction of blood pressure can prevent aneurysmal rupture.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Tada, Y., Wada, K., Shimada, K., Makino, H., Liang, E. I., Murakami, S., Kudo, M., Kitazato, K. T., Nagahiro, S., Hashimoto, T. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Collateral Blood Flow Availability in Acute Ischemic Stroke: A Case Report (P4.360)
Conclusion: This case supports earlier autopsy specimen dissections indicating most borderzone collaterals linking to adjacent vascular territories are too small to generate the immediate flow needed to spare tissue proximal to a middle cerebral stem occlusion. Assuming acute vasodilation is possible for these vessels, the acute use of vasodilators such as nitroglycerin or hydralazine and calcium-channel blockers like Nimodipine could provide an area for future study.Disclosure: Dr. Rostanski has nothing to disclose. Dr. Lavine has nothing to disclose. Dr. Mohr has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Rostanski, S., Lavine, S., Mohr, J. Tags: Cerebrovascular Case Reports Source Type: research

Augmentation of perfusion with simultaneous vasodilator and inotropic agents in experimental acute middle cerebral artery occlusion: a pilot study
Conclusion Results suggest that perfusion can be augmented in ischemic stroke with norepinephrine and hydralazine. Perfusion augmentation depends on degree of collateralization and territory in question, with some evidence of vascular steal.
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Liu, M., Saadat, N., Jeong, Y. I., Roth, S., Niekrasz, M., Carroll, T., Christoforidis, G. A. Tags: Ischemic stroke Source Type: research

Superoxide dismutase mimetic, tempol, aggravates renal injury in advanced-stage stroke-prone spontaneously hypertensive rats
Objective:The aim of this study was to determine whether antioxidant therapy could relieve hypertension and retard the progression of renal damage in advanced-stage hypertensive rats. Methods:Twenty-four-week-old spontaneously hypertensive stroke-prone rats were treated for 8 weeks with the superoxide dismutase mimetic tempol, low-dose or high-dose candesartan (an angiotensin receptor blocker), or hydralazine, and blood pressure and renal damage were compared. Results:Elevated blood pressure and renal damage with heterogeneity were present after 8 weeks, with greater glomerulosclerosis in the juxtamedullary glomeruli than ...
Source: Journal of Hypertension - February 3, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Oxidative stress Source Type: research

Perindopril increases the swallowing reflex by inhibiting substance P degradation and tyrosine hydroxylase activation in a rat model of dysphagia.
Abstract Patients with hypertension have a high risk of ischemic stroke and subsequent stroke-associated pneumonia. Stroke-associated pneumonia is most likely to develop in patients with dysphagia. The present study was designed to compare the ameliorative effects of different treatments in rat model of dysphagia. Spontaneously hypertensive rats were treated with bilateral common carotid artery occlusion (BCAO) to induce chronic cerebral hypoperfusion causing disorders of the swallowing reflex. Angiotensin-converting enzyme (ACE) inhibitors (perindopril, imidapril and enalapril), an angiotensin II type 1-receptor ...
Source: European Journal of Pharmacology - November 12, 2014 Category: Drugs & Pharmacology Authors: Ikeda JI, Kojima N, Saeki K, Ishihara M, Takayama M Tags: Eur J Pharmacol Source Type: research

Use of Antihypertensive Medications During Delivery Hospitalizations Complicated by Preeclampsia.
CONCLUSION: Use of multiple antihypertensive agents to treat preeclamptic women increased over the study period for women with mild, superimposed, and severe preeclampsia. There was substantial hospital variation in use of antihypertensive agents. This trend was associated with decreased risk of maternal stroke. PMID: 29420396 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - February 5, 2018 Category: OBGYN Authors: Cleary KL, Siddiq Z, Ananth CV, Wright JD, Too G, DʼAlton ME, Friedman AM Tags: Obstet Gynecol Source Type: research

