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Cancer: Neuroblastoma
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Total 288 results found since Jan 2013.
Dihydropyrimidinase‐like protein 3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastoma
Dihydropyrimidinase‐like proteins (DPYSLs) are a family of proteins developmentally regulated during maturation of the nervous system. Recently, members of the DPYSL family have been reported to be involved in cancer with low expression of DPYSL1 correlating with poor clinical outcomes in non‐small cell lung cancer and functioning as a metastasis suppressor. Neuroblastoma (NB) is a tumor derived from precursor cells of the sympathetic nervous system and is the most common solid tumor in childhood. So far the biological functions of DPYSLs in NB remain elusive. Studying the potential roles of DPYSLs in NB may give us ne...
Source: Cancer Science - October 20, 2013 Category: Cancer & Oncology Authors: Fei Tan, Reema Wahdan‐Alaswad, Shuang Yan, Carol J. Thiele, Zhijie Li Tags: Original Article Source Type: research
Trichostatin A epigenetically increases calpastatin expression, and inhibits calpain activity and calcium‐induced SH‐SY5Y neuronal cell toxicity
This study demonstrates that TSA attenuates calcium‐induced neuronal cell death by the inhibition of calpain activity which is mediated in part by increased calpastatin expression via histone hyperacetylation within calpastatin promoter region. Our study provides a novel mechanism for the neuroprotective effect of HDAC inhibitors on AD.
This article is protected by copyright. All rights reserved.
Source: FEBS Journal - October 18, 2013 Category: Research Authors: Jungwon Seo, Sangmee Ahn Jo, Soojin Hwang, Catherine Jeonghae Byun, Hyeon‐Ju Lee, Du‐Hyong Cho, Dueon Kim, Young Ho Koh, Inho Jo Tags: Original Article Source Type: research
Comparative toxicogenomic responses of mercuric and methyl-mercury
Conclusions:
These results suggest that, contrary to previous reports, inorganic and organic mercurials have different mechanisms of toxicity. The two mercurials induced disparate effects on gene expression, and different genes were important in protecting the organism from mercurial toxicity.
Source: BMC Genomics - Latest articles - October 11, 2013 Category: Genetics & Stem Cells Authors: Matthew McElweeLindsey HoJeff ChouMarjolein SmithJonathan Freedman Source Type: research
Involvement of midkine in neuroblastoma tumorigenesis
Summary
Midkine is highly expressed in various cancers, including neuroblastoma, one of the most malignant pediatric solid tumors, and it has been shown to be useful as a tumor marker, a prognosis factor, and a target of molecular therapy. In order to establish a midkine‐targetting therapy, several molecular tools (e.g., siRNA, antibodies, and RNA aptamer) have been used. In neuroblastoma, the involvement of midkine in tumorigenesis has been revealed in vivo by model mice, and its targetting by RNA aptamer has been shown to be effective toward xenografted tumors. Chemoresistance is one of the notable phenotypes regulated...
Source: British Journal of Pharmacology - October 7, 2013 Category: Drugs & Pharmacology Authors: S Kishida, K Kadomatsu Tags: Review Article – Midkine Themed Issue Source Type: research
DPYSL3 expression is negatively regulated by MYCN and associated with clinical outcome in neuroblastoma
This article is protected by copyright. All rights reserved.
Source: Cancer Science - September 6, 2013 Category: Cancer & Oncology Authors: Fei Tan, Reema Wahdan‐Alaswad, Shuang Yan, Carol J. Thiele, Zhijie Li Tags: Original Article Source Type: research
Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells.
Abstract
The cysteine carboxypeptidase cathepsin X is an important player in degenerative processes under normal aging and pathological conditions. In the present study, we investigated the potential role of cathepsin X in 6-hydroxydopamine (6-OHDA)-induced toxicity in the pheochromocytoma cell line PC12 and neuroblastoma cell line SH-SY5Y. Cells exposed to 6-OHDA demonstrated alterations in the protein level of cathepsin X and activity of cathepsin X. Downregulation of cathepsin X expression by siRNA attenuated the neuronal death caused by 6-OHDA. Treatment with specific cathepsin X inhibitor AMS36 protected cell...
Source: Neuropharmacology - August 16, 2013 Category: Drugs & Pharmacology Authors: Pišlar AH, Zidar N, Kikelj D, Kos J Tags: Neuropharmacology Source Type: research
NBPF is a potential DNA-binding transcription factor that is directly regulated by NF-κB.
In this study, the genes of NBPF family were found to be densely covered by many high-confidence ChIP-Seq peaks of NF-κB. The expressions of NBPF genes were thus deduced to be regulated by this transcription factor. The activities of NF-κB in HeLa, HepG2 and ECa109 cells were then manipulated with NF-κB activator (TNFα) and inhibitors (BAY11-7082 or p65 siRNA), and the expressions of NBPF genes in these cells were checked. As result, it was found that the expressions of NBPF genes were regulated by NF-κB in HeLa and HepG2 cells. Therefore, the genes of NBPF family were identified as new bona fide direct target genes o...
Source: The International Journal of Biochemistry and Cell Biology - August 9, 2013 Category: Biochemistry Authors: Zhou F, Xing Y, Xu X, Yang Y, Zhang J, Ma Z, Wang J Tags: Int J Biochem Cell Biol Source Type: research
Integrin β1 is critical for gastrin-releasing peptide receptor-mediated neuroblastoma cell migration and invasion
Conclusion: GRP/GRP-R signaling contributes to neuroblastoma cell migration and invasion. Moreover, the integrin ß1 subunit critically regulates GRP-R–mediated neuroblastoma cell migration and invasion.
