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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Neurovascular protection afforded by delayed local hypothermia after transient middle cerebral artery occlusion.
Abstract Therapeutic hypothermia is a robust therapeutic tool in experimental stroke models but its clinical applications are limited. Furthermore, optimal conditions for therapeutic hypothermia, such as, temperature and the initiation and duration of cooling must be individualized. Here, we evaluated the therapeutic effects of delayed local hypothermia, administered for 44 hr after 4 hr of reperfusion in a rat model of transient middle cerebral artery occlusion (tMCAo), using a cooling device that allowed controlled local hypothermia (31°C) in brain. Histological data revealed that local hypothermia significantl...
Source: Current Neurovascular Research - May 1, 2013 Category: Neurology Authors: Kim JH, Seo M, Han HS, Park J, Suk K Tags: Curr Neurovasc Res Source Type: research

Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition.
Conclusions: External cooling-induced shivering and tachycardia are suppressed by TRPV1 activation, but not by TRPM8 inhibition. This suggests that TRPV1 agonists may be combined with external physical cooling to achieve more rapid and effective hypothermia. PMID: 24005250 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 4, 2013 Category: Physiology Authors: Feketa VV, Balasubramanian A, Flores CM, Player MR, Marrelli SP Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Effects of Therapeutic Hypothermia on Left Ventricular Function Assessed by Ultrasound Imaging
Conclusions: Hypothermia induced systolic and diastolic dysfunction, with reduced tolerance to increased heart rate. These findings may have implications for patient management during hypothermia.
Source: Journal of the American Society of Echocardiography - July 26, 2013 Category: Cardiology Authors: Andreas Espinoza, Viesturs Kerans, Anders Opdahl, Helge Skulstad, Per Steinar Halvorsen, Jan Fredrik Bugge, Erik Fosse, Thor Edvardsen Tags: Pre-Clinical Investigation Source Type: research

Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition
In conclusion, external cooling-induced shivering and tachycardia are suppressed by TRPV1 activation, but not by TRPM8 inhibition. This suggests that TRPV1 agonists may be combined with external physical cooling to achieve more rapid and effective hypothermia.
Source: AJP: Regulatory, Integrative and Comparative Physiology - November 1, 2013 Category: Physiology Authors: Feketa, V. V., Balasubramanian, A., Flores, C. M., Player, M. R., Marrelli, S. P. Tags: Obesity, Diabetes and Energy Homeostasis Source Type: research

Clinical applications of targeted temperature management.
Abstract Targeted temperature management (TTM) has been investigated experimentally and used clinically for over 100 years. The initial rationale for the clinical application of TTM, historically referred to as therapeutic hypothermia, was to decrease the metabolic rate, allowing the injured brain time to heal. Subsequent research demonstrated the temperature dependence of diverse cellular mechanisms including endothelial dysfunction, production of reactive oxygen species, and apoptosis. Consequently, modern use of TTM centers on neuroprotection following focal or global neurologic injury. Despite a solid basic sc...
Source: Chest - February 1, 2014 Category: Respiratory Medicine Authors: Perman SM, Goyal M, Neumar RW, Topjian AA, Gaieski DF Tags: Chest Source Type: research

Mannitol-enhanced delivery of stem cells and their growth factors across the blood brain barrier.
MANNITOL-ENHANCED DELIVERY OF STEM CELLS AND THEIR GROWTH FACTORS ACROSS THE BLOOD BRAIN BARRIER. Cell Transplant. 2014 Jan 29; Authors: Gonzales-Portillo GS, Sanberg PR, Franzblau M, Gonzales-Portillo C, Diamandis T, Staples M, Sanberg CD, Borlongan CV Abstract Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions. Currently, clinicians have only tPA available for stroke treatment, and hypothermia for cerebralpalsy. Due to the lack of treatment options, there is a need for novel treatments such as stem cell therapy. Various stem cells includi...
Source: Cell Transplantation - January 29, 2014 Category: Cytology Authors: Gonzales-Portillo GS, Sanberg PR, Franzblau M, Gonzales-Portillo C, Diamandis T, Staples M, Sanberg CD, Borlongan CV Tags: Cell Transplant Source Type: research

Milrinone ameliorates cardiac mechanical dysfunction after hypothermia in an intact rat model.
CONCLUSIONS: Milrinone ameliorated cardiac dysfunction during rewarming from 15°C. The present results suggest that at low core temperatures and during rewarming from such temperatures, pharmacologic efforts to support cardiovascular function is better achieved by substances preventing cyclic AMP breakdown rather than increasing its formation via β-receptor stimulation. PMID: 25224046 [PubMed - as supplied by publisher]
Source: Cryobiology - September 12, 2014 Category: Biology Authors: Dietrichs ES, Kondratiev T, Tveita T Tags: Cryobiology Source Type: research

