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Total 865 results found since Jan 2013.

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

Diet therapy along with Nutrition Education can Improve Renal Function in People with Stages 3-4 chronic kidney disease who do not have diabetes. (A randomized controlled trial)
Br J Nutr. 2022 Jul 7:1-36. doi: 10.1017/S0007114522002094. Online ahead of print.ABSTRACTThe current trial investigates the effect of renal diet therapy and nutritional education on the estimated Glomerular Filtration Rate (eGFR), blood pressure, and depression among patients with CKD. A total of 120 CKD patients (stages 3-4) (15<eGFR<60) were randomized into an intensive nutrition intervention group (individualized renal diet therapy plus nutrition counseling: 0.75 g protein/kg/day and 30-35 kcal/kg/day with sodium restriction) and a control group (routine and standard care) for 24 weeks. The primary outcome was th...
Source: The British Journal of Nutrition - July 7, 2022 Category: Nutrition Authors: Maryam Hamidianshirazi Maryam Shafiee Maryam Ekramzadeh Mahsa Torabi Jahromi Farzad Nikaein Source Type: research

How A Nurse With a Hole in Her Skull Changed The Medical History of Migraines
The following is adapted from an excerpt from social and medical historian Katherine Foxhall’s new book, Migraine: A History, published by Johns Hopkins University Press, and out June 18, 2019. In 1936, Alfred Goltman, a physician from Tennessee, reported on one of his cases in the prominent medical journal Allergy. The patient was a 26-year-old woman with a history of headaches, nausea, and vomiting since childhood. Goltman believed the observations he had made on this patient helped reveal the pathological physiology of migraine. He had first met the woman, a registered nurse, in 1931. He recorded that for as lon...
Source: TIME: Health - June 18, 2019 Category: Consumer Health News Authors: Katherine Foxhall Tags: Uncategorized Headache History Migraine Source Type: news

Short-term medical treatment of hypercalcaemia in primary hyperparathyroidism predicts symptomatic response after parathyroidectomy.
CONCLUSION: The method described in this study may be used to aid surgical decision-making for patients with primary hyperparathyroidism and non-disease-specific symptoms by predicting the effects of normalization of hypercalcaemia. PMID: 31595982 [PubMed - as supplied by publisher]
Source: The British Journal of Surgery - October 8, 2019 Category: Surgery Authors: Koman A, Ohlsson S, Bränström R, Pernow Y, Bränström R, Nilsson IL Tags: Br J Surg Source Type: research

Medical News Today: What happens when calcium levels are low?
We describe these issues in detail and explore symptoms and when to seek treatment. Learn more about calcium deficiency disease here.
Source: Health News from Medical News Today - May 21, 2018 Category: Consumer Health News Tags: Osteoporosis Source Type: news

Nine Antihypertensive Drugs Associated With Reduced Risk for Depression Nine Antihypertensive Drugs Associated With Reduced Risk for Depression
A 2005-2015 study found reduced risk for depression in angiotensin agents (ACE inhibitors or angiotensin II receptor blockers), calcium antagonists, beta-blockers, and diuretics.Medscape Medical News
Source: Medscape Medical News Headlines - August 26, 2020 Category: Consumer Health News Tags: Cardiology News Source Type: news

Unlucky numbers: Fighting murder convictions that rest on shoddy stats
LEIDEN, THE NETHERLANDS— When a Dutch nurse named Lucia de Berk stood trial for serial murder in 2003, statistician Richard Gill was aware of the case. But he saw no reason to stick his nose into it. De Berk was a pediatric nurse at Juliana Children’s Hospital in The Hague. In 2001, after a baby died while she was on duty, a colleague told superiors that De Berk had been present at a suspiciously high number of deaths and resuscitations. Hospital staff immediately informed the police. When investigators reexamined records from De Berk’s shifts, they found 10 suspicious incidents. Three other hospitals where D...
Source: Science of Aging Knowledge Environment - January 19, 2023 Category: Geriatrics Source Type: research

Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years
Conclusions: The observed associations between BPA, MnBP, and behavior in boys are consistent with previous findings. Further health impact assessment studies based on dose–response functions corrected for exposure misclassification are required to quantify the public health burden possibly entailed by such associations. https://doi.org/10.1289/EHP1314 Received: 02 November 2016 Revised: 23 May 2017 Accepted: 19 June 2017 Published: 15 September 2017 Address correspondence to C. Philippat, Institut for Advanced Biosciences, Site Santé – Allée des Alpes, 38700 La Tronche, France. Phone: +33 4 76 54 94 66, Email:...
Source: EHP Research - September 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Galvanic Skin Response (GSR)/Electrodermal/Skin Conductance Biofeedback on Epilepsy: A Systematic Review and Meta-Analysis
Conclusion Despite the above limitations, this systematic review supports a view that modulation of sympathetic activity using GSR biofeedback represents a promising new therapeutic tool for management of seizures in patients with epilepsy. For future clinical trials, important elements to be considered include size of patient population, seizure type, double-blinding, inclusion of an appropriate control group, and robust randomization methods. Ethics Statement We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidel...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

The treatment of depression — searching for new ideas
Depression is a severe mental health problem that affects people regardless of social status or education, is associated with changes in mood and behavior, and can result in a suicide attempt. Therapy of depressive disorders is based mainly on drugs discovered in the 1960s and early 1970s. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are frontline pharmacological strategies for the medical treatment of depression. In addition, approved by FDA in 2019, esketamine [as nasal spray; N-methyl-D-aspartate (NMDA) receptors antagonist with additional effects on α-Amino-3...
Source: Frontiers in Pharmacology - October 7, 2022 Category: Drugs & Pharmacology Source Type: research

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

The RstAB System Impacts Virulence, Motility, Cell Morphology, Penicillin Tolerance and Production of Type II Secretion System-Dependent Factors in the Fish and Human Pathogen Photobacterium damselae subsp. damselae
This study establishes RstAB as a major regulator of virulence and diverse cellular functions in P. damselae subsp. damselae. Introduction Two-component signal transduction systems enable bacteria to sense environmental stimuli and transfer this information across the cytoplasmic membrane to the cytoplasm (Stock et al., 2000). Such systems consist of a membrane-embedded protein kinase which acts as a sensory component, and its cognate response regulator, a cytoplasmic transcriptional factor. When the sensory component of the pair is stimulated by a specific signal, it autophosphorylates a histidine residue and then...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research