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Condition: Liver Disease
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Total 212 results found since Jan 2013.

Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells.
Authors: Wang H, Liu S, Wang Y, Chang B, Wang B Abstract Nod-like receptor protein 3 (NLRP3) inflammasome has been implicated in alcoholic liver disease. Chronic alcohol consumption enhances gut permeability and causes microbial translocation. The present study explored the activation of the NLRP3 inflammasome by Escherichia coli RNA in hepatic stellate cells (HSCs), and the potential role of NLRP3 inflammasome in hepatic fibrosis. E. coli RNA transfection induced HSC-T6 cells to secrete and express mature interleukin-1 beta (IL-1β), which was abolished by NLRP3 siRNA pretreatment. In addition, E. coli RNA transfe...
Source: Bosnian Journal of Basic Medical Sciences - January 20, 2016 Category: Journals (General) Tags: Bosn J Basic Med Sci Source Type: research

miR-212 downregulation contributes to the protective effect of exercise against non-alcoholic fatty liver via targeting FGF-21.
In this study, normal or high-fat diet (HF) mice were either subjected to a 16-week running program or kept sedentary. Exercise attenuated liver steatosis in HF mice. MicroRNA array and qRT-PCR demonstrated that miR-212 was overexpressed in HF liver, while reduced by exercise. Next, we investigated the role of miR-212 in lipogenesis using HepG2 cells with/without long-chain fatty acid treatment (±FFA). FFA increased miR-212 in HepG2 cells. Moreover, miR-212 promoted lipogenesis in HepG2 cells (±FFA). Fibroblast growth factor (FGF)-21, a key regulator for lipid metabolism, was negatively regulated by miR-212 at protein le...
Source: J Cell Mol Med - December 9, 2015 Category: Molecular Biology Authors: Xiao J, Bei Y, Liu J, Dimitrova-Shumkovska J, Kuang D, Zhou Q, Li J, Yang Y, Xiang Y, Wang F, Yang C, Yang W Tags: J Cell Mol Med Source Type: research

Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway
Autophagy plays an important role in liver triglyceride (TG) metabolism. Inhibition of autophagy could reduce the clearance of TG in the liver. Hydrogen sulfide (H2S) is a potent stimulator of autophagic flux. Recent studies showed H2S is protective against hypertriglyceridemia (HTG) and noalcoholic fatty liver disease (NAFLD), while the mechanism remains to be explored. Here, we tested the hypothesis that H2S reduces serum TG level and ameliorates NAFLD by stimulating liver autophagic flux by the AMPK-mTOR pathway. The level of serum H2S in patients with HTG was lower than that of control subjects. Sodium hydrosulfide (Na...
Source: AJP: Endocrinology and Metabolism - December 1, 2015 Category: Endocrinology Authors: Sun, L., Zhang, S., Yu, C., Pan, Z., Liu, Y., Zhao, J., Wang, X., Yun, F., Zhao, H., Yan, S., Yuan, Y., Wang, D., Ding, X., Liu, G., Li, W., Zhao, X., Liu, Z., Li, Y. Tags: Articles Source Type: research

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ
Publication date: Available online 23 November 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Jinbiao Chen, Wei Wang, Yanfei Qi, Dominik Kaczorowski, Geoffrey W. McCaughan, Jennifer R. Gamble, Anthony S. Don, Xin Gao, Mathew A. Vadas, Pu Xia Sphingolipid metabolites have emerged playing important roles in the pathogenesis of nonalcoholic fatty liver disease, whereas the underlying mechanism remains largely unknown. In the present study, we provide both in vitro and in vivo evidence showing a pathogenic role of sphingosine kinase 1 (SphK1) in hepatocellular stea...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - November 25, 2015 Category: Lipidology Source Type: research

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ.
Abstract Sphingolipid metabolites have emerged playing important roles in the pathogenesis of nonalcoholic fatty liver disease, whereas the underlying mechanism remains largely unknown. In the present study, we provide both in vitro and in vivo evidence showing a pathogenic role of sphingosine kinase 1 (SphK1) in hepatocellular steatosis. We found that levels of SphK1 expression were significantly increased in steatotic hepatocytes. Enforced overexpression of SphK1 or treatment with sphingosine 1-phosphate (S1P) markedly enhanced hepatic lipid accumulation. In contrast, the siRNA-mediated knockdown of SphK1 or S1P...
Source: Biochimica et Biophysica Acta - November 23, 2015 Category: Biochemistry Authors: Chen J, Wang W, Qi Y, Kaczorowski D, McCaughan GW, Gamble JR, Don AS, Gao X, Vadas MA, Xia P Tags: Biochim Biophys Acta Source Type: research

Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via AMPK- mTOR pathway.
Abstract Autophagy plays an important role in liver triglyceride (TG) metabolism. Inhibition of autophagy could reduce the clearance of TG in the liver. Hydrogen sulfide (H2S) is a potent stimulator of autophagic flux. Recent studies showed H2S is protective against Hypertriglyceridemia (HTG) and noalcoholic fat liver disease (NAFLD), while the mechanism remains to be explored. Here we test the hypothesis that H2S reduces serum TG level and ameliorates NAFLD through stimulating liver autophagic flux by AMPK-mTOR pathway. The level of serum H2S in patients with HTG was lower than that of control subjects. Sodium hy...
Source: Am J Physiol Endocri... - October 6, 2015 Category: Endocrinology Authors: Sun L, Zhang S, Yu C, Pan Z, Liu Y, Zhao J, Wang X, Yun F, Zhao H, Yan S, Yuan Y, Wang D, Ding X, Li W, Liu G, Zhao X, Liu Z, Li Y Tags: Am J Physiol Endocrinol Metab Source Type: research

