Triple targeted therapy for advanced bowel cancer improves survival
Patients with metastatic colorectal cancer who have a BRAF mutation have improved survival after treatment with three targeted therapies instead of standard chemotherapy, results from a phase III trial have shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - August 23, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluating the first NHS-funded sore throat test and treat service in the UK
In Wales, people with a sore throat may be offered advice and symptomatic treatment free of charge in community pharmacies through the common ailment service (CAS). However, antibiotics cannot be supplied and this can limit patients ’ perceived value of the service. As a result, some patients continue to seek a GP appointment when they have a sore throat. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - August 14, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacists must embrace pharmacogenetic services before other professions beat them to it
Multidisciplinary genetic testing services will help patients receive more targeted medicines, and pharmacists are the obvious healthcare professional to lead them. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - August 14, 2019 Category: Drugs & Pharmacology Source Type: research

Pain or insomnia main reasons for cannabis use in those without medical certificate
Customers who buy cannabis from “adult use” dispensaries, where no medical certificate is required, commonly report that they use it for pain relief or to help them sleep. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - August 6, 2019 Category: Drugs & Pharmacology Source Type: research

Most antidepressants reduce mortality for patients with diabetes and depression
Use of certain antidepressants to treat depression in patients with diabetes is associated with a reduction in mortality, according to a population-based study. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - August 2, 2019 Category: Drugs & Pharmacology Source Type: research

Low vitamin D status in early life linked to future high blood pressure
Children with persistently low plasma vitamin D levels at birth and in early childhood have an increased risk of elevated systolic blood pressure later in childhood, research has suggested. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 30, 2019 Category: Drugs & Pharmacology Source Type: research

Efficacy of tramadol reduced by concurrent use of some antidepressants
Taking certain antidepressants reduces the efficacy of the opioid medicine tramadol, according to research published in  Pharmacotherapy. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

Statin treatment associated with reduced risk of glaucoma
Receiving statin treatment for five years or more is associated with a 21% reduced risk of primary glaucoma, research has shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 23, 2019 Category: Drugs & Pharmacology Source Type: research

Heart failure, older people and frailty
Diagnosis of heart failure and frailty can often be masked by other long-term conditions, making the delivery of treatment goals complicated. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 12, 2019 Category: Drugs & Pharmacology Source Type: research

SGLT2 inhibitor lowers risk of kidney failure in type 2 diabetes
Patients with type 2 diabetes mellitus and chronic kidney disease have a lower risk of kidney failure and cardiovascular events if they are treated with canagliflozin, research has confirmed. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 11, 2019 Category: Drugs & Pharmacology Source Type: research

Testosterone deficiency: diagnosis, assessment and treatment
Male hypogonadism can significantly affect health and quality of life; however, diagnosis and management can be challenging. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 10, 2019 Category: Drugs & Pharmacology Source Type: research

Taking an STP approach to improving the pharmacy workforce
Developing a sustainable, high quality pharmacy workforce is essential to delivering services in a complex and evolving healthcare environment, particularly as more opportunities arise for pharmacists to take extended roles. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 10, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacists must work with others to roll back polypharmacy culture
The new English Desprescribing Network will bring together healthcare professionals and researchers to stamp out medicine-related harm. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 9, 2019 Category: Drugs & Pharmacology Source Type: research

App helps patients cut opioid use after knee replacement
Patients who underwent knee replacement who used an app to monitor their  analgesic use had better pain control and took fewer opioids post surgery, study results show. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 8, 2019 Category: Drugs & Pharmacology Source Type: research

Concerns raised over non-medical alprazolam use
The benzodiazepine alprazolam is being obtained for non-medical use in the UK, particularly among young people, a survey has found. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 5, 2019 Category: Drugs & Pharmacology Source Type: research

Immunotherapy delays type 1 diabetes mellitus in high-risk individuals
Certain individuals at high risk of developing type 1 diabetes mellitis can delay progression to clinical disease by two years or more with a two-week course of teplizumab, according to a phase II study Source: Shutterstock.com (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 3, 2019 Category: Drugs & Pharmacology Source Type: research

Vitamin D not protective against cardiovascular events
Vitamin D supplementation is not associated with a reduced risk of major cardiovascular events, a meta-analysis suggests. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 1, 2019 Category: Drugs & Pharmacology Source Type: research