Cerebral cortical microvascular rarefaction in metabolic syndrome is dependent on insulin resistance and loss of nitric oxide bioavailability
ConclusionsFurther analyses revealed that the maintenance of glycemic control and vascular nitric oxide bioavailability were stronger predictors of cerebral cortical MVD in OZR than was prevention of hypertension, and this may have implications for chronic treatment of CVD risk under stroke‐prone conditions.This article is protected by copyright. All rights reserved.
Source: Microcirculation - May 1, 2015 Category: Research Authors: Paul D. Chantler, Carl D. Shrader, Lawrence E. Tabone, Alexandre C. d'Audiffret, Khumara Huseynova, Steven D. Brooks, Kayla W. Branyan, Kristin A. Grogg, Jefferson C. Frisbee Tags: Original Research Source Type: research

Left Ventricular Responses to Acute Changes in Late Systolic Pressure Augmentation in Older Adults.
CONCLUSIONS: Acute changes in late systolic aortic pressure augmentation do not necessarily lead to improved systolic or diastolic function in older people. Preload may be a more important determinant of cardiac performance than afterload in older people with compensated ventricular function. The potential for changes in preload to impair rather than enhance left ventricular systolic and diastolic function in older people warrants further study. CLINICAL TRIALS REGISTRATION: This study is registered at clinicaltrials.gov as NCT00204984. PMID: 23537892 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - March 28, 2013 Category: Cardiology Authors: Sweitzer NK, Hetzel SJ, Skalski J, Velez M, Eggleston K, Mitchell GF Tags: Am J Hypertens Source Type: research

Critical Blood Pressure Threshold Dependence of Hypertensive Injury and Repair in a Malignant Nephrosclerosis Model Kidney
Most patients with essential hypertension do not exhibit substantial renal damage. Renal autoregulation by preventing glomerular transmission of systemic pressures has been postulated to mediate this resistance. Conversely, malignant nephrosclerosis (MN) has been postulated to develop when severe hypertension exceeds a critical ceiling. If the concept is valid, even modest blood pressure (BP) reductions to below this threshold regardless of antihypertensive class (1) should prevent MN and (2) lead to the healing of the already developed MN lesions. Both predicates were tested using BP radiotelemetry in the stroke-prone spo...
Source: Hypertension - September 10, 2014 Category: Cardiology Authors: Griffin, K. A., Polichnowski, A., Litbarg, N., Picken, M., Venkatachalam, M. A., Bidani, A. K. Tags: Animal models of human disease Kidney Source Type: research

Pulmonary vascular response to exercise in symptomatic heart failure with reduced ejection fraction and pulmonary hypertension
ConclusionsEven after thorough decongestion and under continuous afterload reduction, PH secondary to HFrEF is completely reversible in only a minority of patients. Others demonstrate an exercise‐induced PVR increase, associated with impaired right ventricular stroke work, which might be ameliorated by nitric oxide donor support.
Source: European Journal of Heart Failure - December 30, 2014 Category: Cardiology Authors: Frederik H. Verbrugge, Matthias Dupont, Philippe B. Bertrand, Petra Nijst, Lars Grieten, Joseph Dens, David Verhaert, Stefan Janssens, W. H. Wilson Tang, Wilfried Mullens Tags: Original Article Source Type: research

New Quality Measure Seeks to Optimize Cardiovascular Care For African Americans
In recent months, the debate on race and policing in this country has ignited passions and raised important questions. But while headlines have highlighted instances of excessive force by police and the discriminatory treatment of African Americans, the conversation hasn't yet made the logical leap to a discussion around unequal access to care. It is widely accepted in medical literature that African Americans, Hispanics, and the poor are receiving substandard health care. By way of example, the treatment of heart disease should not be a matter of race; it should be a matter of science and medicine. Today, there are thous...
Source: Healthy Living - The Huffington Post - September 2, 2015 Category: Consumer Health News Source Type: news

Focused Update on Pharmacologic Management of Hypertensive Emergencies
AbstractPurpose of ReviewHypertensive emergency is defined as a systolic blood pressure>  180 mmHg or a diastolic blood pressure>  120 mmHg with evidence of new or progressive end-organ damage. The purpose of this paper is to review advances in the treatment of hypertensive emergencies within the last 5 years.Recent FindingsNew literature and recommendations for managing hypertensive emergencies in the setting of pregnancy, stroke, and heart failure have been published.SummaryOral nifedipine is now considered an alternative first-line therapy, along with intravenous hydralazine and labetalol for women presenti...
Source: Current Hypertension Reports - June 8, 2018 Category: Primary Care Source Type: research