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Specialty: Urology & Nephrology
Condition: Hypertension

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Total 232 results found since Jan 2013.

Blood pressure control of hypertensive patients followed in a high complexity clinic and associated variables
CONCLUSION: About half of the hypertensive patients had their blood pressure controlled; clinical variables and target organ damage were associated with the control.PMID:33617623 | DOI:10.1590/2175-8239-JBN-2020-0133
Source: Jornal Brasileiro de Nefrologia - February 22, 2021 Category: Urology & Nephrology Authors: Juliana Chaves Coelho Mayra Cristina da Luz P ádua Guimarães Cassia Lima de Campos Carime Farah Florido Giovanio Vieira da Silva Angela Maria Geraldo Pierin Source Type: research

Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats.
Abstract Non-traditional work schedules, such as shift work, have been associated with numerous health issues including cardiovascular and metabolic disease. These work schedules can chronically misalign environmental timing cues with internal circadian clock systems in the brain and in peripheral organs, leading to dysfunction of those systems and their associated biological processes. Environmental circadian disruption in the kidney may be an important factor in the increased incidence of hypertension and adverse health outcomes in human shift workers. The relationship between renal rhythmicity and injury resili...
Source: Am J Physiol Renal P... - December 28, 2020 Category: Urology & Nephrology Authors: Hill AM, Crislip GR, Stowie A, Ellis I, Ramsey A, Castanon-Cervantes O, Gumz ML, Davidson AJ Tags: Am J Physiol Renal Physiol Source Type: research

Ambulatory hemodynamic patterns, obesity, and pulse wave velocity in children and adolescents
ConclusionsArterial stiffness is higher in overweight and obese children in the co-presence of hypertension. Peripheral and central SBP are the main determinants of 24-h PWV independent of weight status.Graphical abstract
Source: Pediatric Nephrology - October 28, 2020 Category: Urology & Nephrology Source Type: research

Impaired hypertension control in France: What the nephrologist needs to know.
This report, based on the latest French studies and surveys, raises an important warning about the situation in France, discusses the main reasons for these results and offers some suggestions for improvement. Otherwise we risk a dramatic increase in the incidence of myocardial infarction, stroke, dependency and dementia in the coming years. PMID: 33069630 [PubMed - as supplied by publisher]
Source: Nephrologie and Therapeutique - October 14, 2020 Category: Urology & Nephrology Authors: Rubin S, Boulestreau R, Couffinhal T, Combe C, Girerd X Tags: Nephrol Ther Source Type: research

Higher cardiovascular mortality in men with persistent dipstick hematuria
ConclusionsIn men, persistent dipstick hematuria is a significantly risk factor of all-cause mortality, in particular cardiovascular death among general screening participants.
Source: Clinical and Experimental Nephrology - September 21, 2020 Category: Urology & Nephrology Source Type: research

Direct oral anticoagulants in chronic kidney disease: an update
Purpose of review Direct oral anticoagulants (DOACs) are variably eliminated by the kidneys rendering their use potentially problematic in patients with chronic kidney disease (CKD) or necessitating appropriate dose adjustment. Recent findings Both observational and limited randomized trial data for DOACs compared with no treatment or with warfarin for patients with atrial fibrillation on maintenance dialysis were recently published. In a randomized trial in patients on hemodialysis, there was no significant difference in vascular calcification between patients who received rivaroxaban with or without vitamin K2 or vi...
Source: Current Opinion in Nephrology and Hypertension - August 1, 2020 Category: Urology & Nephrology Tags: PHARMACOLOGY AND THERAPEUTICS: Edited by Sankar D. Navaneethan Source Type: research

Premature Stroke Secondary to Severe Hypertension Results from Liddle Syndrome Caused by a Novel SCNN1B Mutation
Conclusions:We identified a novelSCNN1B mutation (c.1849C#x3e;A) in a family affected by LS. Patients with LS, especially those with severe hypertension, should be alert for the occurrence of premature stroke. Timely diagnosis using genetic testing and tailored treatment with amiloride can help LS patients to avoid severe complications.Kidney Blood Press Res
Source: Kidney and Blood Pressure Research - July 22, 2020 Category: Urology & Nephrology Source Type: research

Autophagy in diabetic nephropathy: a review
AbstractDiabetes mellitus (DM) is the leading cause of end stage renal disease. 40% of the patients worldwide will require replacement therapy after 20  years of DM worldwide. Early-stage diabetic nephropathy is characterized by hyperfiltration related to hypeglycemia-induced afferent artery vasodilatation with micro-and macroalbuminuria. Later on, proteinuria with arterial hypertension may appear, culminating in glomerular filtration rate (GFR) d ecline and end stage renal disease. Forty percent of diabetic patients develop microvascular and macrovascular complications, with increased risk among patients with genetic pre...
Source: International Urology and Nephrology - July 12, 2020 Category: Urology & Nephrology Source Type: research

