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Total 407 results found since Jan 2013.

Long-term outcomes of stand-alone Maze IV for persistent/long-standing persistent atrial fibrillation
ConclusionsThis study confirmed the safety and efficacy at long-term (7 years) of the stand-alone Maze IV surgical procedure for persistent/long-standing persistent AF. Indeed, more than 70% of the pts were in SR off class I/III AADs and off oral anticoagulation.Graphical abstract
Source: The Annals of Thoracic Surgery - July 18, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Long-term outcomes of stand-alone Maze IV for persistent/long-standing persistent atrial fibrillation.
CONCLUSIONS: This study confirmed the safety and efficacy at long-term (7 years) of the stand-alone Maze IV surgical procedure for persistent/long-standing persistent AF. Indeed, more than 70% of the pts were in SR off class I/III AADs and off oral anticoagulation. PMID: 31325420 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - July 16, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Lapenna E, De Bonis M, Giambuzzi I, Del Forno B, Ruggeri S, Cireddu M, Gulletta S, Castiglioni A, Alfieri O, Della Bella P, Benussi S Tags: Ann Thorac Surg Source Type: research

Mental Ills May Put Veterans at Higher Odds for Heart Trouble
TUESDAY, Sept. 24, 2019 -- Veterans who suffer from depression, anxiety, psychosis or bipolar disorder are more likely to suffer a heart attack, stroke or die from heart disease, a new study finds. Those who have most severe mental health problems,...
Source: Drugs.com - Daily MedNews - September 24, 2019 Category: General Medicine Source Type: news

The Dynamics of Microglial Polarization Reveal the Resident Neuroinflammatory Responses After Subarachnoid Hemorrhage
In this study, we investigated the dynamics of microglial reaction in an endovascular perforated SAH model. By using the Cx3cr1GFP/GFP Ccr2RFP/RFP transgenic mice, we found that the reactive immune cells were largely from resident microglia pool rather than infiltrating macrophages. Immunostaining and real-time PCR were employed to analyze the temporal microglial polarization and the resulting inflammatory responses. Our results showed that microglia accumulated immediately after SAH with a centrifugal spreading through the Cortex Adjacent to the Perforated Site (CAPS) to the remote motor cortex. Microglia polarized dynami...
Source: Translational Stroke Research - October 17, 2019 Category: Neurology Source Type: research

Long-term Outcomes of Stand-Alone Maze IV for Persistent or Long-standing Persistent Atrial Fibrillation
ConclusionsThis study confirmed the safety and efficacy in the long term (7 years) of the stand-alone Cox-Maze IV surgical procedure for persistent or long-standing persistent AF. Indeed, more than 70% of the patients were in sinus rhythm off class I or III AADs and off oral anticoagulation.Visual Abstract
Source: The Annals of Thoracic Surgery - December 14, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

The Prevalence and Factors Associated with Antiepileptic Drug Use in US Nursing Home Residents
ConclusionsAED use was common in nursing homes, with gabapentin most commonly used (presumably for pain). That multiple comorbidities were associated with AED use underscores the need for future studies to investigate the safety and effectiveness of AED use in nursing home residents.
Source: Drugs and Aging - December 15, 2019 Category: Geriatrics Source Type: research

Dual-Antithrombotic Therapy With DOACs After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Atrial Fibrillation: A Meta-analysis of Randomized Controlled Trials
ConclusionsIn patients with AF and recent ACS or PCI, the use of dual-antithrombotic therapy with DOACs was associated with less major bleeding and less major bleeding or clinically relevant nonmajor bleeding compared with triple therapy. The use of dual therapy also showed nonsignificantly higher composite of death and ischemic events but no difference in mortality.RésuméContexteIl est difficile de choisir un traitement antithrombotique en cas de fibrillation auriculaire (FA) chez les patients ayant subi un syndrome coronarien aigu (SCA) ou une intervention coronarienne percutanée (ICP). Nous avons comparé les résult...
Source: Canadian Journal of Cardiology - December 24, 2019 Category: Cardiology Source Type: research

Lithium treatment mitigates white matter injury after intracerebral hemorrhage through brain-derived neurotrophic factor signalling in mice
Intracerebral hemorrhage (ICH), a subtype of stroke with high morbidity and mortality, occurs mainly in the basal ganglia and causes white matter injury (WMI), resulting in severe motor dysfunction and poor prognosis in patients. The preservation of the white matter around the hematoma is crucial for motor function recovery, but there is currently no effective treatment for WMI following ICH. Lithium has been widely used for the treatment of bipolar disorder for decades. Although the protective effects of lithium on neurodegenerative diseases and cerebral trauma have been studied in recent years, whether it can be used to ...
Source: Translational Research - December 26, 2019 Category: Research Authors: MINGXI LI, MIN XIA, WEIXIANG CHEN, JIE WANG, YI YIN, CHAO GUO, CHENGCHENG LI, XIAOQIN TANG, HENGLI ZHAO, QIANG TAN, YUJIE CHEN, ZHENGCAI JIA, XIN LIU, HUA FENG Source Type: research

