Milrinone ameliorates cardiac mechanical dysfunction after hypothermia in an intact rat model.

CONCLUSIONS: Milrinone ameliorated cardiac dysfunction during rewarming from 15°C. The present results suggest that at low core temperatures and during rewarming from such temperatures, pharmacologic efforts to support cardiovascular function is better achieved by substances preventing cyclic AMP breakdown rather than increasing its formation via β-receptor stimulation. PMID: 25224046 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25224046?dopt=Abstract

Source: Cryobiology - September 12, 2014 Category: Biology Authors: Dietrichs ES, Kondratiev T, Tveita T Tags: Cryobiology Source Type: research