Association between sex hormones and kidney stones: analysis of the National Health and Nutrition Examination Survey
ConclusionsThere appears to be no association between sex hormones and history of kidney stones. Whether there is a more complex interaction of sex hormone levels and the shared association with factors such as metabolic syndrome requires additional investigation. Further studies matching menopausal status for women are necessary to further investigate the potential  relationship between estrogen and kidney stones.
Source: World Journal of Urology - June 4, 2020 Category: Urology & Nephrology Source Type: research

Kidney Case Conference Series: How We Manage Hypertension in a Patient with a Recent Stroke.
PMID: 32393466 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 10, 2020 Category: Urology & Nephrology Authors: Chang TI, Bhalla V Tags: Clin J Am Soc Nephrol Source Type: research

Tubuloreticular inclusions in COVID-19-related collapsing glomerulopathy
A 79-year-old male of African ancestry, with a history of hemorrhagic stroke, monoclonal gammopathy of unknown significance and chronic kidney disease stage 3 due to hypertension was admitted to Bichat hospital on day 1 after the first symptom of COVID-19 (fever). SARS-CoV 2 PCR was positive on nasal swab. At admission urinary dipstick was normal and plasma creatinine was 224 μmol/L. On day 4 plasma albumin was at 29 g/L and proteinuria was 11.4 g per gram of urinary creatinine (80% of albumin).
Source: Kidney International - April 26, 2020 Category: Urology & Nephrology Authors: Fran çois Gaillard, Sophie Ismael, Aurélie Sannier, Hassan Tarhini, Thomas Volpe, Clarisse Greze, Marie Christine Verpont, Ilyass Zouhry, Christophe Rioux, François-Xavier Lescure, David Buob, Eric Daugas Tags: nephrology image Source Type: research

Tubuloreticular inclusions in COVID-19 –related collapsing glomerulopathy
A 79-year-old man of African ancestry, with a history of hemorrhagic stroke, monoclonal gammopathy of unknown significance, and stage 3 chronic kidney disease due to hypertension, was admitted to Bichat Hospital on day 1 after the first symptom of COVID-19 (fever). Severe acute respiratory syndrome coronavirus 2 polymerase chain reaction was positive on nasal swab. At admission, urinary dipstick was normal and plasma creatinine was 224 μmol/l. On day 4 plasma albumin was at 29 g/l and proteinuria was 11.4 g per gram of urinary creatinine (80% of albumin).
Source: Kidney International - April 26, 2020 Category: Urology & Nephrology Authors: Fran çois Gaillard, Sophie Ismael, Aurélie Sannier, Hassan Tarhini, Thomas Volpe, Clarisse Greze, Marie Christine Verpont, Ilyass Zouhry, Christophe Rioux, François-Xavier Lescure, David Buob, Eric Daugas Tags: Nephrology Image Source Type: research

Association of Serum Uromodulin with Death, Cardiovascular Events, and Kidney Failure in CKD.
CONCLUSIONS: Higher serum uromodulin is independently associated with lower risk for mortality, cardiovascular events, and kidney failure in white patients with CKD. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Deutsches Register für Klinische Studien (DRKS; German national database of clinical studies), DRKS00003971. PMID: 32291270 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - April 13, 2020 Category: Urology & Nephrology Authors: Steubl D, Schneider MP, Meiselbach H, Nadal J, Schmid MC, Saritas T, Krane V, Sommerer C, Baid-Agrawal S, Voelkl J, Kotsis F, Köttgen A, Eckardt KU, Scherberich JE, GCKD Study Investigators Tags: Clin J Am Soc Nephrol Source Type: research

PPARγ is a gatekeeper for extracellular matrix and vascular cell homeostasis: beneficial role in pulmonary hypertension and renal/cardiac/pulmonary fibrosis
Purpose of review Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial cell (PAEC) dysfunction and apoptosis, pulmonary arterial smooth muscle cell (PASMC) proliferation, inflammation, vasoconstriction, and metabolic disturbances that include disrupted bone morphogenetic protein receptor (BMPR2)-peroxisome proliferator-activated receptor gamma (PPARγ) axis and DNA damage. Activation of PPARγ improves many of these mechanisms, although erroneous reports on potential adverse effects of thiazolidinedione (TZD)-class PPARγ agonists reduced their clinical use in the past decade. Here, we...
Source: Current Opinion in Nephrology and Hypertension - January 30, 2020 Category: Urology & Nephrology Tags: PATHOPHYSIOLOGY OF HYPERTENSION: Edited by Nancy J. Brown Source Type: research