Filtered By:
Specialty: Drugs & Pharmacology
Condition: Autoimmune Disease

This page shows you your search results in order of date.

Order by Relevance | Date

Total 18 results found since Jan 2013.

Osteopontin in autoimmune disorders: current knowledge and future perspective
AbstractOsteopontin (OPN) is a multifunctional cytokine and adhesion molecule, as well as an unusual regulator for both innate and adaptive immune responses. Several immune cells can produce OPN, including dendritic cells (DCs), macrophages, and T lymphocytes. OPN expression is reported to be increased in a wide range of disorders, including autoimmunity, cancer, and allergy. The overexpression of OPN in several autoimmune disorders, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), Type 1 diabetes (T1D), inflammatory bowel disease (IBD), Sj ögren’s, and myasthenia gravis, h...
Source: Inflammopharmacology - March 2, 2022 Category: Drugs & Pharmacology Source Type: research

Exacerbation of Allergic Airway Inflammation in Mice Lacking ECTO-5 ′-Nucleotidase (CD73)
The airways are a target tissue of type I allergies and atopy is the main etiological factor of bronchial asthma. A predisposition to allergy and individual response to allergens are dependent upon environmental and host factors. Early studies performed to clarify the role of extracellular adenosine in the airways highlighted the importance of adenosine-generating enzymes CD73, together with CD39, as an innate protection system against lung injury. In experimental animals, deletion of CD73 has been associated with immune and autoimmune diseases. Our experiments have been performed to investigate the role of CD73 in the ass...
Source: Frontiers in Pharmacology - November 30, 2020 Category: Drugs & Pharmacology Source Type: research

Linking autoantigen properties to mechanisms of immunity.
Abstract Antigen-specific immunotherapies (ASIT) present compelling potential for introducing precision to the treatment of autoimmune diseases where nonspecific, global immunosuppression is currently the only treatment option. Central to ASIT design is the delivery of autoantigen, which parallels allergy desensitization approaches. Clinical success in tolerizing allergen-specific responses spans longer than a century, but autoimmune ASITs have yet to see an FDA-approved breakthrough. Allergens and autoantigens differ substantially in physicochemical properties, and these discrepancies influence the nature of thei...
Source: Advanced Drug Delivery Reviews - April 19, 2020 Category: Drugs & Pharmacology Authors: Griffin JD, Song JY, Sestak JO, DeKosky BJ, Berkland CJ Tags: Adv Drug Deliv Rev Source Type: research

Eosinophils, a Jack of All Trades in Immunity: Therapeutic Approaches for Correcting their Functional Disorders.
CONCLUSION: Eosinophils are cells endowed with multiple functions and their modulation with monoclonal antibodies and nutraceuticals may be effective in the treatment of chronic disease. Other: Mostly, in asthma, eosinophils provoke airway damage via release of granule contents and IL-13 with mucus hypersecretion and differentiation of Goblet cells. Then, tissue remodeling follows with secretion of transforming growth factor-β. Eosinophils are able to kill helminth larvae acting as antigen presenting cells with involvement of T helper (h)-2 cells and subsequent antibody response. However, they also exert pro-worm activity...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 10, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma
Publication date: March 2020Source: Biomedicine & Pharmacotherapy, Volume 123Author(s): Abdolreza Esmaeilzadeh, Safa Tahmasebi, Seyyed Shamsadin AthariAbstractDespite the current advancements, cancer treatment approaches have limitations restricting their cure rate. Immunotherapy techniques are among novel and promising cancer therapeutic approaches. Therapeutic antibodies and adoptive cell therapy (ACT) are the main branches of immunotherapy. T lymphocytes and genetically engineered cells are among important cells which can be used in ACT. This review has focused on recent advances in engineered cell-based immunotherapy b...
Source: Biomedicine and Pharmacotherapy - December 26, 2019 Category: Drugs & Pharmacology Source Type: research

Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway
Conclusion In summary, we demonstrated that geniposide alleviated GC-induced osteogenic suppression in MC3T3-E1 cells. The effects of geniposide were at least partially associated with activating ERK signaling pathway via GLP-1 receptor. Geniposide might be a potential therapeutic agent for protection against GC-induced osteoporosis. Author Contributions BX, DX, CZ, and LW participated in research design. BX, JW, YL, XW, and ZZ conducted the experiments. BX, DX, and LW contributed new reagents or analytic tools and wrote or contributed to the writing of the manuscript. BX, JW, CZ, and DX performed the data analysis. Fu...
Source: Frontiers in Pharmacology - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Focused Ultrasound Improves NK-92MI Cells Infiltration Into Tumors
Conclusion In conclusion, we demonstrated that the combination of FUS and microbubbles could increase the NK-92MI cells’ infiltration into tumors in this study. The combination of FUS and NK-92MI had a much better therapeutic effect when compared with the PBS group, but no superior therapeutic effect when compared with the NK-92MI group. In total, FUS and microbubbles can improve NK cells’ infiltration into tumors, but future work is still needed to improve NK-92MI cells’ delivery efficiency for solid tumor treatment. Ethics Statement This study was carried out in accordance with the recommendations...
Source: Frontiers in Pharmacology - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Qingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis
Conclusion Via a HPLC system and a BATMAN-TCM platform, for the first time we performed detailed HPLC fingerprint analysis and network pharmacology studies of QP ointment. By in-depth animal and molecular analysis, we identified a number of chronic dermatitis-associated Th1/2 cytokines, itch mediators, and cellular signaling pathways in the skin, DRG and serum for QP to treat the inflammation and chronic itch associated with ACD. Our data clearly suggested, upon stimulation, cytokines and itch-related mediators are released from the skin and neuronal tissues, and QP could effectively work on both the skin and sensory neur...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research

