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Contact Allergy in Atopic Patients: What We Suspected and What We Know
Opinion Statement Contact allergy in children was previously considered to be uncommon. However, data from the last decades have shown an increase in its prevalence, which is thought to result from more frequent exposure to allergens at a younger age, new trends in body piercing, use of cosmetic and pharmaceutical products, and participation in sports and hobbies. Factors that may influence the onset of sensitization in children are atopic dermatitis, skin barrier defects, and intense or repetitive contact with allergens. Although there are many similarities between adult and children with contact allergy, the pat...
Source: Current Treatment Options in Allergy - May 29, 2015 Category: Allergy & Immunology Source Type: research

Non-IgE-Related Diagnostic Methods (LST, Patch Test).
Authors: Matsumoto K Abstract Although most food allergy patients have immediate-type reactions, some have delayed-type reactions. Unlike for the detection of food-specific IgE antibody in immediate-type (IgE-mediated) food allergies, only a few tests are currently available to aid in the diagnosis of delayed-type (non-IgE-mediated) food allergies. This chapter summarizes our current understanding of one in vitro test and one in vivo test for non-IgE-mediated food allergies: the lymphocyte stimulation test (LST) and the atopy patch test (APT). Although the LST is not yet standardized, a food protein-specific LST mi...
Source: Chemical Immunology and Allergy - May 31, 2015 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Calculating the effect of population-level implementation of the Learning Early About Peanut Allergy (LEAP) protocol to prevent peanut allergy
The Learning Early About Peanut Allergy (LEAP) study demonstrated a 70% to 86% relative reduction in the incidence of peanut allergy (PA) in high-risk infants (with severe atopic dermatitis [AD] or egg allergy) if peanut was introduced between 4 and 11 months of age.1 Using data about AD and egg sensitization collected from BASELINE, Ireland's first unselected prospective birth cohort study,2-5 we calculated the effect of implementing the LEAP protocol in our population.
Source: Journal of Allergy and Clinical Immunology - February 10, 2016 Category: Allergy & Immunology Authors: Cathal O'Connor, Maeve Kelleher, Jonathan O'B Hourihane Tags: Letter to the Editor Source Type: research

Timing of allergen exposure and the development of food allergy: treating before the horse is out of the barn
Purpose of review: Until recently, nutritional guidelines did not support early introduction of allergenic foods into the diet of high-risk infants. Following recent studies, this approach is beginning to change, at least for peanuts. This review will examine the change in nutritional guidelines and the scientific data that led to these changes. Recent finding: In a recent prospective controlled study, regular consumption of peanut protein in infants from 4–11 months of age with atopic dermatitis or egg allergy, was associated with lower prevalence of peanut allergy (1.9%) at 60 months of age compared with peanut avoida...
Source: Current Opinion in Allergy and Clinical Immunology - February 26, 2016 Category: Allergy & Immunology Tags: PEDIATRIC ASTHMA AND DEVELOPMENT OF ATOPY: Edited by Leonard B. Bacharier and Stanley Szefler Source Type: research

Food allergy is associated with colonization in children with atopic dermatitis
Atopic dermatitis (AD) commonly precedes the development of food allergy.1 The reasons for this close association are not well characterized. Recent studies in patients with AD found that peanut allergy was associated with filaggrin (FLG) mutations.1,2 This finding suggests that skin barrier dysfunction contributes to the development of food allergy by promoting epicutaneous allergen absorption and sensitization. However, FLG mutations are absent in most patients with AD,1 and a recent study conducted in the United States did not demonstrate the close relationship between peanut allergy and FLG mutations in children with AD.
Source: Journal of Allergy and Clinical Immunology - March 6, 2016 Category: Allergy & Immunology Authors: Andrea L. Jones, Douglas Curran-Everett, Donald Y.M. Leung Tags: Letter to the Editor Source Type: research

Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis
Atopic dermatitis (AD) commonly precedes the development of food allergy.1 The reasons for this close association are not well characterized. Recent studies in patients with AD found that peanut allergy was associated with filaggrin (FLG) mutations.1,2 This finding suggests that skin barrier dysfunction contributes to the development of food allergy by promoting epicutaneous allergen absorption and sensitization. However, FLG mutations are absent in most patients with AD,1 and a recent study conducted in the United States did not demonstrate the close relationship between peanut allergy and FLG mutations in children with AD.
Source: Journal of Allergy and Clinical Immunology - March 6, 2016 Category: Allergy & Immunology Authors: Andrea L. Jones, Douglas Curran-Everett, Donald Y.M. Leung Tags: Letter to the Editor Source Type: research

Precision medicine in patients with allergic diseases: Airway diseases and atopic dermatitis—PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology
In this consensus document we summarize the current knowledge on major asthma, rhinitis, and atopic dermatitis endotypes under the auspices of the PRACTALL collaboration platform. PRACTALL is an initiative of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology aiming to harmonize the European and American approaches to best allergy practice and science. Precision medicine is of broad relevance for the management of asthma, rhinitis, and atopic dermatitis in the context of a better selection of treatment responders, risk prediction, and design of disease-modifying strategies.
Source: Journal of Allergy and Clinical Immunology - April 30, 2016 Category: Allergy & Immunology Authors: Antonella Muraro, Robert F. Lemanske, Peter W. Hellings, Cezmi A. Akdis, Thomas Bieber, Thomas B. Casale, Marek Jutel, Peck Y. Ong, Lars K. Poulsen, Peter Schmid-Grendelmeier, Hans-Uwe Simon, Sven F. Seys, Ioana Agache Tags: Reviews and feature article Source Type: research

