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RVOT-VTI/PASP Is a Novel Noninvasive Parameter of Pulmonary Artery Compliance and Improves After Treatment with Pulmonary Hypertension-Specific Therapy
Pulmonary artery compliance (PAC) is an independent predictor of mortality in patients with pulmonary hypertension (PH). We have previously shown that the ratio of echocardiography derived right ventricular outflow tract velocity time integral (RVOT-VTI; an estimate of stroke volume) to pulmonary artery systolic pressure (PASP) correlates with PAC measured by right heart catheterization. We sought to determine whether PH-specific therapy improves PAC in patients with pulmonary arterial hypertension (PAH).
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: M.S. Tanna, A. Fox, G.S. Troutman, P.T. Bhattacharya, J.N. Menachem, F. Mao, E.Y. Birati, P.R. Forfia, A. Vaidya, J.A. Mazurek Source Type: research

A Point ‐based Prediction Model for Cardiovascular Risk in Orthotopic Liver Transplantation: The CAR‐OLT Score
Conclusion: The point‐based CAR‐OLT risk score can identify patients at risk for CVD complications after OLT surgery (available at: www.carolt.us). This score may be useful for identification of candidates for further risk stratification or other management strategies to improve CVD outcomes after OLT. This article is protected by copyright. All rights reserved.
Source: Hepatology - July 1, 2017 Category: Internal Medicine Authors: Lisa B. VanWagner, Hongyan Ning, Maureen Whitsett, Josh Levitsky, Sarah Uttal, John T. Wilkins, Michael M. Abecassis, Daniela P. Ladner, Anton I. Skaro, Donald M. Lloyd ‐Jones Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research

Science: Sugar substitute effects not so sweet
Not so sweet. Switching out sucralose or other artificial sweeteners for sugar won ’t help you lose weight and may cause future health problems, researchers who reviewed multiple scientific studies on the topic said. Researchers found a link between consuming artificial sweeteners and higher risks of weight gain, Type 2 diabetes, hypertension, stroke and heart disease, Live Sci ence reported, while weight loss results were minimal. The purpose of the review was to determine the effects of non-nutritive…
Source: bizjournals.com Health Care:Physician Practices headlines - July 17, 2017 Category: American Health Authors: Anne Stych Source Type: news

Associations between Greenness, Impervious Surface Area, and Nighttime Lights on Biomarkers of Vascular Aging in Chennai, India
Conclusion: Greenness, ISA, and NTL were associated with increased SBP, DBP, and cPP, and with reduced FMD, suggesting a possible additional EVA pathway for the relationship between urbanization and increased CVD prevalence in urban India. https://doi.org/10.1289/EHP541 Received: 20 May 2016 Revised: 03 January 2017 Accepted: 23 January 2017 Published: 02 August 2017 Address correspondence to K.J. Lane, Yale School of Forestry and Environmental Studies, 195 Prospect Street, New Haven, CT 06511 USA. Telephone: (781) 696-4537; Email: kevin.lane@yale.edu Supplemental Material is available online (https://doi.org/10.1289...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Prognostic Value of Follow-up Hemodynamic Variables After Initial Management in Pulmonary Arterial Hypertension.
Conclusions -SVI and RAP were the hemodynamic variables independently associated with death or lung transplantation at first follow-up RHC after initial PAH treatment. These findings suggest that the SVI could be a more appropriate treatment target than the cardiac index in PAH. PMID: 29070502 [PubMed - as supplied by publisher]
Source: Circulation - October 25, 2017 Category: Cardiology Authors: Weatherald J, Boucly A, Chemla D, Savale L, Peng M, Jevnikar M, Jaïs X, Taniguchi Y, O'Connell C, Parent F, Sattler C, Hervé P, Simonneau G, Montani D, Humbert M, Adir Y, Sitbon O Tags: Circulation Source Type: research

Hospitalizations for cardiovascular disease after liver transplantation in the United States
Conclusions: CVD after liver transplant is evolving and responsible for growing rates of inpatient care. Transplant hospitals are associated with poor outcomes, even after risk adjustment for patient and hospital characteristics, which may be attributable to selective referral of certain patient phenotypes, but could also be related to differences in quality of care. Further study is warranted. This article is protected by copyright. All rights reserved.
Source: Liver Transplantation - March 15, 2018 Category: Transplant Surgery Authors: Narjeet S. Khurmi, Yu ‐Hui Chang, D. Eric Steidley, Andrew L. Singer, Winston R. Hewitt, Kunam S. Reddy, Adyr A. Moss, Amit K. Mathur Tags: Original Article Source Type: research

Cardiovascular Magnetic Resonance Imaging for Risk Assessment and Prediction of Clinical Worsening in Pulmonary Arterial Hypertension
To determine the clinically detectable changes of right ventricular (RV) volume and stroke volume (SV) that predicts clinical worsening in patients with pulmonary arterial hypertension (PAH).
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: C. G öransson, N. Vejlstrup, J. Carlsen Source Type: research

Invasive Hemodynamics and Rejection Rates in Patients with Cardiac Sarcoidosis After Heart Transplantation
Conclusions CS patients have similar post-transplant hemodynamics as non-CS patients, without evidence of RV dysfunction or pulmonary hypertension. No significant rejection nor recurrence of sarcoid in the allograft were observed in this cohort of patients with CS. Survival is similar between CS and non-CS patients. Heart transplant is a viable strategy in selected CS patients with excellent outcomes. Teaser Orthotopic heart transplant (OHT) is utilized for end-stage heart failure due to cardiac sarcoidosis (CS). There is a lack of data on long-term outcomes. We explored changes in hemodynamics, allograft rejection and sur...
Source: Canadian Journal of Cardiology - April 7, 2018 Category: Cardiology Source Type: research

