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Total 432 results found since Jan 2013.

Abstract 350: Impact of Acute Kidney Injury on Outcomes of Patients Admitted with Unstable Angina in United States, Years 2005-2011 Session Title: Poster Session III
Conclusions: In patients with UA, AKI is associated with significantly higher rates of in-hospital complications and mortality.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Awan, M. U., Malik, A., Akram, Y., Adil, M. M. Tags: Session Title: Poster Session III Source Type: research

Clinical significance of urinary liver-type fatty acid-binding protein as a predictor of ESRD and CVD in patients with CKD
Conclusions Urinary L-FABP may be a useful prognostic marker of progression to ESRD and the onset of CVD in patients with CKD.
Source: Clinical and Experimental Nephrology - July 19, 2015 Category: Urology & Nephrology Source Type: research

The “Sapienza University Mortality and Morbidity Event Rate (SUMMER) Study in Diabetes”: Study Protocol
Discussion The “SUMMER study in diabetes” is aimed at identifying new molecular promoters of mortality and major vascular events in patients with T2DM. Most likely, these novel pathogenic factors will be instrumental for unraveling new pathways underlying such dramatic events. In addition, they will also be used as additional markers to increase the performance of already existing risk-scoring models in predicting the above mentioned outcomes in T2DM, as well as in setting up new preventive and treatment strategies, possibly tailored to specific pathogenic backgrounds.
Source: Nutrition, Metabolism and Cardiovascular Diseases - October 9, 2015 Category: Nutrition Source Type: research

Timing of Dialysis Initiation, Duration and Frequency of Hemodialysis Sessions, and Membrane Flux: A Systematic Review for a KDOQI Clinical Practice Guideline
Conclusions Limited data indicate that earlier dialysis therapy initiation and more frequent and longer hemodialysis did not improve clinical outcomes compared to conventional hemodialysis.
Source: American Journal of Kidney Diseases - October 21, 2015 Category: Urology & Nephrology Source Type: research

Redo aortic valve surgery versus transcatheter valve-in-valve implantation for failing surgical bioprosthetic valves: consecutive patients in a single-center setting.
CONCLUSIONS: The present investigation shows that both groups, irrespective of different baseline comorbidities, show very good early clinical outcomes. While redo surgery is still the standard of care, a subgroup of patients may profit from the transcatheter valve-in-valve procedure. PMID: 26543594 [PubMed]
Source: Journal of Thoracic Disease - November 8, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Cardiac risk stratification in patients undergoing endovascular aortic repair.
Authors: Biagi P, de Donato G, Setacci C Abstract Endovascular aortic repair (EVAR) for abdominal aortic aneurysms (AAA) is the preferred first treatment option in case of patients with advanced age and/or fit anatomy owing to shorter length of in hospital staying, less complications or laparotomy-related re- interventions, and lower initial costs. Although it is a less-invasive intervention, EVAR entails a risk similar to that of open aortic procedures for medical comorbidities, and a perioperative clinical evaluation is mandatory to minimize the early and late cardiovascular risk. In this brief review the determi...
Source: Minerva Cardioangiologica - November 18, 2015 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research

Clinical Outcomes of Drug-Eluting Stents vs. Bare-Metal Stents in Acute Myocardial Infarction Patients Under Dialysis　- A Nationwide Cohort Study.
CONCLUSIONS: Among AMI patients on dialysis undergoing percutaneous coronary interventions, DES implantation significantly reduced the risk of recurrent MI, CV death and all-cause mortality compared with BMS implantation. PMID: 26581755 [PubMed - as supplied by publisher]
Source: Circulation Journal - November 19, 2015 Category: Cardiology Authors: Chen DY, Mao CT, Tsai ML, Hsieh MJ, Lin YS, Cherng WJ, Wen MS, Wang CH, Hsieh IC, Hung MJ, Chen CC, Chen TH Tags: Circ J Source Type: research

Comparative outcomes of predominant facility-level use of ferumoxytol versus other intravenous iron formulations in incident hemodialysis patients
Conclusions In incident HD patients, ferumoxytol showed similar short- to mid-term safety profiles with regard to cardiovascular, infectious and mortality outcomes compared with the more commonly used intravenous iron formulations IS and FG.
Source: Nephrology Dialysis Transplantation - November 23, 2015 Category: Urology & Nephrology Authors: Airy, M., Mandayam, S., Mitani, A. A., Chang, T. I., Ding, V. Y., Brookhart, M. A., Goldstein, B. A., Winkelmayer, W. C. Tags: Intra- and extracorporeal treatments of kidney failure Source Type: research

Acute kidney injury (AKI) outcome, a predictor of long-term major adverse cardiovascular events (MACE).
CONCLUSION: Complete renal recovery after an episode of AKI in patients with normal baseline kidney function is associated with a lower risk of long-term MACE when compared with those who did not fully recover. PMID: 26636328 [PubMed - as supplied by publisher]
Source: Clinical Nephrology - December 4, 2015 Category: Urology & Nephrology Authors: Omotoso BA, Abdel-Rahman EM, Xin W, Ma JZ, Scully KW, Arogundade FA, Balogun RA Tags: Clin Nephrol Source Type: research