Allergic contact dermatitis in preservatives: current standing and future options
Purpose of review: Preservatives are well known skin sensitizers and represent one of the main causes of contact allergy. The purpose of this article is to review the current state of contact sensitization induced by preservatives and point future alternatives for products’ preservation. Recent findings: Isothiazolinones currently are the most common preservatives responsible of contact allergy in Europe and in the United States, and although some regulatory interventions have been taken place, the current contact allergy outbreak is not yet under control. Despite the ban of methyldibromo glutaronitrile from cosmetics i...
Source: Current Opinion in Allergy and Clinical Immunology - June 29, 2017 Category: Allergy & Immunology Tags: SKIN ALLERGY: Edited by Thomas Werfel and Torsten Zuberbier Source Type: research

A Patch Testing Initiative for the Investigation of Allergic Contact Dermatitis in a UK Allergy Practice: A Retrospective Study
ConclusionACD was detected in almost 50% of assessed patients and we highlight the importance of assessing relevance. Hydroperoxides of limonene and linalool are notable additions to the prevalence data. Patch testing should be incorporated into more allergy practices, although availability of training is a limiting factor.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 7, 2018 Category: Allergy & Immunology Source Type: research

Role of Superantigens in Allergic Inflammation: Their Relationship to Allergic Rhinitis, Chronic Rhinosinusitis, Asthma, and Atopic Dermatitis.
Conclusion Just as SAgs are known to feature in many allergic conditions, they play their part in AR, chronic rhinosinusitis, asthma, and AD. Further research is required before the relationship between SAgs and allergy can be adequately explained. PMID: 30253652 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - September 25, 2018 Category: ENT & OMF Authors: Muluk NB, Altın F, Cingi C Tags: Am J Rhinol Allergy Source Type: research

Recent Advances in Clinical Allergy and Immunology
Allergic diseases are of great concern because of their high prevalence, which is still rising in several regions, their impact on patients ’ physical and psychological health, the huge burden they place on patients’ quality of life, as well as the socioeconomic consequences that they cause. Recent research has provided new data on both genetic and environmental risk factors of atopic/allergic diseases. The application of new techno logies such as “omics” has allowed a better understanding of the pathogenesis and has helped with the identification of therapeutic targets. Immense progress has been made in developing...
Source: International Archives of Allergy and Immunology - November 7, 2018 Category: Allergy & Immunology Source Type: research

Cutaneous allergy: control that itch-scratch cycle!
Recent publications in The Annals of Allergy, Asthma and Immunology have documented the pain and suffering associated with cutaneous allergy.1,2 In the current issue of The Annals, Jonathan Silverberg reviews a number of comorbid health problems associated with atopic dermatitis (AD). Of greatest interest to allergists, AD predisposes to a higher risk of food allergy, eosinophilic esophagitis, and respiratory allergy.3 The systemic effects of AD are also manifested by a higher risk for infectious and cardiovascular risk.
Source: Annals of Allergy, Asthma and Immunology - July 31, 2019 Category: Allergy & Immunology Authors: Donald Y.M. Leung Tags: Editorial Source Type: research

Clinical Manifestations and Risk Factors of Anaphylaxis in Pollen-Food Allergy Syndrome.
CONCLUSION: The most common culprit foods causing anaphylaxis in PFAS were peanut and apple. The presence of atopic dermatitis; sensitization to hazel, timothy, or ragweed; and a greater number of culprit foods were risk factors for anaphylaxis in PFAS. PMID: 31538431 [PubMed - in process]
Source: Yonsei Medical Journal - September 22, 2019 Category: Universities & Medical Training Authors: Kim M, Ahn Y, Yoo Y, Kim DK, Yang HJ, Park HS, Lee HJ, Kim MA, Jeong YY, Kim BS, Bae WY, Jang AS, Park Y, Koh YI, Lee J, Lim DH, Kim JH, Lee SM, Kim YM, Jun YJ, Kim HY, Kim Y, Choi JH, Work Group for Rhinitis, the Korean Academy of Asthma, Allergy and Cli Tags: Yonsei Med J Source Type: research

The Journal of Allergy and Clinical Immunology: In Practice 2019 Highlights
This article provides highlights of the clinically impactful original studies and reviews published in The Journal of Allergy and Clinical Immunology: In Practice in 2019 on the subjects of anaphylaxis, asthma, dermatitis, drug allergy, food allergy, immunodeficiency, immunotherapy, rhinitis/sinusitis, and urticaria/angioedema/mast cell disorders. Within each topic, practical aspects of diagnosis and management are emphasized. Treatments discussed include lifestyle modifications, allergen avoidance therapy, positive and negative effects of pharmacologic therapy, and various forms of immunologic and desensitization manageme...
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 22, 2020 Category: Allergy & Immunology Source Type: research

Tackling Food Allergy in Infancy
This article focuses on identification, diagnosis, management, and prevention of food allergy in the infant population.
Source: Immunology and Allergy Clinics of North America - March 24, 2021 Category: Allergy & Immunology Authors: Ashley Lynn Devonshire, Adora A. Lin Source Type: research