Targets of monoclonal antibodies for immunological diseases.
Abstract Immunological disorders such as allergy, autoimmune diseases, auto-inflammatory syndromes and immunological deficiency syndromes are difficult to treat with chemical drugs. Recently, many monoclonal antibodies targeting various molecules including interleukin, tumor necrosis factor-α, cluster of differentiation, integrins, complement C5 and B lymphocyte stimulator are clinically available and give a hope to patients suffering from these intractable diseases. Here, we selected twenty-seven monoclonal antibodies approved by US FDA since 1997 and they are classified according to their target molecules. Alth...
Source: Archives of Pharmacal Research - November 13, 2018 Category: Drugs & Pharmacology Authors: Yoo SM, Chung SH Tags: Arch Pharm Res Source Type: research

Transdermal immunomodulation: Principles, advances, and perspectives.
Abstract Immunomodulation, manipulation of the immune responses towards an antigen, is a promising strategy to treat cancer, infectious diseases, allergies, and autoimmune diseases, among others. Unique features of the skin including the presence of tissue-resident immune cells, ease of access and connectivity to other organs makes it a unique target organ for immunomodulation. In this review, we summarize advances in transdermal delivery of agents for modulating the immune responses for vaccination as well as tolerization. The biological foundation of skin-based immunomodulation and challenges in its implementati...
Source: Advanced Drug Delivery Reviews - March 28, 2018 Category: Drugs & Pharmacology Authors: Zhao Z, Ukidve A, Dasgupta A, Mitragotri S Tags: Adv Drug Deliv Rev Source Type: research

The long ‐term effects of faecal microbiota transplantation for gastrointestinal symptoms and general health in patients with recurrent Clostridium difficile infection
ConclusionOur study highlights that FMT is a durable, safe and acceptable treatment option for patients with recurrent C. difficile infection also in long term, and it shows potential benefits over antimicrobial treatment.
Source: Alimentary Pharmacology and Therapeutics - December 11, 2017 Category: Drugs & Pharmacology Authors: J. Jalanka, A. Hillamaa, R. Satokari, E. Mattila, V. ‐J. Anttila, P. Arkkila Tags: ORIGINAL ARTICLE Source Type: research

Immunomodulatory potential of nanocurcumin-based formulation
AbstractVitamins, minerals, and nanocurcumin play a substantial role in various nutraceutical/pharmaceutical formulations that are widely used in therapeutics, cosmetics, and dietary supplements. The current study aimed to investigate the comparative in vitro immunomodulatory effect of a novel nanocurcumin-based formulation with curcumin in LPS-induced cytokine expression, NK cells ’ activity, and phagocytosis. The proinflammatory cytokines (TNF-α, IL-1β, and MIP-1α) and NK cells’ activity were measured in cell supernatants using ELISA assay; however, phagocytosis activity was performed using colorimetric analysis. ...
Source: Inflammopharmacology - September 18, 2017 Category: Drugs & Pharmacology Source Type: research

Immune competent human skin disease models.
Abstract All skin disease has an underlying immune component. Due to differences in animal and human immunology, the majority of drugs fail in the pre-clinical and clinical testing phase. Therefore animal alternative methods that incorporate human immunology into in vitro skin disease models are required to move the field forward. This review summarizes the progress, using examples from fibrosis, autoimmune diseases, psoriasis, cancer and contact allergy. The emphasis is on co-cultures and 3D-organotypic models. Our conclusion is that current models are inadequate and future developments with immune competent skin...
Source: Drug Discovery Today - June 1, 2016 Category: Drugs & Pharmacology Authors: Bergers LI, Reijnders CM, van den Broek LJ, Spiekstra SW, De Gruijl TD, Weijers EM, Gibbs S Tags: Drug Discov Today Source Type: research

No evidence for hydrolysed infant formula in allergy prevention
Researchers find no protective effect of hydrolysed formula against allergic and autoimmune disease, conflicting with international guidelines.
Source: Clinical Pharmacist - March 15, 2016 Category: Drugs & Pharmacology Source Type: research

Combining Antigen and Immunomodulators: Emerging Trends in Antigen-Specific Immunotherapy for Autoimmunity.
Abstract A majority of current therapies for autoimmune diseases are general immunosuppressants, which can compromise patient response to opportunistic infection. The possibility of using antigen-specific immunotherapy (ASIT) to selectively disarm autoimmune diseases, without suppressing the global immune response, would be a transformative therapy for patients. ASIT has been used historically in allergy hyposensitization therapy to induce tolerance to an allergen. Similar strategies to induce immune tolerance towards autoantigens responsible for autoimmune disease have been attempted, but have yielded limited cli...
Source: Advanced Drug Delivery Reviews - November 3, 2015 Category: Drugs & Pharmacology Authors: Northrup L, Christopher MA, Sullivan BP, Berkland C Tags: Adv Drug Deliv Rev Source Type: research