Clinical and hemodynamic correlates of pulmonary arterial stiffness in incident, untreated patients with idiopathic pulmonary arterial hypertension.
CONCLUSIONS: In incident idiopathic PAH, PA stiffness was related to mPAP and heart rate, and this outperformed the potential influences of age and gender. Baseline PA stiffness did not independently predict outcome. The great dispersion of RC-time implied that PVR and PA stiffness were differently affected by the disease process. PMID: 29940163 [PubMed - as supplied by publisher]
Source: Chest - June 22, 2018 Category: Respiratory Medicine Authors: Chemla D, Weatherald J, Lau EMT, Savale L, Boucly A, Attal P, Jaïs X, Parent F, Girerd B, Simonneau G, Montani D, Humbert M, Sitbon O, Hervé P Tags: Chest Source Type: research

Unusual Techniques for Preserving Surgical and Oncologic Safety in Hepatectomy of Advanced Adrenal Malignancy with Vena Cava and Liver Invasion
We report herein three cases of major hepatectomy with IVC invasion and discuss several surgical tips.Patients and MethodsFrom March 2011 to February 2014, we retrospectively reviewed three cases of adrenal malignancy with liver and IVC invasion. Based on the severity of the malignant tumor, each case illustrates a different method to address surgical complications and maintain oncologic safety. Case 1: A 34-year-old woman was diagnosed with adrenocortical tumor during medical examination. Tumor invaded the right lobe of the liver and very close to the IVC. Fortunately, there was little thrombosis inside the IVC; we perfor...
Source: Annals of Surgical Oncology - September 6, 2018 Category: Cancer & Oncology Source Type: research

Haemodynamics and serial risk assessment in systemic sclerosis associated pulmonary arterial hypertension
The prognostic importance of follow-up haemodynamics and the validity of multidimensional risk assessment are not well established for systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH). We assessed incident SSc-PAH patients to determine the association between clinical and haemodynamic variables at baseline and first follow-up right heart catheterisation (RHC) with transplant-free survival. RHC variables included cardiac index, stroke volume index (SVI), pulmonary arterial compliance and pulmonary vascular resistance. Risk assessment was performed according to the number of low-risk criteria: functi...
Source: European Respiratory Journal - October 18, 2018 Category: Respiratory Medicine Authors: Weatherald, J., Boucly, A., Launay, D., Cottin, V., Prevot, G., Bourlier, D., Dauphin, C., Chaouat, A., Savale, L., Jaïs, X., Jevnikar, M., Traclet, J., De Groote, P., Simonneau, G., Hachulla, E., Mouthon, L., Montani, D., Humbert, M., Sitbon, O. Tags: Original Articles: Pulmonary hypertension Source Type: research

Complications of Solid Organ Transplantation
Despite improvements in overall graft function and patient survival rates after solid organ transplantation, complications can lead to significant morbidity and mortality. Cardiovascular complications include heart failure, arrhythmias leading to sudden death, hypertension, left ventricular hypertrophy, and allograft vasculopathy in heart transplantation. Neurologic complications include stroke, posterior reversible encephalopathy syndrome, infections, neuromuscular disease, seizure disorders, and neoplastic disease. Acute kidney injury occurs from immunosuppression with calcineurin inhibitors or as a result of graft failu...
Source: Critical Care Clinics - October 25, 2018 Category: Intensive Care Authors: Ayan Sen, Hannelisa Callisen, Stacy Libricz, Bhavesh Patel Source Type: research

Assessment of hypertension and its associated risk factors among medical students in Qassim University.
The objective of the study is to assess the prevalence of hypertension and its associated risk factors in medical students attending the College of Medicine in Qassim University, Qassim, Saudi Arabia. It is a cross-sectional study that was conducted during the year 2017 on medical students attending the College of Medicine at Qassim University. A total of 130 students were selected using multistage stratified random sampling. We collected data on sociodemographic information and risk factors using a self-administered questionnaire derived from the WHO STEPS instrument, and we measured the blood pressure and body mass index...
Source: Saudi Journal of Kidney Diseases and Transplantation - September 1, 2018 Category: Urology & Nephrology Authors: AlWabel AH, Almufadhi MA, Alayed FM, Aloraini AY, Alobaysi HM, Alalwi RM Tags: Saudi J Kidney Dis Transpl Source Type: research

Impact of Active Antihyperglycemic Components as herbal therapy for Preventive Health Care Management of Diabetes.
Abstract Diabetes is a metabolic hyperglycemic condition that progressively develops, effect small and large sensory fibers in affected population. It has various complications as hypertension, coronary artery disease, stroke, blindness, kidney disease as well as peripheral neuropathy. Sulfonylureas, thiazolidinediones, metformin, biguanidine, acarbose and insulin are commonly used drugs by diabetic patients, but these all have certain side effects. Even metformin, that is known as the miracle drug for diabetes has been found to be associated with side effects, as during treatment it involves complications with ey...
Source: Current Molecular Medicine - February 19, 2019 Category: Molecular Biology Authors: Kashyap H, Gupta S, Bist R Tags: Curr Mol Med Source Type: research

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