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Condition: Diabetes Type 1

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Total 127 results found since Jan 2013.

Specific MAPK inhibitors prevent hyperglycemia-induced renal diseases in type 1 diabetic mouse model.
Abstract Mitogen-activated protein kinase (MAPK) and renin-angiotensin system (RAS) play critical roles in the process of renal diseases, but their interaction has not been comprehensively discussed. In the present studies, we investigated the renoprotective effects of MPAK inhibitors on renal diseases in type 1 diabetic mouse model, and clarify the crosstalk among MAPK signaling. Type 1 diabetic mouse model was established in male C57BL/6 J mice, and treated with or without 10 mg/kg MAPK blockers, including ERK inhibitor PD98059, p38 inhibitor SB203850, and JNK inhibitor SP600125 for four weeks. Hyperglycemia i...
Source: Molecular and Cellular Biochemistry - July 6, 2016 Category: Biochemistry Authors: Hong Z, Hong Z, Wu D, Nie H Tags: Mol Cell Biochem Source Type: research

Interferon-alpha inhibits adipogenesis via regulation of JAK/STAT1 signaling
Conclusion We suggest that IFN-α inhibits adipocyte differentiation during the early stage of adipogenesis by regulating the expression of PPARγ and C/EBPα as well as the cell cycle through JAK/STAT1 signaling pathways. General significance Our study provides new insights into possible mechanisms of the anti-adipogenetic effects of IFN-α.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - August 30, 2016 Category: Biochemistry Source Type: research

Atorvastatin Alleviates Experimental Diabetic Cardiomyopathy by Regulating the GSK-3 β-PP2Ac-NF-κB Signaling Axis
by Xiao-min Ren, Guang-feng Zuo, Wen Wu, Jie Luo, Peng Ye, Shao-liang Chen, Zuo-ying Hu Recent studies reported that atorvastatin (ATOR) alleviated progression of experimental diabetic cardiomyopathy (DCM), possibly by protecting against apoptosis. However, the underlying mechanisms of this protective effect remain unclear. Therefore, our study investigated the role of the glycogen s ynthase kinase (GSK)-3β-protein phosphatase 2A(PP2A)-NF-κB signaling pathway in the anti-apoptotic and cardioprotective effects of ATOR on cardiomyocytes cultured in high glucose (HG) and in DCM. Our results showed that, in HG-cultured card...
Source: PLoS One - November 15, 2016 Category: Biomedical Science Authors: Xiao-min Ren Source Type: research

Upregulated serum sclerostin level in the T2DM patients with femur fracture inhibits the expression of bone formation/remodeling-associated biomarkers via antagonizing Wnt signaling.
CONCLUSIONS: Our study demonstrated that the upregulated serum sclerostin level in the T2DM patients with fracture inhibited the expression of the bone formation/remodeling-associated biomarkers via antagonizing Wnt signaling. It suggests that sclerostin might be an effective target for T2DM-associated bone fracture and delayed fracture healing. PMID: 28239825 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - March 1, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22 RESEARCH ARTICLE
ABSTRACT Unique deficits in the function of adult sensory neurons as part of their early neurodegeneration might account for progressive polyneuropathy during chronic diabetes mellitus. Here, we provide structural and functional evidence for aberrant pre-mRNA splicing in a chronic type 1 model of experimental diabetic polyneuropathy (DPN). Cajal bodies (CBs), unique nuclear substructures involved in RNA splicing, increased in number in diabetic sensory neurons, but their expected colocalization with survival motor neuron (SMN) proteins was reduced – a mislocalization described in motor neurons of spinal muscular atro...
Source: DMM Disease Models and Mechanisms - February 28, 2017 Category: Biomedical Science Authors: Kobayashi, M., Chandrasekhar, A., Cheng, C., Martinez, J. A., Ng, H., de la Hoz, C., Zochodne, D. W. Tags: Metabolic Disorders RESEARCH ARTICLE Source Type: research

Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo
Publication date: Available online 5 April 2017 Source:Molecular and Cellular Endocrinology Author(s): Lukas A. Berchtold, Michela Miani, Thi A. Diep, Andreas N. Madsen, Valentina Cigliola, Maikel Colli, Jelena M. Krivokapic, Flemming Pociot, Decio L. Eizirik, Paolo Meda, Birgitte Holst, Nils Billestrup, Joachim Størling Pannexins (Panx's) are membrane proteins involved in a variety of biological processes, including cell death signaling and immune functions. The role and functions of Panx's in pancreatic β-cells remain to be clarified. Here, we show Panx1 and Panx2 expression in isolated islets, primary β-cells, and Î...
Source: Molecular and Cellular Endocrinology - April 6, 2017 Category: Endocrinology Source Type: research

Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo
Publication date: Available online 5 April 2017 Source:Molecular and Cellular Endocrinology Author(s): Lukas A. Berchtold, Michela Miani, Thi A. Diep, Andreas N. Madsen, Valentina Cigliola, Maikel Colli, Jelena M. Krivokapic, Flemming Pociot, Decio L. Eizirik, Paolo Meda, Birgitte Holst, Nils Billestrup, Joachim Størling Pannexins (Panx's) are membrane proteins involved in a variety of biological processes, including cell death signaling and immune functions. The role and functions of Panx's in pancreatic β-cells remain to be clarified. Here, we show Panx1 and Panx2 expression in isolated islets, primary β-cells, and Î...
Source: Molecular and Cellular Endocrinology - April 11, 2017 Category: Endocrinology Source Type: research

Downregulated NLRP3 and NLRP1 inflammasomes signaling pathways in the development and progression of type 1 diabetes mellitus.
CONCLUSION: NLRP3 and NLRP1 inflammasomes signaling pathways were associated with the development and progression of T1DM, which response as protective factors in the early stage of T1DM. PMID: 28783585 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 4, 2017 Category: Drugs & Pharmacology Authors: Liu H, Xu R, Kong Q, Liu J, Yu Z, Zhao C Tags: Biomed Pharmacother Source Type: research

Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats.
Abstract Glycyrrhizic acid (GA) is belonged to triterpenoid saponin that is contained in the root of licorice and is known to affect metabolic regulation. Recently, glucagon like peptide-1 (GLP-1) has widely been applied in diabetes therapeutics. However, the role of GLP-1 in GA-induced anti-diabetic effects is still unknown. Therefore, we are interested in understanding the association of GLP-1 with GA-induced effects. In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), GA increased the level of plasma GLP-1, which was blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 4, 2017 Category: Drugs & Pharmacology Authors: Wang LY, Cheng KC, Li Y, Niu CS, Cheng JT, Niu HS Tags: Biomed Pharmacother Source Type: research

The anti-aging protein Klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells.
Abstract Systemic gamma-aminobutyric acid (GABA) therapy prevents or ameliorates type 1 diabetes (T1D), by suppressing autoimmune responses and stimulating pancreatic beta cells. In beta cells, it increases insulin secretion, prevents apoptosis, and induces regeneration. It is unclear how GABA mediates these effects. We hypothesized that Klotho is involved. It is a multi-functional protein expressed in the kidneys, brain, pancreatic beta cells, other tissues, and is cell-bound or soluble. Klotho knockout mice display accelerated aging, and in humans Klotho circulating levels decline with age, renal disease and dia...
Source: Biochemical and Biophysical Research communications - October 31, 2017 Category: Biochemistry Authors: Prud'homme GJ, Glinka Y, Kurt M, Liu W, Wang Q Tags: Biochem Biophys Res Commun Source Type: research

Investigation of the pronounced erythropoietin-induced reduction in hyperglycemia in type 1-like diabetic rats.
In conclusion, the increased expression of EPOR by hyperglycemia is mainly associated with an augmented expression of nuclear STAT3, which was identified both in vivo and in vitro in the present study. PMID: 29109360 [PubMed - as supplied by publisher]
Source: Endocrine Journal - November 9, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity Metabolism
In conclusion, the relatively low endogenous Spl expression level in insulin-secreting cells contributes to their extraordinary vulnerability to proinflammatory cytokine toxicity and may therefore represent a promising target for β-cell protection in type 1 diabetes mellitus.
Source: Journal of Biological Chemistry - December 8, 2017 Category: Chemistry Authors: Claudine Hahn, Karolina Tyka, Julie D. Saba, Sigurd Lenzen, Ewa Gurgul-Convey Tags: Molecular Bases of Disease Source Type: research

Exploring the role of miRNAs in the diagnosis of MODY3
Conclusion: Although further studies with larger numbers of patients are required, this study demonstrated that the expression levels of miR-200b-3p and miR-378a-5p decrease in MODY3 patients and suggests that miR-200b-3p is an especially strong candidate to use clinically for selecting suspected MODY3 patients. PMID: 29916222 [PubMed]
Source: Turkish Journal of Medical Sciences - June 23, 2018 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes
ConclusionsIn DRG neuron cultures IGF-1 signals via AMPK to elevate mitochondrial function and drive axonal outgrowth. We propose that this signaling axis mediates IGF-1-dependent protection from distal dying-back of fibers in diabetic neuropathy.
Source: Molecular Metabolism - November 29, 2018 Category: Endocrinology Source Type: research

The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes
Conclusions/interpretationSelective loss of STAT6 may contribute to beta cell demise during the progression of type 1 diabetes.
Source: Diabetologia - December 7, 2018 Category: Endocrinology Source Type: research