Alzheimer ’s drug reduces illicit opioid use in methadone recipients
People who take methadone use fewer illicit opioids when galantamine is added to their therapy, research shows. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - July 1, 2019 Category: Drugs & Pharmacology Source Type: research

Prednisolone reduces hand osteoarthritis pain
Patients with hand osteoarthritis experienced improvements in pain and function with low-dose prednisolone treatment, according to a study presented at the European Congress of Rheumatology. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 27, 2019 Category: Drugs & Pharmacology Source Type: research

Creating a coaching culture to support staff wellbeing in an NHS trust
More is being expected of trainee healthcare professionals; clinical educators must enable trainees to feel empowered and encourage them to seek their own solutions, as opposed to professionals telling them what they should do[1]. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 26, 2019 Category: Drugs & Pharmacology Source Type: research

Esketamine nasal spray effective for rapid improvement of depressive symptoms
The ketamine-related nasal spray esketamine is effective at relieving the symptoms of treatment-resistant depression, a phase III study has shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 24, 2019 Category: Drugs & Pharmacology Source Type: research

Weekly contact with pharmacist improves medicine adherence in people with heart failure
Regular consultations with pharmacists lead to improved medicine adherence in people with chronic heart failure (HF), research results show. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 19, 2019 Category: Drugs & Pharmacology Source Type: research

Room for improvement in UK heart failure care, researchers find
National reporting and incentive schemes, such as the Quality and Outcomes Framework, have not prevented suboptimal management of heart failure in the UK, research published in PLoS Medicine has concluded. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Managing osteoporosis in older people
How to understand bone health in the context of the older person, including risk assessment, prevention and the management of osteoporosis in patients likely to have multiple comorbidities. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 12, 2019 Category: Drugs & Pharmacology Source Type: research

Effect of statin on MS progression not related to cholesterol reduction
A previously demonstrated effect of simvastatin in delaying progression of an advanced form of multiple sclerosis is not related to its effect on cholesterol levels, a study published in PNAS has shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 12, 2019 Category: Drugs & Pharmacology Source Type: research

We need a more rational approach to opioid prescribing
The rates of opioid misuse and related deaths may be lower  in the UK than in the United States, but healthcare professionals should remain vigilant when caring for patients with chronic pain. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 11, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetic considerations and challenges in oral anticancer drug therapy
A review of the pros and cons of oral anticancer drug therapy, as well as the pharmacokinetic barriers and potential solutions to oral chemotherapy in the home. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Daily isradipine is ineffective at slowing Parkinson ’s disease
The blood pressure therapy isradipine does not slow disease progression in people with early-stage Parkinson ’s disease, findings presented at the American Academy of Neurology Annual Meeting have shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 31, 2019 Category: Drugs & Pharmacology Source Type: research

Concern over new flushing guidance for small volume intravenous infusions
In November 2018, I raised concerns about incomplete and underdosed intravenous (IV) infusions in Clinical Pharmacist[1]. On this occasion, I am writing to raise concern over the National Infusion and Vascular Access Society ’s (NIVAS’s) new ... (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 30, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacy staff should be aware of drug misusers' methods of extracting opioids from OTC products
Misuse of codeine can cause serious harm. There are restrictions around use of the medicine, but people still find ways to misuse ... (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 28, 2019 Category: Drugs & Pharmacology Source Type: research

Gentamicin not appropriate as first-line treatment for gonorrhoea, researchers say
Gentamicin is no more effective overall than ceftriaxone as a first-line treatment for gonorrhoea but could be a useful alternative for some patients, researchers have said. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 24, 2019 Category: Drugs & Pharmacology Source Type: research

Oral contraceptives protective against ligament injury in young women
Oral contraceptive pills may be protective against anterior cruciate ligament tears in women, particularly in 15 –19 year olds, a study has shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 23, 2019 Category: Drugs & Pharmacology Source Type: research

Cannabis composition alters effects of drug on the brain
Researchers have used functional magnetic resonance imaging  to show how cannabidiol counteracts some of the harmful effects of cannabis on the brain. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 20, 2019 Category: Drugs & Pharmacology Source Type: research