Lithium treatment mitigates white matter injury after intracerebral hemorrhage through brain-derived neurotrophic factor signaling in mice.
Abstract Intracerebral hemorrhage (ICH), a subtype of stroke with high morbidity and mortality, occurs mainly in the basal ganglia and causes white matter injury (WMI), resulting in severe motor dysfunction and poor prognosis in patients. The preservation of the white matter around the hematoma is crucial for motor function recovery, but there is currently no effective treatment for WMI following ICH. Lithium has been widely used for the treatment of bipolar disorder for decades. Although the protective effects of lithium on neurodegenerative diseases and cerebral trauma have been studied in recent years, whether ...
Source: Translational Research : the journal of laboratory and clinical medicine - December 26, 2019 Category: Laboratory Medicine Authors: Li M, Xia M, Chen W, Wang J, Yin Y, Guo C, Li C, Tang X, Zhao H, Tan Q, Chen Y, Jia Z, Liu X, Feng H Tags: Transl Res Source Type: research

Neuroserpin in Bipolar Disorder.
CONCLUSION: Since we detected difference between the patients and the controls, not the disease states, the dysregulation in the neuroserpin gene could be interpreted as a result of the disease itself. PMID: 32003693 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - January 30, 2020 Category: Chemistry Authors: Çınar RK Tags: Curr Top Med Chem Source Type: research

Safety and Tolerability of Ketamine Use in Treatment-Resistant Bipolar Depression Patients with Regard to Central Nervous System Symptomatology: Literature Review and Analysis.
Abstract The current psychopharmacological treatment approaches for major depression focus on monoaminergic interventions, which are ineffective in a large proportion of patients. Globally, treatment-resistant bipolar depression (TRBD) affects up to 33% of depressive patients receiving treatment. Certain needs are still unmet and require new approaches. Many studies are in favor of treatments with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, even in single use, whose effects emerge in minutes to hours post administration. However, little data are available on ketamine performance in TRBD patients ...
Source: Medicina (Kaunas) - February 8, 2020 Category: Universities & Medical Training Authors: Włodarczyk A, Cubała WJ Tags: Medicina (Kaunas) Source Type: research

Association between periodontitis and bipolar disorder: A nationwide cohort study
Whether periodontitis is a risk factor for developing bipolar disorders (BD) has not been investigated. We aimed to determine whether periodontitis is associated with the subsequent development of BD and examine the risk factors for BD among patients with periodontitis. Using ambulatory and inpatient claims data from the National Health Insurance Research Database (NHIRD), we identified 12,337 patients who were aged at least 20 years and newly diagnosed with periodontitis between 2000 and 2004. The date of the first claim with a periodontitis diagnosis was set as the index date. For each patient with periodontitis, 4 subj...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

The association between carotid atherosclerosis and treatment with lithium and antipsychotics in patients with bipolar disorder.
CONCLUSION: Lithium treatment may be associated with less progression in carotid intima-media thickness and the reduced risk for atherosclerosis in adults with bipolar disorder, including those with high cardiovascular disease risk. In addition to age and body mass index, antipsychotics may increase carotid intima-media thickness even in the low cardiovascular disease-risk patients. PMID: 32900219 [PubMed - as supplied by publisher]
Source: The Australian and New Zealand Journal of Psychiatry - September 7, 2020 Category: Psychiatry Authors: Tsai SY, Shen RS, Kuo CJ, Chen PH, Chung KH, Hsiao CY, Huang SH Tags: Aust N Z J Psychiatry Source Type: research

Associations and limited shared genetic aetiology between bipolar disorder and cardiometabolic traits in the UK Biobank
CONCLUSIONS: This large study identified increased phenotypic cardiometabolic abnormalities in BPD participants. It is found that the comorbidity of coronary artery disease may be based on shared genetic aetiology. These results motivate hypothesis-driven research to consider individual cardiometabolic traits rather than a composite metabolic syndrome when attempting to disentangle driving mechanisms of cardiometabolic abnormalities in BPD.PMID:33766158 | DOI:10.1017/S0033291721000945
Source: Psychological Medicine - March 26, 2021 Category: Psychiatry Authors: Anna E F ürtjes Jonathan R I Coleman Jess Tyrrell Cathryn M Lewis Saskia P Hagenaars Source Type: research