Time‐varying effect modeling with longitudinal data truncated by death: conditional models, interpretations, and inference
Recent studies found that infection‐related hospitalization was associated with increased risk of cardiovascular (CV) events, such as myocardial infarction and stroke in the dialysis population. In this work, we develop time‐varying effects modeling tools in order to examine the CV outcome risk trajectories during the time periods before and after an initial infection‐related hospitalization. For this, we propose partly conditional and fully conditional partially linear generalized varying coefficient models (PL‐GVCMs) for modeling time‐varying effects in longitudinal data with substantial follow‐up truncation ...
Source: Statistics in Medicine - December 9, 2015 Category: Statistics Authors: Jason P. Estes, Danh V. Nguyen, Lorien S. Dalrymple, Yi Mu, Damla Şentürk Tags: Research Article Source Type: research

COGNITIVE-HD study: protocol of an observational study of neurocognitive functioning and association with clinical outcomes in adults with end-stage kidney disease treated with haemodialysis
Introduction The prevalence of cognitive impairment may be increased in adults with end-stage kidney disease compared with the general population. However, the specific patterns of cognitive impairment and association of cognitive dysfunction with activities of daily living and clinical outcomes (including withdrawal from treatment) among haemodialysis patients remain incompletely understood. The COGNITIVE impairment in adults with end-stage kidney disease treated with HemoDialysis (COGNITIVE-HD) study aims to characterise the age-adjusted and education-adjusted patterns of cognitive impairment (using comprehensive testing...
Source: BMJ Open - December 9, 2015 Category: Journals (General) Authors: Palmer, S. C., Ruospo, M., Barulli, M. R., Iurillo, A., Saglimbene, V., Natale, P., Gargano, L., Murgo, A. M., Loy, C., van Zwieten, A., Wong, G., Tortelli, R., Craig, J. C., Johnson, D. W., Tonelli, M., Hegbrant, J., Wollheim, C., Logroscino, G., Strippo Tags: Open access, Epidemiology, Neurology Protocol Source Type: research

Early versus delayed erythropoietin for the anaemia of end-stage kidney disease.
CONCLUSIONS: We found no evidence to assess the benefits and harms of early versus delayed EPO for the anaemia of ESKD. PMID: 26671531 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - December 16, 2015 Category: Journals (General) Authors: Coronado Daza J, Martí-Carvajal AJ, Ariza García A, Rodelo Ceballos J, Yomayusa González N, Páez-Canro C, Loza Munárriz C, Urrútia G Tags: Cochrane Database Syst Rev Source Type: research

Coronary Revascularization in Chronic and End-Stage Renal Disease: A Systematic Review and Meta-analysis
Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) on dialysis have an increased risk for cardiovascular mortality and morbidity secondary to occlusive coronary artery disease. Optimal revascularization strategy is unclear in this high-risk population. We have performed a meta-analysis to compare coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) in patients with ESRD and CKD. We searched PubMed, Ovid, MEDLINE, CINAHL, and EMBASE (1980–2013) and found 17 trials (N = 33,584) in the ESRD arm and 6 studies (n = 15,493) in the CKD arm. Two investigators independe...
Source: American Journal of Therapeutics - January 1, 2016 Category: Drugs & Pharmacology Tags: Original Articles Source Type: research

Multicentre randomized controlled trial of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker withdrawal in advanced renal disease: the STOP-ACEi trial
Background Blood pressure (BP) control and reduction of urinary protein excretion using agents that block the renin–angiotensin aldosterone system are the mainstay of therapy for chronic kidney disease (CKD). Research has confirmed the benefits in mild CKD, but data on angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) use in advanced CKD are lacking. In the STOP-ACEi trial, we aim to confirm preliminary findings which suggest that withdrawal of ACEi/ARB treatment can stabilize or even improve renal function in patients with advanced progressive CKD. Methods The STOP-ACEi trial (tri...
Source: Nephrology Dialysis Transplantation - January 25, 2016 Category: Urology & Nephrology Authors: Bhandari, S., Ives, N., Brettell, E. A., Valente, M., Cockwell, P., Topham, P. S., Cleland, J. G., Khwaja, A., El Nahas, M. Tags: Chronic Kidney Disease Source Type: research

Beat Depression to Stay Healthier & Live Longer: A Guide for Older Adults & Their Families
Many people find the reality of getting older depressing. And depression itself often comes with a stigma. So when we talk about depression and aging combined, what results is a very complicated — and often hard to treat — issue. Gary S. Moak, former president of the American Association for Geriatric Psychiatry, has written a new book to help. Beat Depression to Stay Healthier and Live Longer: A Guide for Older Adults and Their Families combines Moak’s years of experience working with elderly populations with the latest research on depression. Moak begins by defining depression and clarifying many of the myths...
Source: Psych Central - January 28, 2016 Category: Psychiatry Authors: Claire Nana Tags: Aging Antidepressants Book Reviews Depression Family General Psychology Self-Help Seniors Treatment antidepressants for elderly patients antidepressants for old people beat depression depression and aging depression geriatric Source Type: news