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Condition: Spinal Cord Injury

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Total 1255 results found since Jan 2013.

Cellular therapy for traumatic neurological injury.
Abstract Neurological injury is the primary lethal mechanism of injury in children, and the primary etiology of long-term disability after trauma. Laboratories and clinical/translational teams have sought to develop stem/progenitor cell therapies to improve recovery in a clinical setting in which there is no significant reparative option. While none of these treatments are currently standard therapeutics, Phase 2b clinical trials are underway in both adults and children in severe traumatic brain injury and Phase 1/2a trials in spinal cord injury. This review will characterize the cell therapy strategies: cell repl...
Source: Pediatric Research - October 6, 2017 Category: Pediatrics Authors: Cox CS Tags: Pediatr Res Source Type: research

Derivatives of Docosahexaenoylethanolamide (DEA) for Neurogenesis
The invention pertains to derivatives of docosahexaenoylethanolamide (synaptamide or DEA) and their use in inducing neurogenesis, neurite growth, and/or synaptogenesis. As such, these DEA derivatives can be used as therapeutics for neurodegenerative diseases such as traumatic brain injury, spinal cord injury, peripheral nerve injury, stroke, multiple sclerosis, autism, Alzheimer ' s disease, Huntington ' s disease, Parkinson ' s disease, amyotrophic lateral sclerosis. The DEA derivatives of the invention have increased potency and hydrolysis resistance as compared to native DEA. Docosahexaenoic acid (DHA), an n-3 polyunsat...
Source: NIH OTT Licensing Opportunities - January 24, 2013 Category: Research Authors: ajoyprabhu3 Source Type: research

Comparison of seating, powered characteristics and functions and costs of electrically powered wheelchairs in a general population of users.
CONCLUSIONS: This is the first large study of a general EPW user population using a seating classification. Significant differences were found between diagnostic groups; nevertheless, there was also high diversity within each group. The differences in provision and the equipment costs across diagnostic groups can be used to improve service planning. Implications for Rehabilitation At a service planning level, knowledge of a population's diagnostic group and age distribution can be used to inform decisions about the number of required EPWs and equipment costs and specialised seating (including review) clinics. At a user lev...
Source: Disability and Rehabilitation. Assistive Technology. - October 26, 2017 Category: Rehabilitation Authors: Dolan MJ, Bolton MJ, Henderson GI Tags: Disabil Rehabil Assist Technol Source Type: research

Current Clinical Applications of Diffusion-Tensor Imaging in Neurological Disorders.
Authors: Tae WS, Ham BJ, Pyun SB, Kang SH, Kim BJ Abstract Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the structure of white matter. The signal contrast in DTI is generated by differences in the Brownian motion of the water molecules in brain tissue. Postprocessed DTI scalars can be used to evaluate changes in the brain tissue caused by disease, disease progression, and treatment responses, which has led to an enormous amount of interest in DTI in clinical research. This review article provides insights into DTI scalars and the biological background of DTI as a relative...
Source: Journal of Clinical Neurology - March 7, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Rehabilitation service models for people with physical and/or mental disability living in low- and middle-income countries: A systematic review.
CONCLUSION: Models of rehabilitation care in inpatient, multidisciplinary and specialized rehabilitation units are recommended for the treatment of severe conditions with recent onset, as they reduce mortality and the need for institutionalized care, especially among elderly patients, stroke patients, or those with chronic back pain. Results are expected to be generalizable for brain/spinal cord injury and complex fractures. PMID: 29616278 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - April 5, 2018 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Quantitative assessment for flexed-elbow deformity during gait following botulinum toxin A treatment
Involuntary flexed-elbow deformity is one of the most common deformities caused by spasticity and a positive sign of upper motor neuron syndrome [1]. In recent years, botulinum toxin A (BoNTA) has been widely used to reduce spasticity in cases of cerebral palsy [2,3], stroke [4 –8], traumatic brain injury [9], and spinal cord injury [10]. A meta-analysis [4] and several randomized controlled trials [5–8] reported the beneficial effects of BoNTA injection for upper-limb spasticity in stroke patients.
Source: Gait and Posture - April 6, 2018 Category: Orthopaedics Authors: Hiroki Tanikawa, Hitoshi Kagaya, Keisuke Inagaki, Yusuke Kotsuji, Keita Suzuki, Kenta Fujimura, Masahiko Mukaino, Satoshi Hirano, Eiichi Saitoh, Yoshikiyo Kanada Tags: Full length article Source Type: research

Urgent Endovascular Treatment for Non-traumatic Descending Thoracic Aortic Rupture
ConclusionEndoluminal repair of non-traumatic rupture of the descending thoracic aorta can be performed percutaneously. It showed a 30-day mortality of 18.1%, and no spinal cord injury or renal complications were observed in surviving patients at follow-up.Level of EvidenceLevel 4, case series.
Source: CardioVascular and Interventional Radiology - July 31, 2018 Category: Radiology Source Type: research