Antibiotics overused in emergency departments for suspected UTI
Over 60% of patients treated for a urinary tract infection lack evidence of the infection, a study carried out in a Birmingham emergency department has found. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 16, 2019 Category: Drugs & Pharmacology Source Type: research

Long-term diuretic use may reduce fracture risk in people with Alzheimer ’s disease
Use of thiazide diuretics for three years or more may reduce the risk of low-energy fracture in people with Alzheimer ’s disease, study results have suggested. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 14, 2019 Category: Drugs & Pharmacology Source Type: research

Antibiotic exposure in middle and late adulthood linked to CVD risk
Women exposed to antibiotics in middle or older adulthood have an increased risk of developing cardiovascular disease, a study published in the European Heart Journal suggests. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 10, 2019 Category: Drugs & Pharmacology Source Type: research

Stevens –Johnson syndrome and toxic epidermal necrolysis
Practical guidelines for the treatment and management of Stevens –Johnson syndrome and toxic epidermal necrolysis, rare but life-threatening conditions that are normally caused by drugs or infections. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 10, 2019 Category: Drugs & Pharmacology Source Type: research

Piloting an undergraduate student-led health check service
There is a growing focus on the development of communication and clinical skills during undergraduate pharmacy programmes; this has been demonstrated particularly by the General Pharmaceutical Council ’s recent consultation on initial education and training (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Patterns of medical cannabis use differ between cancer and non-cancer patients
Patients with cancer who use medical cannabis to treat symptoms, such as pain and neuropathy, tend to favour formulations with a higher ratio of the psychoactive component, tetrahydrocannabinol, compared with non-cancer patients. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Substandard and falsified medicines: global and local efforts to address a growing problem
Substandard and falsified medicines pose a risk to public health all around the world. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 8, 2019 Category: Drugs & Pharmacology Source Type: research

Triple-combination therapy prevents drug resistance in colorectal cancer cells
Treating colorectal cancer  with a trio of targeted drugs reduces the acquisition of drug resistance, in vitro research published in Oncogene shows. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 7, 2019 Category: Drugs & Pharmacology Source Type: research

Reducing cephalosporin-related supply errors
Cephalosporins are a class of beta-lactam antimicrobials that exert bactericidal effects through disruption of the bacterial cell wall. These broad-spectrum antimicrobials have played a core role in the treatment of severe infections since their launch in the latter half of the 20th century. Early generation cephalosporins provide robust coverage of Gram-positive bacteria, while the newer third- and fourth-generations offer additional Gram-negative coverage, including Pseudomonas ... (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

‘One-size-fits-all’ treatment targets harm frail older patients with diabetes
HbA1c targets that ignore differences in the physiology of older patients put them at risk of severe hypoglycaemia, harm and death. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Depression under-recognised in older adults during acute hospital stays
Diagnosis of depression is infrequently recorded on older adults ’ patient notes, a survey of 27 acute hospitals across England has shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - April 18, 2019 Category: Drugs & Pharmacology Source Type: research

Sleeping tablets linked to increased antihypertensive use
Older adults with hypertension who take sleeping tablets are more likely to receive an increased number of antihypertensive medicines over time, study results have shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Painkiller link to childhood asthma unlikely to be causal, researchers say
A previously reported association between analgesic use in pregnancy and childhood asthma is likely to result from confounding factors, researchers have concluded. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Beta interferons improve survival in people with MS
Beta interferons improve survival in patients with relapsing-onset multiple sclerosis when used for at least three years, research has shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - April 12, 2019 Category: Drugs & Pharmacology Source Type: research

Study finds gender differences in reporting adverse drug reactions
Women are more likely to report adverse drug reactions to certain drugs than men, research published in the British Journal of Clinical Pharmacology has shown. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Statins may be linked with type 2 diabetes risk in prospective study
Use of statins may be associated with an increased risk of developing type 2 diabetes, a prospective study has found. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - April 5, 2019 Category: Drugs & Pharmacology Source Type: research

Statins linked with diabetes risk in prospective study
Statin use is associated with an increased risk of developing type 2 diabetes, a prospective study has found. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - April 5, 2019 Category: Drugs & Pharmacology Source Type: research