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Cancer: Neuroblastoma

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Total 288 results found since Jan 2013.

Mechanistic study of mtROS-JNK-SOD2 signaling in bupivacaine-induced neuron oxidative stress.
Abstract Manganese superoxide dismutase (SOD2) is a key enzyme to scavenge free radical superoxide in the mitochondrion. SOD2 deficiency leads to oxidative injury in cells. Bupivacaine, a local anesthetic commonly used in clinic, could induce neurotoxic injury via oxidative stress. The role and the mechanism of SOD2 regulation in bupivacaine-induced oxidative stress remains unclear. Here, bupivacaine was used to treat Sprague-Dawley rats with intrathecal injection and culture human neuroblastoma cells for developing vivo injury model and vitro injury model. The results showed that bupivacaine caused the over-produ...
Source: Aging - July 12, 2020 Category: Biomedical Science Authors: Liu Z, Xu S, Ji Z, Xu H, Zhao W, Xia Z, Xu R Tags: Aging (Albany NY) Source Type: research

Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells.
This study provides information about a possible interaction of Speedy/RINGO with PI3K/AKT and ERK/MAPK pathways in SH-SY5Y cells for the first time. It will not only help to better understand the cancer-prone interactions of these pathways but also enable us to identify the appropriate molecular targets for developing efficient treatment strategies. PMID: 32602013 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - June 28, 2020 Category: Biochemistry Authors: Kaya Y, Kucukvardar S, Yildiz A Tags: Mol Cell Biochem Source Type: research

Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma
In this study we validate the histone methyltransferase G9a/EHMT2 as being associated with indicators of poor prognosis in NB. Immunological analysis of G9a protein shows it to be more highly expressed in NB cell-lines with MYCN amplification, which is a primary determinant of dismal outcome in NB patients. Furthermore, G9a protein in primary tumors is expressed at higher levels in poorly differentiated/undifferentiated NB, and correlates with high EZH2 expression, a known co-operative oncoprotein in NB. Our functional analyses demonstrate that siRNA-mediated G9a depletion inhibits cell growth in all NB cell lines, but, st...
Source: Frontiers in Oncology - May 26, 2020 Category: Cancer & Oncology Source Type: research

LRP6 mediated signal transduction pathway triggered by tissue plasminogen activator acts through lipid rafts in neuroblastoma cells.
Abstract LDL receptor-related proteins 6 (LRP6) is a type I transmembrane receptor (C-terminus in cytosol), which appears to be essential in numerous biological processes, since it is an essential co-receptor of Wnt ligands for canonical β-catenin dependent signal transduction. It was shown that tissue plasminogen activator (tPA), physically interacting with LRP6, induces protein phosphorylation, which may have large implication in the regulation of neural processes. In this investigation we analyzed whether LRP6 is associated with lipid rafts following tPA triggering in neuroblastoma cells and the role of raft i...
Source: Journal of Cell Communication and Signaling - February 14, 2020 Category: Molecular Biology Authors: Riitano G, Manganelli V, Capozzi A, Mattei V, Recalchi S, Martellucci S, Longo A, Misasi R, Garofalo T, Sorice M Tags: J Cell Commun Signal Source Type: research

NEAT1 Negatively Regulates Cell Proliferation and Migration of Neuroblastoma Cells by miR-183-5p/FOXP1 Via the ERK/AKT Pathway.
Abstract Neuroblastoma, a malignant tumor of the sympathetic nervous system, is an aggressive extracranial tumor in childhood. Long noncoding RNAs (lncRNAs) have been discovered to play a key role in the eukaryotic regulatory gene network and be involved in a wide variety of biological processes. We observed that the expression of lncRNA nuclear-enriched abundant transcript-1 (NEAT1) was significantly decreased in human neuroblastoma tissues and cell lines, compared with the normal. We observed cell proliferation, migration, and invasion with Cell Counting Kit-8 assay, colony formation assay, and Transwell assay t...
Source: Cell Transplantation - December 31, 2019 Category: Cytology Authors: Pan W, Wu A, Yu H, Yu Q, Zheng B, Yang W, Tian D, Gao Y, Li P Tags: Cell Transplant Source Type: research

Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin {beta} Molecular Bases of Disease
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by abnormal deposition of β-amyloid (Aβ) peptides. Aβ is a cleavage product of the amyloid precursor protein (APP), and aberrant posttranslational modifications of APP can alter APP processing and increase Aβ generation. In the AD brain, seven different residues, including Ser-675 (APP695 numbering) in the APP cytoplasmic domain has been found to be phosphorylated. Here, we show that expression of a phosphomimetic variant of Ser-675 in APP (APP-S675E), in human neuroblastoma SK-N-AS cells, reduces secretion of the soluble APP ectodomain (sAPPα), ev...
Source: Journal of Biological Chemistry - November 21, 2019 Category: Chemistry Authors: Preeti Kumaran Menon, Niina Anneli Koistinen, Kerstin Iverfeldt, Anna–Lena Strom Tags: Neurobiology Source Type: research

Beneficial effects of PGC-1 α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity.
CONCLUSIONS: Our results indicated that PGC-1α rescues the effects of MPTP-induced mitochondrial dysfunction in C57BL mice. PMID: 31634150 [PubMed - as supplied by publisher]
Source: Aging - October 20, 2019 Category: Biomedical Science Authors: Wang Y, Chen C, Huang W, Huang M, Wang J, Chen X, Ye Q Tags: Aging (Albany NY) Source Type: research

