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Specialty: Biochemistry
Condition: Hemorrhagic Stroke

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Total 43 results found since Jan 2013.

Stroke injury, cognitive impairment and vascular dementia.
This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. PMID: 26806700 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - January 21, 2016 Category: Biochemistry Authors: Kalaria RN, Akinyemi R, Ihara M Tags: Biochim Biophys Acta Source Type: research

The Metal and Metalloprotein Profile of Human Plasma as Biomarkers for Stroke Diagnosis
Publication date: Available online 7 April 2017 Source:Journal of Trace Elements in Medicine and Biology Author(s): Keaton S. Nahan, Kyle B. Walsh, Opeolu Adeoye, Julio A. Landero-Figueroa Stroke, a major cause of disability and mortality, affects someone in the United States every 40seconds. Stroke biomarkers, including those that could be used as a blood test for diagnosis of stroke, have been particularly elusive. We performed a double blind study to identify human plasma biomarkers for the diagnosis of stroke, including acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH). We utilized a three-track approach ...
Source: Journal of Trace Elements in Medicine and Biology - April 10, 2017 Category: Biochemistry Source Type: research

Former antiplatelet drug administration and consequences of intravenous thrombolysis in acute ischemic stroke.
CONCLUSION: Based on the results of this study, patients with acute ischemic stroke and history of taking antiplatelet drugs have poor outcome following administration of standard dose of tPA. PMID: 31356199 [PubMed - as supplied by publisher]
Source: Human Antibodies - July 31, 2019 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Role of Brain Biomarker in Predicting Clinical Outcome in Hypertensive Cerebrovascular Ischemic Stroke
This study was undertaken to evaluate the role of serum neuron specific enolase (NSE) in prediction of disability and neurological worsening in hypertensive ischemic cerebrovascular stroke. 80 hypertensive ischemic stroke patients diagnosed by a neurologist as per WHO definition along with radiological findings suggestive of cerebrovascular stroke and differentiating from hemorrhagic stroke and 60 controls having essential hypertension coming to hospital because of regular checkup or headache but with no neurological disease were included in the study. Neurological disability was assessed by NIHSS at the time of admission ...
Source: Indian Journal of Clinical Biochemistry - April 1, 2018 Category: Biochemistry Source Type: research

Apolipoprotein E polymorphism and cerebral stroke.
Conclusions: The distribution of allelic frequencies of apolipoprotein E in the population of Constantine is similar to that of Southern Europe. Our results imply a role of the genotype of apolipoprotein E (ɛ4 allele) in the pathogenesis of stroke and are limited to the accidents of the ischemic type. The ɛ2 allele does not appear to be implied in occurred of this affection; however, large additional studies are necessary to confirm this result. PMID: 23396426 [PubMed - as supplied by publisher]
Source: Annales de Biologie Clinique - February 1, 2013 Category: Biochemistry Authors: Boumendjel S, Khodja D, Hamri A, Benlatreche C, Abadi N Tags: Ann Biol Clin (Paris) Source Type: research

Blood based protein biomarkers for stroke differentiation: A systematic review
Conclusion: Our systematic review does not recommend the use of any blood biomarker for clinical purposes yet based on the studies conducted till date.This article is protected by copyright. All rights reserved
Source: Proteomics. Clinical Applications - April 28, 2017 Category: Biochemistry Authors: Shubham Misra, Amit Kumar, Pradeep Kumar, Arun K Yadav, Dheeraj Mohania, Awadh K Pandit, Kameshwar Prasad, Deepti Vibha Tags: Review Source Type: research

Blood ‐based protein biomarkers for stroke differentiation: A systematic review
Computed tomography (CT) scan is the mainstay for diagnosis of stroke; but the facility of CT scan is not easily available. A blood‐based biomarker approach is required to distinguish ischemic stroke (IS) from hemorrhagic stroke (HS) in pre‐hospital settings.To conduct a systematic review of diagnostic utility of blood biomarkers for differential diagnosis of stroke.A comprehensive literature search was carried out till March 7, 2017 in PubMed, Cochrane, Medline, OVID, and Google Scholar databases. Methodological quality of each study was assessed using the modified Quality Assessment of Diagnostic Accuracy Studies que...
Source: Proteomics. Clinical Applications - May 29, 2017 Category: Biochemistry Authors: Shubham Misra, Amit Kumar, Pradeep Kumar, Arun K Yadav, Dheeraj Mohania, Awadh K Pandit, Kameshwar Prasad, Deepti Vibha Tags: Review Source Type: research

IM-12 activates the Wnt- β-catenin signaling pathway and attenuates rtPA-induced hemorrhagic transformation in rats after acute ischemic stroke.
In this study, we used IM-12, an inhibitor of glycogen synthase kinase 3β (GSK-3β), to evaluate the role of the Wnt-β-catenin signaling pathway in recombinant tPA (rtPA)-induced HT. Sprague-Dawley rats were subjected to a middle cerebral artery occlusion (MCAO) model of ischemic stroke, and then were either administered rtPA, rtPA combined with IM-12, or the vehicle at 4 h after stroke was induced. Our results indicate that rats subjected to HT had more severe neurological deficits, brain edema, and blood-brain barrier (BBB) breakdown, and had a greater infarction volume than the control group. Rats treated with IM-12 h...
Source: Biochemistry and Cell Biology - November 25, 2019 Category: Biochemistry Authors: Wang T, Duan YM, Fu Q, Liu T, Yu JC, Sui ZY, Huang L, Wen GQ Tags: Biochem Cell Biol Source Type: research