Deaths attributed to heat, cold, and other weather events in the United States, 2006-2010.
CONCLUSIONS: During 2006-2010, about 2,000 U.S. residents died each year from weather-related causes of death. About 31% of these deaths were attributed to exposure to excessive natural heat, heat stroke, sun stroke, or all; 63% were attributed to exposure to excessive natural cold, hypothermia, or both; and the remaining 6% were attributed to floods, storms, or lightning. Weather-related death rates varied by age, race and ethnicity, sex, and characteristics of decedent's county of residence (median income, region, and urbanization level). Adjustment for region and urbanization decreased the risk of heat-related mortality...
Source: National health statistics reports - November 12, 2014 Category: American Health Tags: Natl Health Stat Report Source Type: research

Effects of local hypothermia on neuronal cell apoptosis after intracerebral hemorrhage in rats
Conclusion These data suggest that local hypothermia induces a reduction in the brain edema and partly reduces neurological deficits along with marked inhibitory effects on MMP-9 and cell apoptosis after ICH.
Source: The Journal of Nutrition, Health and Aging - February 6, 2015 Category: Nutrition Source Type: research

Pharmacologically Induced Hypothermia Attenuates Traumatic Brain Injury in Neonatal Rats.
Abstract Neonatal brain trauma is linked to higher risks of mortality and neurological disability. The use of mild to moderate hypothermia has shown promising potential against brain injuries induced by stroke and traumatic brain injury (TBI) in various experimental models and in clinical trials. Conventional methods of physical cooling, however, are difficult to use in acute treatments and in induction of regulated hypothermia. In addition, general anesthesia is usually required to mitigate the negative effects of shivering during physical cooling. Our recent investigations demonstrate the potential therapeutic b...
Source: Experimental Neurology - February 25, 2015 Category: Neurology Authors: Gu X, Wei ZZ, Espinera A, Lee JH, Ji X, Wei L, Dix TA, Yu SP Tags: Exp Neurol Source Type: research

Complete Resolution of Post-Operative Hemiparesis following Carotid Endarterectomy with Therapeutic Hypothermia: A case study and literature review
We present the case of a 65-year-old woman with a clinical cerebrovascular accident (CVA) following a right carotid endarterectomy who was treated with a 24-hour hypothermia protocol and had a full recovery. The hypothermia protocol utilized on this patient and a review of the literature surrounding hypothermia in the setting of ischemic stroke are presented.
Source: Annals of Vascular Surgery - June 11, 2015 Category: Surgery Authors: Irina Usach, Andreas Sakopoulos, Hossein Razavi Source Type: research

Moderate Versus Deep Hypothermia With Unilateral Selective Antegrade Cerebral Perfusion for Acute Type A Dissection.
CONCLUSIONS: Moderate HCA with uSACP is an effective circulation management strategy that provides excellent cerebral and visceral protection during emergent ATAAD repair. In the setting of antegrade cerebral perfusion, deep hypothermia does not provide any additional benefit. PMID: 26233273 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - July 30, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Leshnower BG, Thourani VH, Halkos ME, Sarin EL, Keeling WB, Lamias MJ, Guyton RA, Chen EP Tags: Ann Thorac Surg Source Type: research

Moderate Versus Deep Hypothermia With Unilateral Selective Antegrade Cerebral Perfusion for Acute Type A Dissection
Conclusions Moderate HCA with uSACP is an effective circulation management strategy that provides excellent cerebral and visceral protection during emergent ATAAD repair. In the setting of antegrade cerebral perfusion, deep hypothermia does not provide any additional benefit.
Source: The Annals of Thoracic Surgery - October 30, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Twenty four hours hypothermia has temporary efficacy in reducing brain infarction and inflammation in aged rats
Stroke is a major cause of disability for which no neuroprotective measures are available. Age is the principal nonmodifiable risk factor for this disease. Previously, we reported that exposure to hydrogen sulfide (H2S) for 48 hours post-stroke lowers whole body temperature and confers neuroprotection in aged animals. Since the duration of hypothermia in most clinical trials is between 24 and 48 hrs, we questioned whether 24 hr exposure to gaseous hypothermia confers the same neuroprotective efficacy as 48 hr exposure.
Source: Neurobiology of Aging - November 19, 2015 Category: Neuroscience Authors: Raluca Elena Sandu, Ana-Maria Buga, Adrian Tudor Balseanu, Mihai Moldovan, Aurel Popa-Wagner Source Type: research

Influence of therapeutic hypothermia on regeneration after cerebral ischemia.
Authors: Yenari MA, Han HS Abstract The protective effect of therapeutic hypothermia in cerebral ischemia is well accepted in experimental models, and some clinical studies show that there is benefit in humans as well. Long-term observations in animal and clinical studies have documented recovery of neurological function following hypothermia treatment. Diminished damage by hypothermic protection should contribute to the recovery in many ways, but hypothermia appears to enhance regeneration of brain tissue as well. Since regeneration of the brain after damage initiates within hours and is active days and weeks afte...
Source: Frontiers of Neurology and Neuroscience - December 2, 2015 Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research