Downregulation of microRNA-3934-5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1.
Authors: Ye W, Liang F, Ying C, Zhang M, Feng D, Jiang X Abstract Neuroblastoma is the most common pediatric extracranial solid tumour in the world. miRNAs are a group of endogenous small non-coding RNAs that act on target genes to serve critical roles in many biological processes. Presently, the expression and role of miR-3934-5p in neuroblastoma remains unclear. Therefore, the aim of the present study was to investigate the expression of miR-3934-5p in neuroblastoma tissues and cell lines and to assess the role of miR-3934-5p in neuroblastoma. In the current study, the results revealed that miR-3934-5p was signif...
Source: Experimental and Therapeutic Medicine - October 18, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

A multimolecular signaling complex including PrPC and LRP1 is strictly dependent on lipid rafts and is essential for the function of tissue Plasminogen Activator
AbstractPrion protein (PrPC) localizes stably in lipid rafts microdomains and is able to recruit downstream signal transduction pathways by the interaction with promiscuous partners. Other proteins have the ability to occasionally be recruited to these specialized membrane areas, within multimolecular complexes. Among these, we highlight the presence of the low ‐density lipoprotein receptor related protein 1 (LRP1), which was found localize transiently in lipid rafts, suggesting a different function of this receptor that through lipid raft becomes able to activate a signal transduction pathway triggered by specific ligan...
Source: Journal of Neurochemistry - October 10, 2019 Category: Neuroscience Authors: Vincenzo Mattei, Valeria Manganelli, Stefano Martellucci, Antonella Capozzi, Elisabetta Mantuano, Agostina Longo, Alberto Ferri, Tina Garofalo, Maurizio Sorice, Roberta Misasi Tags: ORIGINAL ARTICLE Source Type: research

Nitrendipine, an antihypertensive alpha calcium channel blocker, is cytotoxic to neuroblastoma cells
ConclusionNTD induced apoptosis on neuroblastoma cells, appears to be independent of the expression of the L-type calcium channel.
Source: Molecular and Cellular Toxicology - September 30, 2019 Category: Cytology Source Type: research

Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of {beta}-arrestin2 Signal Transduction
Acute alcohol exposure alters the trafficking and function of many G-protein–coupled receptors (GPCRs) that are associated with aberrant behavioral responses to alcohol. However, the molecular mechanisms underlying alcohol-induced changes in GPCR function remain unclear. β-Arrestin is a key player involved in the regulation of GPCR internalization and thus controls the magnitude and duration of GPCR signaling. Although β-arrestin levels are influenced by various drugs of abuse, the effect of alcohol exposure on β-arrestin expression and β-arrestin–mediated GPCR trafficking is poorly understood. Here, we found that ...
Source: Journal of Biological Chemistry - September 19, 2019 Category: Chemistry Authors: Deborah J. Luessen, Haiguo Sun, Molly M. McGinnis, Michael Hagstrom, Glen Marrs, Brian A. McCool, Rong Chen Tags: Neurobiology Source Type: research

Cerebellar Fastigial Nucleus Stimulation in a Chronic Unpredictable Mild Stress Rat Model Reduces Post-Stroke Depression by Suppressing Brain Inflammation via the microRNA-29c/TNFRSF1A Signaling Pathway.
CONCLUSIONS In a rat model, cerebellar fastigial nucleus stimulation reduced the expression of TNFRSF1A by upregulating miR-29c expression, which suppressed the expression of inflammatory cytokines, resulting in reduced severity of post-stroke depression. PMID: 31352465 [PubMed - in process]
Source: Medical Science Monitor - July 30, 2019 Category: Research Tags: Med Sci Monit Source Type: research

miR-34a inhibits proliferation, migration and invasion of paediatric neuroblastoma cells via targeting HNF4 α.
Conclusion: The expression of miR-34a was down-regulated in paediatric neuroblastoma tissues, and overexpression of miR-34a could inhibit proliferation, migration and invasion of SH-SY5Y cells by targeting HNF4α. PMID: 31343368 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - July 27, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Eclalbasaponin I causes mitophagy to repress oxidative stress-induced apoptosis via activation of p38 and ERK in SH-SY5Y cells.
In this study, pretreatment with EcI in SH-SY5Y cells significantly activated the p38-mitogenactivated protein kinase (p38), the extracellular regulated protein kinase (ERK), whereas it did not affect the c-jun NH2 terminal kinases (JNK). In accordance with the initial findings, EcI-induced neuroprotective effect was attenuated by SB203580 (SB, a p38 inhibitor) or FR180204 (FR, an ERK inhibitor), being further confirmed by specific small interfering RNA (siRNA). Inhibition of either p38 or ERK up-regulated the apoptosis induction in EcI- and H2O2-cotreated cells. Furthermore, p38 or ERK suppression enhanced intracellular a...
Source: Free Radical Research - June 14, 2019 Category: Research Tags: Free Radic Res Source Type: research

Regulatory Role of lncRNA NONHSAT089447 in the Dopamine Signaling Pathway in Schizophrenic Patients.
CONCLUSIONS Our results revealed that the lncRNA NONHSAT089447 participated in the dopamine signaling pathway via upregulation of DRDs. PMID: 31180069 [PubMed - in process]
Source: Medical Science Monitor - June 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research