Involvement of microRNA214 and transcriptional regulation in reductions in mevalonate pyrophosphate decarboxylase mRNA levels in stroke-prone spontaneously hypertensive rat livers.
Abstract Hypocholesterolemia has been epidemiologically identified as one of the causes of stroke (cerebral hemorrhage). We previously reported that lower protein levels of mevalonate pyrophosphate decarboxylase (MPD), which is responsible for reducing serum cholesterol levels in stroke-prone spontaneously hypertensive rats (SHRSP), in the liver were caused by a reduction in mRNA levels. However, the mechanism responsible for reducing MPD expression levels in the SHRSP liver remains unclear. Thus, we compared microRNA (miR)-214 combined with the 3'-untranslated region of MPD mRNA and heterogeneous nuclear RNA (hnR...
Source: Bioscience, Biotechnology, and Biochemistry - July 9, 2015 Category: Biochemistry Authors: Michihara A, Ide N, Mizutani Y, Okamoto M, Uchida M, Matsuoka H, Akasaki K Tags: Biosci Biotechnol Biochem Source Type: research

Levels of tight junction protein CLDND1 are regulated by microRNA-124 in the cerebellum of stroke-prone spontaneously hypertensive rats.
Abstract The claudin family shows organ- and tissue-specific expression of individual members. Deficiency or aberrant expression of distinct claudins has been reported to be associated with severe pathophysiological consequences. Claudin domain-containing 1 (CLDND1), also known as claudin-25, shows homology to this family of proteins. Furthermore, serum CLDND1-derived peptide antibody levels are elevated in patients with cerebral infarction, as compared with healthy controls. We previously reported that, in the adult murine brain, CLDND1 is abundantly expressed in the cerebellum in common sites of intracerebral he...
Source: Biochemical and Biophysical Research communications - March 9, 2018 Category: Biochemistry Authors: Matsuoka H, Tamura A, Kinehara M, Shima A, Uda A, Tahara H, Michihara A Tags: Biochem Biophys Res Commun Source Type: research

Beneficial actions of prothymosin alpha-mimetic hexapeptide on central post-stroke pain, reduced social activity, learning-deficit and depression following cerebral ischemia in mice
Publication date: Available online 23 January 2020Source: PeptidesAuthor(s): Keita Sasaki, Sebok Kumar Halder, Hayato Matsunaga, Hiroshi UedaAbstractProthymosin alpha (ProTα)-mimetic hexapeptide (amino acid: NEVDQE, P6Q) inhibits cerebral or retinal ischemia-induced behavioral, electrophysiological and histological damage. P6Q also abolishes cerebral hemorrhage induced by ischemia with tissue plasminogen activator (tPA). In the present study we examined the beneficial effects of P6Q on other post-stroke prognostic psychology-related symptoms, which obstruct the motivation toward physical therapy. Intravenous (i.v.) admini...
Source: Peptides - January 24, 2020 Category: Biochemistry Source Type: research

Serum YKL-40 levels as a prognostic factor in patients with intracerebral hemorrhage.
CONCLUSIONS: YKL-40 is associated with inflammation and severity of intracerebral hemorrhage, and may independently predict long-term clinical outcomes of intracerebral hemorrhage. PMID: 25262987 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - September 25, 2014 Category: Biochemistry Authors: Jiang YX, Zhang GH, Wang ZM, Yang H Tags: Clin Biochem Source Type: research

Altered plasma levels of apixaban in major gastrointestinal tract surgery: a case report and review of the literature
We describe a case of suspected altered apixaban disposition in a patient with an upper gastrointestinal cancer resection treated with apixaban for non-valvular atrial fibrillation. Diagnosis of ischemic stroke for left hemiparesis was confirmed due to recent emergence of a hypodense area in the posterior capsular nucleus of ischemic reference in a context of binuclear capsular lacunar lesions. Thus, apixaban underexposure was suspected from anamnestic data and oral anticoagulation was switched to parenteral at the next scheduled dose for stroke recurrence. Before switching apixaban pharmacokinetic analysis was performed a...
Source: Clinical Biochemistry - July 14, 2023 Category: Biochemistry Authors: Giammarco Baiardi Alessia Cafaro Manuela Stella Michela Cameran Caviglia Maria Gabriella Poeta Giuliana Cangemi Francesca Mattioli Source Type: research

Altered plasma levels of apixaban in major gastrointestinal tract surgery: A case report and review of the literature
We describe a case of suspected altered apixaban disposition in a patient with an upper gastrointestinal cancer resection treated with apixaban for non-valvular atrial fibrillation. Diagnosis of ischemic stroke for left hemiparesis was confirmed due to recent emergence of a hypodense area in the posterior capsular nucleus of ischemic reference in a context of binuclear capsular lacunar lesions. Thus, apixaban underexposure was suspected from anamnestic data and oral anticoagulation was switched to parenteral at the next scheduled dose for stroke recurrence. Before switching apixaban pharmacokinetic analysis was performed a...
Source: Clinical Biochemistry - July 14, 2023 Category: Biochemistry Authors: Giammarco Baiardi Alessia Cafaro Manuela Stella Michela Cameran Caviglia Maria Gabriella Poeta Giuliana Cangemi Francesca Mattioli Source Type: research