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Total 86 results found since Jan 2013.

Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt
Conclusion We have shown that SCD subjects are much more likely than non-SCD subjects to have impaired cardiac, but intact peripheral responses to orthostatic stress induced by HUT. These abnormal responses are associated with low baseline cardiac parasympathetic activity, independent of hemoglobin level. The classification of autonomic phenotypes based on HUT response may have potential use for predicting disease severity, guiding and targeting treatments/interventions to alleviate the risk of adverse outcomes in SCD. Ethics Statement All experiments were conducted at Children’s Hospital Los Angeles (CHLA). The ...
Source: Frontiers in Physiology - April 10, 2019 Category: Physiology Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Long-Term Exposure to Transportation Noise in Relation to Development of Obesity —a Cohort Study
Conclusion: Our results link transportation noise exposure to development of obesity and suggest that combined exposure from different sources may be particularly harmful. https://doi.org/10.1289/EHP1910 Received: 17 March 2017 Revised: 5 October 2017 Accepted: 9 October 2017 Published: 20 November 2017 Address correspondence to A. Pyko, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Telephone: 46(0) 852487561. Email: Andrei.pyko@ki.se Supplemental Material is available online (https://doi.org/10.1289/EHP1910). The authors declare they have no actual or potential competing fina...
Source: EHP Research - November 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

Burden of disease from road traffic and railway noise – a quantification of healthy life years lost in Sweden
Conclusions Road traffic and railway noise contribute significantly to the burden of disease in Sweden each year. The total numbe r of DALY should, however, be interpreted with caution due to limitations in data quality.byEriksson C, Bodin T, Selander J. doi:10.5271/sjweh.3651
Source: Scandinavian Journal of Work, Environment and Health - June 9, 2017 Category: Occupational Health Tags: Original article Source Type: research

Burden of disease from road traffic and railway noise - a quantification of healthy life years lost in Sweden.
Conclusions Road traffic and railway noise contribute significantly to the burden of disease in Sweden each year. The total number of DALY should, however, be interpreted with caution due to limitations in data quality. PMID: 28599022 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Work, Environment and Health - June 9, 2017 Category: Occupational Health Authors: Eriksson C, Bodin T, Selander J Tags: Scand J Work Environ Health Source Type: research

Association of Long-Term Exposure to Transportation Noise and Traffic-Related Air Pollution with the Incidence of Diabetes: A Prospective Cohort Study
Conclusion: We found a positive association between residential transportation noise and diabetes, adding to the growing body of evidence that noise pollution exposure may be independently linked to metabolic health and should be considered when developing public health interventions. https://doi.org/10.1289/EHP1279 Received: 26 October 2016 Revised: 07 May 2017 Accepted: 09 May 2017 Published: 31 August 2017 Address correspondence to C. Clark, Ove Arup and Partners, Acoustics, 13 Fitzroy Street, London, W1T 4BQ, UK. Telephone: +44 207755 4702. Email: Charlotte.Clark@arup.com The authors declare they have no actual o...
Source: EHP Research - August 31, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Real-world retrospective cohort study ARCTIC shows burden of comorbidities in Swedish COPD versus non-COPD patients.
This study aimed to generate real-world evidence to assess the burden of comorbidities in COPD patients, to effectively manage these patients and optimize the associated healthcare resource allocation. ARCTIC is a large, real-world, retrospective cohort study conducted in Swedish COPD patients using electronic medical record data collected between 2000 and 2014. These patients were studied for prevalence of various comorbidities and for association of these comorbidities with exacerbations, mortality, and healthcare costs compared with an age-, sex-, and comorbidities-matched non-COPD reference population. A total of 17,47...
Source: Primary Care - September 10, 2018 Category: Primary Care Authors: Ställberg B, Janson C, Larsson K, Johansson G, Kostikas K, Gruenberger JB, Gutzwiller FS, Jorgensen L, Uhde M, Lisspers K Tags: NPJ Prim Care Respir Med Source Type: research

Non-cardiac comorbidities and mortality in patients with heart failure with reduced vs. preserved ejection fraction: a study using the Swedish Heart Failure Registry
ConclusionsNon-cardiac comorbidities contribute significantly but differently to mortality, both in HFrEF and HFpEF. No significant variation was found in the impact over the 12-year study period. These results emphasize the importance of including the management of comorbidities as a part of a standardized heart failure care in both HF phenotypes.
Source: Clinical Research in Cardiology - February 20, 2019 Category: Cardiology Source Type: research

This way for brain tingles: ASMR gets a shiver-inducing exhibition
From cucumber-crunchers to cranial exams, YouTube is full of ASMRtists provoking the strangely pleasurable autonomous sensory meridian response. Now they ’ve got their own euphoric museum showSome whisper gently into the microphone, while tapping their nails along the spine of a book. Others take a bar of soap andslice it methodically into tiny cubes, letting the pieces clatter into a plastic tray. There are those who dress up as doctors and pretend toperform a cranial nerve exam, and the ones who eat food as noisily as they can, recording every crunch and slurp in 3D stereo sound.To an outsider, the world of ASMR videos...
Source: Guardian Unlimited Science - March 31, 2020 Category: Science Authors: Oliver Wainwright Tags: Art Psychology Health & wellbeing Social trends Art and design Culture Technology Exhibitions Museums Installation Video art Sweden Painting Anxiety Alternative medicine Animal behaviour Science Life and style World Source Type: news

Effect of obstructive sleep apnoea on cardiovascular outcomes in patients with acute coronary syndrome: a secondary analysis of the RICCADSA trial
Conclusions: OSA is an independent risk factor for MACCE in revascularized patients with ACS.Clinical trial registration: NCT00519597Funding: The Swedish Research Council, ResMed Foundation.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Peker, Y., Thunström, E., Glantz, H., Eulenburg, C. Tags: Sleep and control of breathing Source Type: research

Napping Might Be Bad for the Heart, Study Finds
Napping, as well as sleeping too much or too little or having poor sleep patterns, appears to increase the risk for cardiovascular disease in older adults, new research shows. The study, published Tuesday in the Journal of the American Heart Association, adds to a growing body of evidence supporting sleep’s importance to good health. The American Heart Association recently added sleep duration to its checklist of health and lifestyle factors for cardiovascular health, known as Life’s Essential 8. It says adults should average seven to nine hours of sleep a night. “Good sleep behavior is essential to prese...
Source: TIME: Health - July 27, 2022 Category: Consumer Health News Authors: Laura Williamson, American Heart Association News/AP Tags: Uncategorized healthscienceclimate Research wire Source Type: news

Attention-deficit/hyperactivity disorder as a risk factor for cardiovascular diseases: a nationwide population-based cohort study
World Psychiatry. 2022 Oct;21(3):452-459. doi: 10.1002/wps.21020.ABSTRACTAccumulating evidence suggests a higher risk for cardiovascular diseases among individuals with mental disorders, but very little is known about the risk for overall and specific groups of cardiovascular diseases in people with attention-deficit/hyperactivity disorder (ADHD). To fill this knowledge gap, we investigated the prospective associations between ADHD and a wide range of cardiovascular diseases in adults. In a nationwide population-based cohort study, we identified 5,389,519 adults born between 1941 and 1983, without pre-existing cardiovascul...
Source: World Psychiatry - September 8, 2022 Category: Psychiatry Authors: Lin Li Zheng Chang Jiangwei Sun Miguel Garcia-Argibay Ebba Du Rietz Maja Dobrosavljevic Isabell Brikell Tomas Jernberg Marco Solmi Samuele Cortese Henrik Larsson Source Type: research