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Specialty: Neurology
Condition: Epilepsy
Education: Study

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Total 662 results found since Jan 2013.

Acute symptomatic seizures and epilepsy after mechanical thrombectomy. A prospective long-term follow-up study.
Poststroke seizures are a common complication of stroke. Overall, 2.3-10% of patients with stroke will develop seizures, most of them during the acute phase [1,3], currently associated with increased acute morbidity and mortality [3].
Source: Seizure: European Journal of Epilepsy - April 13, 2021 Category: Neurology Authors: M Alemany, A Nu ñez, M Falip, B Lara, A Paipa, H Quesada, P Mora, MA De Miquel, R Barranco, J Pedro, Portela P Cardona Source Type: research

Cardiovascular disease risk, awareness, and treatment in people with epilepsy
CONCLUSIONS: Participants with epilepsy had increased ASCVD risk, despite similar or better awareness, treatment, and control of individual risk factors such as diabetes and hypertension. Our results suggest that epilepsy is associated with numerous health behaviors leading to cardiovascular disease, though the causal pathway is complex as these variables (income, depression, diet, exercise, smoking) generally served as confounders rather than mediators.PMID:33690068 | DOI:10.1016/j.yebeh.2021.107878
Source: Epilepsy and Behaviour - March 10, 2021 Category: Neurology Authors: Samuel W Terman Carole E Aubert Chloe E Hill Jeremy Skvarce James F Burke Scott Mintzer Source Type: research

Seizures and epilepsy after intracerebral hemorrhage: an update
AbstractSeizures are common after intracerebral hemorrhage, occurring in 6 –15% of the patients, mostly in the first 72 h. Their incidence reaches 30% when subclinical or non-convulsive seizures are diagnosed by continuous electroencephalogram. Several risk factors for seizures have been described including cortical location of intracerebral hemorrhage, presence of intr aventricular hemorrhage, total hemorrhage volume, and history of alcohol abuse. Seizures after intracerebral hemorrhage may theoretically be harmful as they can lead to sudden blood pressure fluctuations, increased intracranial pressure, and neuronal inj...
Source: Journal of Neurology - February 10, 2021 Category: Neurology Source Type: research

Association of Epileptiform Abnormality on Electroencephalography with Development of Epilepsy After Acute Brain Injury
ConclusionsEAs on cEEG in patients with ABI are associated with a greater than three-fold increased risk of new-onset epilepsy. cEEG findings in ABI may therefore be a useful risk stratification tool for assessing long-term risk of seizures and serve as a biomarker for new-onset epilepsy.
Source: Neurocritical Care - January 20, 2021 Category: Neurology Source Type: research

TRPM7 Mediates Neuronal Cell Death Upstream of Calcium/Calmodulin-Dependent Protein Kinase II and Calcineurin Mechanism in Neonatal Hypoxic-Ischemic Brain Injury
In this study, we employed a mouse model of hypoxic-ischemic brain cell death which mimics the pathophysiology of hypoxic-ischemic encephalopathy (HIE). HIE is a major public health issue and an important cause of neonatal deaths worldwide; however, the available treatments for HIE remain limited. Its survivors face life-long neurological challenges including mental retardation, cerebral palsy, epilepsy and seizure disorders, motor impairments, and visual and auditory impairments. Through a proteomic analysis, we identified calcium/calmodulin-dependent protein kinase II (CaMKII) and phosphatase calcineurin as potential med...
Source: Translational Stroke Research - January 12, 2021 Category: Neurology Source Type: research

Antihistamines as a common cause of new-onset seizures: a single-center observational study
ConclusionIn our population, antihistamine accounted for the highest proportion of drug-induced seizures. Considering that antihistamines are widely used as over-the-counter drugs around the world, they should be considered a possible cause of new-onset seizures.
Source: Neurological Sciences - January 12, 2021 Category: Neurology Source Type: research

Prevalence of Mimics and Severe Comorbidity in Patients with Clinically Suspected Transient Global Amnesia
Conclusion: As approximately every tenth patient with suspected TGA either had an alternative diagnosis or a severe comorbidity, which had not been obvious at the time of admission, we consider in-patient treatment of all suspected TGA cases as appropriate, preferably in the setting of a stroke unit, as ischemic stroke was the by far most important diagnosis mimicking TGA.Cerebrovasc Dis
Source: Cerebrovascular Diseases - January 7, 2021 Category: Neurology Source Type: research

Telemedicine in neurology: current evidence
Conclusion: Current evidence supports that teleneurology can be a tool to increase care for patients suffering from neurological diseases.RESUMO Introdu ção: A telemedicina surge pela primeira vez na neurologia como uma ferramenta para facilitar o acesso ao tratamento do acidente vascular cerebral (AVC) Agudo. Mais recentemente, inúmeras evidências têm surgido acerca da eficácia e da segurança do uso da telemedicina em várias outras áreas d a neurologia. Com o advento da pandemia de COVID-19 e a necessidade de isolamento social, as autoridades brasileiras flexibilizaram a regulamentação da telemedicina, permitin...
Source: Arquivos de Neuro-Psiquiatria - December 14, 2020 Category: Neurology Source Type: research

