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Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study
CONCLUSIONS: Certain embolic sources and uncommon causes may be etiologically important causes of ischemic stroke in young adults. However, the contribution of conventional vascular risk factors and lifestyle-related risk factors is not negligible with advancing age, even in young adults.PMID:35830430 | DOI:10.1371/journal.pone.0268481
Source: Atherosclerosis - July 13, 2022 Category: Cardiology Authors: Yuichiro Ohya Ryu Matsuo Noriko Sato Fumi Irie Kuniyuki Nakamura Yoshinobu Wakisaka Tetsuro Ago Masahiro Kamouchi Takanari Kitazono Investigators for Fukuoka Stroke Registry Source Type: research

Cardio-embolic stroke: Lessons from a single centre in Sub-Saharan Africa.
CONCLUSION: CES accounted for 1/4 of ischemic stroke with a high risk of early death and long-term recurrence. Atrial fibrillation was the leading cause of CES. The association of VKA and anti-platelet agent should be avoided to reduce early death during acute stroke. PMID: 31155304 [PubMed - as supplied by publisher]
Source: Revue Neurologique - June 4, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

The contribution of systematic implementation of cardiovascular explorations for the detection of cardiac sources of embolism in patients with stroke: About 230  patients.
CONCLUSION: Cardiovascular explorations remain indispensable in the workup of all ischemic strokes even if their therapeutic effect is modest. The lacunar infarct out first at 34% followed by 32% of cardio embolic causes and atheroma of the neck vessels in approximately 16%. PMID: 29753425 [PubMed - as supplied by publisher]
Source: Annales de Cardiologie et d'Angeiologie - May 9, 2018 Category: Cardiology Authors: Hadi A, Bendriss L, Khatouri A Tags: Ann Cardiol Angeiol (Paris) Source Type: research

Cardioembolic stroke and cardiomyopathy: Rhythm is the key
Cardiomyopathy (CM) predisposes patients to cardioembolism. Stroke and peripheral embolization occur at an annual incidence rate of 0.8% in hypertrophic cardiomyopathy (HCM) [1]. Embolic events have an incidence rate ranging from 1.5 to 3.5 per 100 patient-years in dilated cardiomyopathy (DCM) [2]. However, few studies have described the clinical profile of ischemic stroke associated with CM.
Source: Journal of the Neurological Sciences - July 24, 2017 Category: Neurology Authors: Li Chung Hin, Ma Sin Kwan Tammy, Chang Richard Shek-Kwan Tags: Letter to the Editor Source Type: research

RNA sequencing uncover crucial genes mediating progression of large-artery atherosclerotic and small-artery occlusion ischemic stroke
CONCLUSION: This finding may help to understand the mechanisms of LAAIS and SAOIS and offer novel clues for finding specific biomarkers for LAAIS and SAOIS.PMID:36096198 | DOI:10.1016/j.brainres.2022.148078
Source: Brain Research - September 12, 2022 Category: Neurology Authors: Zhaolin Chen Duncai Wei Xiaopu Chen Yinting Huang Zibin Shen Wenzhen He Source Type: research

Perioperative changes of the slope in the preload recruitable stroke work relationship by a single-beat technique after mitral valve surgery in functional mitral regurgitation with non-ischemic dilated cardiomyopathy
ConclusionsThe change of slope was dependent on surgical procedures. In functional mitral regurgitation, the slope may be a more sensitive parameter in reflecting the left ventricular contractile function than the left ventricular ejection fraction.
Source: General Thoracic and Cardiovascular Surgery - June 21, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Cardiac Preload Responsiveness in Children With Cardiovascular Dysfunction or Dilated Cardiomyopathy: A Multicenter Observational Study*
Conclusions: This study provides “normal” values for global end-diastolic volume index and limits of cardiac preload responsiveness in pediatric patients with cardiovascular dysfunction and dilated cardiomyopathy: 1.33 times normal global end-diastolic volume index represents the upper limit of patent cardiac preload responsiveness, with the highest expected responsiveness being below 0.67 times normal global end-diastolic volume index. The maximum response of the Frank-Starling relationship and therefore the level of no additional preload reserve is 1.33 to 1.51 times normal global end-diastolic volume index. Above 1....
Source: Pediatric Critical Care Medicine - January 1, 2015 Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

Anticoagulation versus placebo for heart failure in sinus rhythm
CONCLUSIONS: Based on the three RCTs, there is no evidence that oral anticoagulant therapy modifies mortality in people with HF in sinus rhythm. The evidence is uncertain if warfarin has any effect on all-cause death compared to placebo or no treatment, but it may increase the risk of major bleeding events. There is no evidence of a difference in the effect of rivaroxaban on all-cause death compared to placebo. It probably reduces the risk of stroke, but probably increases the risk of major bleedings. The available evidence does not support the routine use of anticoagulation in people with HF who remain in sinus rhythm.PMI...
Source: Cochrane Database of Systematic Reviews - May 18, 2021 Category: General Medicine Authors: Eduard Shantsila Monika Kozie ł Gregory Yh Lip Source Type: research

A review of the epidemiology of atrial fibrillation in Sub ‐Saharan Africa
In conclusion, AF seems to have a higher prevalence in the general population than previously thought, and is mostly associa ted with hypertension, cardiomyopathy and rheumatic heart disease in SSA. It is associated with a high incidence of heart failure and stroke. The management of AF is suboptimal in SSA, especially with a low uptake of oral anticoagulation.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - October 8, 2019 Category: Cardiology Authors: Jean Jacques Noubiap, Ulrich Flore Nyaga Tags: COMPREHENSIVE REVIEWS Source Type: research

Low-dose dobutamine induces left ventricular mechanical dyssynchrony in patients with dilated cardiomyopathy and a narrow QRS: a study using real-time three-dimensional echocardiography.
CONCLUSIONS: Dobutamine may induce LV mechanical dyssynchrony in a substantial proportion of patients with DCM and a narrow QRS. In such cases, regional LV contractile reserve does not fully contribute to an increase in global LVSV. PMID: 23473770 [PubMed - in process]
Source: Journal of Cardiology - April 1, 2013 Category: Cardiology Authors: Yagishita-Tagawa Y, Abe Y, Arai K, Yagishita D, Takagi A, Ashihara K, Shoda M, Naruko T, Itoh A, Haze K, Yoshikawa J, Hagiwara N Tags: J Cardiol Source Type: research

Age-Dependence of Flow Homeostasis in the Left Ventricle
Conclusions: In average, blood spends 1 to 3 beats inside the LV with very low shear stress rates. The apical region is the most prone to blood stasis, particularly in mid-aged adults. The washout of blood in the normal LV is age-dependent due to physiological changes in the degree of apical penetration of the filling waves. Introduction Cardioembolic stroke is a major source of mortality and disability worldwide and blood stasis one of its major determinants (Adams et al., 1986). Left ventricular (LV) function has evolved to maximize mechanical efficiency and ensure organ perfusion at a low cost of energy and fill...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Anticoagulation versus placebo for heart failure in sinus rhythm.
CONCLUSIONS: Based on the two major randomised trials (HELAS 2006; WASH 2004), there is no convincing evidence that oral anticoagulant therapy modifies mortality or vascular events in patients with heart failure and sinus rhythm. Although oral anticoagulation is indicated in certain groups of patients with heart failure (for example those with atrial fibrillation), the available data does not support the routine use of anticoagulation in heart failure patients who remain in sinus rhythm. PMID: 24683002 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - March 28, 2014 Category: Journals (General) Authors: Lip GY, Shantsila E Tags: Cochrane Database Syst Rev Source Type: research

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