Left Ventricular Responses to Acute Changes in Late Systolic Pressure Augmentation in Older Adults.

CONCLUSIONS: Acute changes in late systolic aortic pressure augmentation do not necessarily lead to improved systolic or diastolic function in older people. Preload may be a more important determinant of cardiac performance than afterload in older people with compensated ventricular function. The potential for changes in preload to impair rather than enhance left ventricular systolic and diastolic function in older people warrants further study. CLINICAL TRIALS REGISTRATION: This study is registered at clinicaltrials.gov as NCT00204984. PMID: 23537892 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23537892?dopt=Abstract

Source: American Journal of Hypertension - March 28, 2013 Category: Cardiology Authors: Sweitzer NK, Hetzel SJ, Skalski J, Velez M, Eggleston K, Mitchell GF Tags: Am J Hypertens Source Type: research