Interview Functional Independence Measure score: self-reporting as a simpler alternative to multidisciplinary functional assessment.
CONCLUSION: There was no FIM assessment for 14 (29.8%) patients, which highlighted the need for alternative assessment tools. Discrepancies in some scores could be due to ignorance among patients about their own limitations or feelings of embarrassment about reporting. Our results may not be valid for patient populations with cognitive or communication deficits. However, a modest agreement between patient self-reporting and multidisciplinary assessment of FIM motor score was demonstrated. Though patients tend to overrate their performance, self-reported FIM motor score could be an alternative in situations where multidisci...
Source: Singapore Medical Journal - September 5, 2018 Category: General Medicine Authors: Vadassery SJ, Kong KH, Ho WML Tags: Singapore Med J Source Type: research

Does acupuncture help patients with spasticity? A narrative review
Publication date: Available online 5 November 2018Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Yi Zhu, Yujie Yang, Jianan LiAbstractSpasticity is a motor disorder encountered after upper motor neuron lesions. It adversely affects quality of life in most patients and causes long-term burden of care and has significant financial implications. The effect of conventional therapies for spasticity including physical therapy, surgery, and pharmacotherapy are not always satisfying because of the short-term effects or side effects in some patients. Acupuncture is a part of traditional medicine originating from C...
Source: Annals of Physical and Rehabilitation Medicine - November 6, 2018 Category: Rehabilitation Source Type: research

Umbilical Cord Blood Mononuclear Cells for Ex-Vivo Gene Therapy
This study was supported by the grant of Russian Science Foundation No 16-15-00010. Kazan Federal University was supported by the Russian Government Program of Competitive Growth.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Bashirov, F. V., Salafutdinov, I. I., Sokolov, M. E., Izmailov, A. A., Markosyan, V. A., Fadeev, F. O., Rizvanov, A., Islamov, R. I. Tags: 801. Gene Therapy and Transfer Source Type: research

Using the natural environment to address the psychosocial impact of neurological disability: A systematic review.
Abstract Engaging with the natural environment contributes to favourable psychosocial health outcomes. A systematic review of research published before June 2017 was conducted to establish how engaging with natural environments impact the psychosocial health of people with a neurological disability. Identified studies included populations with dementia (n=14), brain injury (n=2), and stroke (n=2). Evidence suggests that engaging with gardens, and gardening, can favourably impact the emotional and social health of people with dementia and, an explanatory theoretical model is proposed. Considerable research gaps exi...
Source: Health and Place - December 21, 2018 Category: Environmental Health Authors: Lakhani A, Norwood M, Watling DP, Zeeman H, Kendall E Tags: Health Place Source Type: research

Neural Network Based Modeling and Control of Elbow Joint Motion Under Functional Electrical Stimulation
Publication date: Available online 6 March 2019Source: NeurocomputingAuthor(s): Yurong Li, Wenxin Chen, Jun Chen, Xin Chen, Jie Liang, Min DuAbstractIn patients with stroke and spinal cord injury, motor function is reduced or even lost because motor nerve signals cannot be transmitted due to nerve injury. Functional electrical stimulation (FES) is one of the most important rehabilitation techniques for the treatment of motor impairment in patients with stroke and spinal cord injury, which has been widely used in the recovery and reconstruction of limb motor function. In this paper, we propose a neural network based modelin...
Source: Neurocomputing - March 6, 2019 Category: Neuroscience Source Type: research

Review of the Current Knowledge on the Role of Stem Cell Transplantation in Neurorehabilitation.
Abstract The management involving stem cell (SC) therapy along with physiotherapy offers tremendous chance for patients after spinal cord injury (SCI), traumatic brain injury (TBI), stroke, etc. However, there are still only a limited number of reports assessing the impact of stem cells (SCs) on the rehabilitation process and/or the results of the simultaneous use of SC and rehabilitation. Additionally, since there is still not enough convincing evidence about the effect of SCT on humans, e.g., in stroke, there have been no studies conducted concerning rehabilitation program formation and expected outcomes. It has...
Source: Biomed Res - April 3, 2019 Category: Research Authors: Kamelska-Sadowska AM, Wojtkiewicz J, Kowalski IM Tags: Biomed Res Int Source Type: research

Intravenous Infusion of Mesenchymal Stem Cells Improves Impaired Cognitive Function in a Cerebral Small Vessel Disease Model
Publication date: Available online 16 April 2019Source: NeuroscienceAuthor(s): Masahito Nakazaki, Masanori Sasaki, Yuko Kataoka-Sasaki, Shinichi Oka, Junpei Suzuki, Yuichi Sasaki, Hiroshi Nagahama, Kazuo Hashi, Jeffery D. Kocsis, Osamu HonmouAbstractCerebral small vessel disease (CSVD) is not only a cause of vascular dementia (VD) but also a contributing factor to Alzheimer's disease (AD). The essential pathological feature of CSVD is the disruption of blood–brain barrier (BBB). Dysfunction of BBB due to degeneration of both endothelial cells and pericytes in capillaries leads to neuronal damage and progressive brain atr...
Source: Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research

Respiratory muscle training in athletes with cervical spinal cord injury: effects on cardiopulmonary function and exercise capacity.
This article is protected by copyright. All rights reserved. PMID: 31115056 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - May 20, 2019 Category: Physiology Authors: Gee CM, Williams AM, Sheel AW, Eves ND, West CR Tags: J Physiol Source Type: research