Late-onset epilepsy predicts stroke: Systematic review and meta-analysis.
Abstract OBJECTIVE: Late-onset epilepsy (LOE) is closely associated with cerebrovascular disease, acting as both a marker of cerebrovascular disease (CVD) and occurring as a direct consequence. Despite this, our understanding of LOE as a cerebrovascular phenomenon is in its infancy. LOE also appears to be a harbinger of dementia. METHODS: A systematic review was performed to identify publications relating to LOE and identified observational studies, clinical studies, and radiological studies. RESULTS: A meta-analysis of observational studies demonstrated that patients presenting with LOE experience an in...
Source: Epilepsy and Behaviour - December 14, 2020 Category: Neurology Authors: Wall J, Knight J, Emsley HCA Tags: Epilepsy Behav Source Type: research

Neuroprotective and Neurorestorative Effects of Epo and VEGF: Perspectives for New Therapeutic Approaches to Neurological Diseases.
CONCLUSION: Because the Epo and VEGF signalling pathways are connected in several ways, we conclude that more experimental studies, primarily studies designed to thoroughly assess the functional interactions between Epo and VEGF in the brain under both physiological and pathophysiological conditions, are needed. PMID: 31942853 [PubMed - indexed for MEDLINE]
Source: Epilepsy Curr - November 20, 2020 Category: Neurology Authors: Ureña-Guerrero ME, Castañeda-Cabral JL, Rivera-Cervantes MC, Macias-Velez RJ, Jarero-Basulto JJ, Gudiño-Cabrera G, Beas-Zárate C Tags: Curr Pharm Des Source Type: research

The Potential Clinical Properties of Magnesium.
Abstract A significant percentage of costs in pharmaceutical markets is devoted to supplements, due to the confidence of consumers on the beneficial effects of these products. Magnesium is one of the supplements with enduring and increasing popularity. According to what is reported online this metal ion can cure, or prevent, almost all kind of diseases. This review aims at illustrating a series of scientifically demonstrated cases in which magnesium was used in clinical practice. Except for its ordinary use as antacid and laxative, other ascertained uses, reported in scientific literature, consist in helping to tr...
Source: Epilepsy Curr - November 16, 2020 Category: Neurology Authors: Crisponi G, Nurchi VM, Cappai R, Zoroddu MA, Gerosa C, Piras M, Faa G, Fanni D Tags: Curr Med Chem Source Type: research

PSA mimetic 5-nonyloxytryptamine protects cerebellar neurons against glutamate induced excitotoxicity: An in vitro perspective.
Abstract PSA-NCAM is a molecule of therapeutic interest for its key role in promoting neuritogenesis and synaptic plasticity. The current study was aimed to investigate the neuroregenerative potential of 5-nonyloxytryptamine (5-NOT) as PSA mimetic compound against glutamate induced excitotoxicity. 2D and 3D cultures of cerebellar neurons challenged with glutamate were used to ascertain the effect of 5-NOT on neurite outgrowth, migration and expression of neuronal plasticity markers. Glutamate excitotoxicity is one of the major underlying pathological factor responsible for neurodegeneration in various neurological...
Source: Neurotoxicology - November 13, 2020 Category: Neurology Authors: Kalotra S, Kaur G Tags: Neurotoxicology Source Type: research

Risk Factors of Post-Stroke Epilepsy in Children; Experience from a Tertiary Center and a Brief Review of the Literature
Arterial ischemic stroke (AII) is a significant cause of acute seizures, and survivors frequently develop post-stroke epilepsy (PSE).1 The frequency of PSE has been widely studied in adults. Post-stroke seizures have been reported in 5 –20% of elderly individuals, whereas the development of epilepsy is rare and ranges from 2% to 15%.2–4 Few studies have investigated risk factors for PSE in children. Due to variations in study population characteristics, sample size, and age range, PSE frequencies vary in children.
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2020 Category: Neurology Authors: İpek Polat, Uluç Yiş, Müge Ayanoğlu, Derya Okur, Pınar Edem, Cem Paketçi, Erhan Bayram, Semra Hız Kurul Source Type: research

One-Year Analysis of Risk Factors Associated With Cognitive Impairment in Newly Diagnosed Epilepsy in Adults
This study aimed to identify factors associated with CI in adult patients with newly diagnosed epilepsy. Additionally, we sought to determine whether any particular cognitive function is impaired predominantly by anti-seizure medications or by other factors. We enrolled 229 patients with newly diagnosed epilepsy and 191 participants were followed up for 1 y. We used the Montreal Cognitive Assessment as a tool to quantify CI. The sub-item scores were also collected to assess whether any aspects of CI are predominantly affected by anti-seizure medication treatment. Subjective memory decline due to anti-seizure medications wa...
Source: Frontiers in Neurology - November 6, 2020 Category: Neurology Source Type: research