Tetramethylpyrazine prevents ethanol-induced hepatocyte injury via activation of nuclear factor erythroid 2-related factor 2
Publication date: 15 November 2015 Source:Life Sciences, Volume 141 Author(s): Chunfeng Lu, Yuanyuan Jiang, Feng Zhang, Jiangjuan Shao, Li Wu, Xiafei Wu, Naqi Lian, Lianyun Chen, Huanhuan Jin, Qin Chen, Yin Lu, Shizhong Zheng Aims Inhibiting the major features of alcoholic liver disease (ALD) such as lipid accumulation and oxidative stress is a promising strategy of treating ALD. Tetramethylpyrazine (TMP) has curative effects on various diseases. However, the effects of TMP on ethanol-induced hepatocyte injury and the related mechanisms remain unclear. The aim of this study is to elucidate the effects of TMP ...
Source: Life Sciences - October 4, 2015 Category: Biology Source Type: research

Post-transcriptional HAMP Regulation by PA Is Mediated via HuR Gene Regulation
In conclusion, lipids mediate post-transcriptional regulation of HAMP throughPKC- and HuR-dependent mechanisms.
Source: Journal of Biological Chemistry - October 2, 2015 Category: Chemistry Authors: Lu, S., Mott, J. L., Harrison-Findik, D. D. Tags: Metabolism Source Type: research

Amelioration of nonalcoholic fatty liver disease by hepatic stimulator substance via preservation of carnitine palmitoyl transferase-1 activity
In conclusion, HSS reduces lipotoxicity to mitochondria most likely via preservation of CPT-1.
Source: AJP: Cell Physiology - August 15, 2015 Category: Cytology Authors: Xiao, W., Ren, M., Zhang, C., Li, S., An, W. Tags: ARTICLES Source Type: research

Long non-coding RNAs era in liver cancer.
Authors: Guerrieri F Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies leading to high mortality rates in the general population and the sixth most common cancer worldwide. HCC is characterized by deregulation of multiple genes and signalling pathways. These genetic effects can involve both protein coding genes as well as non-coding RNA genes. Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nt, constituting a subpopulation of ncRNAs. Their biological effects are not well understood compared to small non-coding RNA (microRNAs), but they have been recently recognized to exe...
Source: World Journal of Hepatology - August 12, 2015 Category: Gastroenterology Tags: World J Hepatol Source Type: research

RNAi in murine hepatocytes: the agony of choice-a study of the influence of lipid-based transfection reagents on hepatocyte metabolism.
In conclusion, these findings demonstrate that the choice of non-viral siRNA delivery agent is critical in hepatocytes. This should be remembered, especially if RNA silencing is used for studying hepatic lipid homeostasis and its regulation. PMID: 26233687 [PubMed - as supplied by publisher]
Source: Archives of Toxicology - August 2, 2015 Category: Toxicology Authors: Böttger J, Arnold K, Thiel C, Rennert C, Aleithe S, Hofmann U, Vlaic S, Sales S, Shevchenko A, Matz-Soja M Tags: Arch Toxicol Source Type: research

Hepatic TLR4 Signaling in Obese NAFLD.
CONCLUSION: TLR4 expression is up-regulated in a large cohort of NASH patients, when compared to those with NAFL, and this occurs within the setting of increased LPS and fatty acids. PMID: 26113297 [PubMed - as supplied by publisher]
Source: Am J Physiol Gastroi... - June 25, 2015 Category: Gastroenterology Authors: Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Amelioration of Non-alcoholic Fatty Liver Disease by Hepatic Stimulator Substance via Preservation of Carnitine Palmitoyl Transferase-1 Activity.
In conclusion, HSS reduces lipotoxicity to mitochondria most likely via preservation of CPT-1. PMID: 26108664 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - June 24, 2015 Category: Cytology Authors: Xiao W, Ren M, Zhang C, Li S, An W Tags: Am J Physiol Cell Physiol Source Type: research

Specific hepatic delivery of procollagen α1(I) siRNA in lipid‐like nanoparticles resolves liver fibrosis
Conclusion: The data reported in the present study extensively show that LNP‐siCol1a1 specifically reduce total hepatic collagen content without detectable side effects, potentially qualifying as a therapy for fibrotic liver diseases. This article is protected by copyright. All rights reserved.
Source: Hepatology - June 10, 2015 Category: Internal Medicine Authors: Carolina Jiménez Calvente, Alfica Sehgal, Yury Popov, Yong Ook Kim, Victor Zevallos, Ugur Sahin, Mustafa Diken, Detlef Schuppan Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research

Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor γ in human hepatocytes and increases lipid accumulation.
In this study, we evaluated the differences between MGAT subtypes and their association with peroxisome proliferator-activated receptor γ (PPARγ), a regulator of mouse MGAT1 expression. In human primary hepatocytes, basal expression of MGAT1 was lower than that of MGAT2 or MGAT3, but was strongly induced by PPARγ overexpression. A luciferase assay as well as an electromobility shift assay revealed that human MGAT1 promoter activity is driven by PPARγ by direct binding to at least two regions of the promoter in 293T and HepG2 cells. Moreover, siRNA-mediated suppression of MGAT1 expression significantly attenuated lipid ...
Source: Biochemical and Biophysical Research communications - March 30, 2015 Category: Biochemistry Authors: Yu JH, Lee YJ, Kim HJ, Choi H, Choi Y, Seok JW, Kim JW Tags: Biochem Biophys Res Commun Source Type: research