Source: Surgery - August 1, 2013 Category: Surgery Authors: Sora Lee, Jingbo Qiao, Pritha Paul, Dai H. Chung Tags: Society of University Surgeons Source Type: research
Target delivery of MYCN siRNA by folate-nanoliposomes delivery system in a metastatic neuroblastoma model
In this study, we established a bone marrow and bone metastasis xenograft mouse model by injecting the LA-N-5 cell into the bone marrow cavity. Fluorescence microscopy, TUNEL Assay, Quantitative RT-PCR and western blot were conducted to analysis the distribution of folate-nanoliposomes entrapped MYCN (V-myc myelocytomatosis viral related oncogene) siRNA in mice and the relevant suppression effect.
Results:
The folate-nanoliposomes entrapped MYCN siRNA can be specifically distributed in tumor tissues. Further study shows that folate-nanoliposomes entrapped MYCN siRNA lead to MYCN mRNA expression significantly down-regulated (>50%, and p
Source: Cancer Cell International - June 27, 2013 Category: Cancer & Oncology Authors: Qiqi ZhuChen FengWeiwei LiaoYan ZhangSuoqin Tang Source Type: research
Amlodipine prevents apoptotic cell death by correction of elevated intracellular calcium in a primary neuronal model of Batten disease (CLN3 disease).
Abstract
CLN3 disease (Spielmeyer-Vogt-Sjogren-Batten disease) is a severe pediatric neurodegenerative disorder for which there is currently no effective treatment. The disease is characterized by progressive neuronal death, which may be triggered by abnormal intracellular calcium levels leading to neuronal apoptosis. Previously, we demonstrated reversal of the calcium effect in a neuroblastoma cell line using amlodipine and other calcium channel antagonists. In the present studies, we developed a CLN3 siRNA-inhibited primary rat neuron model to further study etoposide-induced calcium changes and apoptosis in CLN3...
Source: Biochemical and Biophysical Research communications - June 12, 2013 Category: Biochemistry Authors: Warnock A, Tan L, Li C, Haack KA, Narayan SB, Bennett MJ Tags: Biochem Biophys Res Commun Source Type: research
Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells.
Abstract
Neuroblastoma is one of the most common extracranial solid cancers found in young children. The prognosis of neuroblastoma patients in advanced stages having N-myc amplification remains poor despite intensive multimodal therapy. Agents that trigger neuroblastoma cells to undergo cellular differentiation and thereby stop proliferation have attracted considerable interest as an alternative therapy. Tryptanthrin (12-dihydro-6,12-dioxoindolo-(2,1-b)-quinazoline) is a weakly basic alkaloid isolated from the dried roots of medicinal indigo plants known as Banlangen. It has been shown to possess various biologic...
Source: Chemico-Biological Interactions - April 25, 2013 Category: Molecular Biology Authors: Liao X, Leung KN Tags: Chem Biol Interact Source Type: research
Autophagy Alleviates Neurodegeneration Caused by Mild Impairment of Oxidative Metabolism
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - April 15, 2013 Category: Neurology Authors: Ya Meng, Yue Yong, Guang Yang, Hanqing Ding, Zhiqin Fan, Yifen Tang, Jia Luo, Zun‐Ji Ke Tags: Original Article Source Type: research
Toll-like receptor 3 expression inhibits cell invasion and migration and predicts a favorable prognosis in neuroblastoma
Highlights: Abstract: To evaluate the clinical significance of TLR3 expression on neuroblastomas, we performed immunohistochemical study on archival tissues and in vitro studies on neuroblastoma cell lines. The results showed that positive TLR3 expression was associated with favorable histology and prognosis. Activation of TLR3 by polyinosinic:polycytidylic acid [poly(I:C)] treatment is effective to suppress cell migration and invasion and to decrease organized assembly of F-actin and filopodia formation, in TLR3-expressing SK-N-AS cells, which could be reversed by TLR3-targeting siRNA treatment. TLR3 agonist poly(I:C) pro...
Source: Cancer Letters - April 15, 2013 Category: Cancer & Oncology Authors: Wen-Ming Hsu, Chao-Cheng Huang, Pei-Yi Wu, Hsinyu Lee, Min-Chuan Huang, Ming-Hong Tai, Jiin-Haur Chuang Tags: Research Articles Source Type: research
Expressional alterations in functional ultra-conserved non-coding RNAs in response to all-trans retinoic acid - induced differentiation in neuroblastoma cells
Conclusions:
Our results indicate that significant numbers of T-UCRs have altered expression levels in response to ATRA. While the precise roles that T-UCRs might play in cancer or in normal development are largely unknown and an important area for future study, our findings strongly indicate that the function of non-coding RNA T-UC.300A is connected with proliferation, invasion and the inhibition of differentiation of neuroblastoma cell lines prior to ATRA treatment.
Source: BMC Cancer - April 8, 2013 Category: Cancer & Oncology Authors: Karen WattersKenneth BryanNiamh FoleyMaria MeehanRaymond Stallings Source Type: research
MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1
Conclusion:
Our study’s results are consistent with miR-497 being a candidate tumor suppressor in neuroblastoma, through the direct targeting of WEE1. These findings re-enforce the proposal of WEE1 as a therapeutic target in neuroblastoma.
Source: Molecular Cancer - March 26, 2013 Category: Cancer & Oncology Authors: Laura CreeveyJacqueline RyanHarry HarveyIsabella BrayMaria MeehanAdnan KhanRaymond Stallings Source Type: research
