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Cancer: Neuroblastoma

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Total 288 results found since Jan 2013.

miR‐542‐3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin
Abstract MicroRNAs (miRNAs) are deregulated in a variety of human cancers, including neuroblastoma, the most common extracranial tumor of childhood. We previously reported a signature of 42 miRNAs to be highly predictive of neuroblastoma outcome. One miRNA in this signature, miR‐542, was downregulated in tumors from patients with adverse outcome. Re‐analysis of quantitative PCR and next‐generation sequencing transcript data revealed that miR‐542‐5p as well as miR‐542‐3p expression is inversely correlated with poor prognosis in neuroblastoma patients. We, therefore, analyzed the function of miR‐542 in neurob...
Source: International Journal of Cancer - July 21, 2014 Category: Cancer & Oncology Authors: Kristina Althoff, Sven Lindner, Andrea Odersky, Pieter Mestdagh, Anneleen Beckers, Sarah Karczewski, Jan J. Molenaar, Anna Bohrer, Shirley Knauer, Frank Speleman, Matthias Epple, Diana Kozlova, Sena Yoon, Kwanghee Baek, Jo Vandesompele, Angelika Eggert, A Tags: Cancer Cell Biology Source Type: research

Dual blockade of the A1 and A2A adenosine receptor prevents amyloid beta toxicity in neuroblastoma cells exposed to aluminum chloride.
Abstract In a previous work we have shown that exposure to aluminum (Al) chloride (AlCl3) enhanced the neurotoxicity of the amyloid beta25-35 fragment (Abeta25-35) in neuroblastoma cells and affected the expression of Alzheimer's disease (AD)-related genes. Caffein, a compound endowed with beneficial effects against AD, exerts neuroprotection primarily through its antagonist activity on A2A adenosine receptors (A2AR), although it also inhibits A1Rs with similar potency. Still, studies on the specific involvement of these receptors in neuroprotection in a model of combined neurotoxicity (Abeta25-35+AlCl3) are missi...
Source: The International Journal of Biochemistry and Cell Biology - July 21, 2014 Category: Biochemistry Authors: Giunta S, Andriolo V, Castorina A Tags: Int J Biochem Cell Biol Source Type: research

Downregulation of survivin by siRNA inhibits invasion and promotes apoptosis in neuroblastoma SH-SY5Y cells.
Abstract Neuroblastoma is a solid tumor that occurs mainly in children. Malignant neuroblastomas have a poor prognosis because conventional chemotherapeutic agents are not very effective. Survivin, a member of the inhibitor of the apoptosis protein family, plays a significant role in cell division, inhibition of apoptosis, and promotion of cell proliferation and invasion. Previous studies found that survivin is highly expressed in some malignant neuroblastomas and is correlated with poor prognosis. The aim of this study was to investigate whether survivin could serve as a potential therapeutic target of human neur...
Source: Braz J Med Biol Res - May 23, 2014 Category: Research Authors: Zhang L, Liang H, Cao W, Xu R, Ju XL Tags: Braz J Med Biol Res Source Type: research

Protective effect of the thioredoxin and glutaredoxin systems in dopamine induced cell death.
In conclusion, our results suggest that the two redox systems are important for neuronal survival in dopamine induced cell death. PMID: 24863694 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - May 23, 2014 Category: Biology Authors: Arodin L, Miranda-Vizuete A, Swoboda P, Fernandes AP Tags: Free Radic Biol Med Source Type: research

Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma
Conclusions: Taken together, our data for the first time demonstrate that S1P induced the macrophage-recruiting factor CCL2 expression in NB cells via S1P2, providing new insights into the complicated functions of S1P2 in cancer.
Source: Journal of Pediatric Surgery - May 19, 2014 Category: Surgery Authors: Mei-Hong Li, Miriam Harel, Timothy Hla, Fernando Ferrer Tags: Original Articles Source Type: research

Autophagy Is Modulated in Human Neuroblastoma Cells Through Direct Exposition to Low Frequency Electromagnetic Fields
In neurogenerative diseases, comprising Alzheimer's (AD), functional alteration in autophagy is considered one of the pathological hallmarks and a promising therapeutic target. Epidemiological investigations on the possible causes undergoing these diseases have suggested that electromagnetic fields (EMF) exposition can contribute to their etiology. On the other hand, EMF have therapeutic implications in reactivating neuronal functionality. To partly clarify this dualism, the effect of low‐frequency EMF (LF‐EMF) on the modulation of autophagy was investigated in human neuroblastoma SH‐SY5Y cells, which were also subse...
Source: Journal of Cellular Physiology - March 27, 2014 Category: Cytology Authors: Nicoletta Marchesi, Cecilia Osera, Lorenzo Fassina, Marialaura Amadio, Francesca Angeletti, Martina Morini, Giovanni Magenes, Letizia Venturini, Marco Biggiogera, Giovanni Ricevuti, Stefano Govoni, Salvatore Caorsi, Alessia Pascale, Sergio Comincini Tags: Original Research Article Source Type: research

Involvement of midkine in neuroblastoma tumourigenesis
This article is part of a themed section on Midkine. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue‐4
Source: British Journal of Pharmacology - January 24, 2014 Category: Drugs & Pharmacology Authors: S Kishida, K Kadomatsu Tags: REVIEW Source Type: research

Low-voltage-activated T-type Ca(2+) channel inhibitors as new tools in the treatment of glioblastoma: the role of endostatin.
Abstract Ca(2+) plays a key role in intracellular signaling and controls various cellular processes such as proliferation, differentiation, cell growth, death, and apoptosis. Aberrant changes in intracellular Ca(2+) levels can promote undesired cell proliferation and migration and are therefore associated with certain tumor types. Many research groups have suggested a potential role for voltage-gated Ca(2+) channels in the regulation of tumor growth and progression, particularly T-type channels due to their unique biophysical properties. T-type channels are expressed in normal tissues throughout the body and in di...
Source: Pflugers Archiv : European Journal of Physiology - January 10, 2014 Category: Physiology Authors: Zhang Y, Wang H, Qian Z, Feng B, Zhao X, Jiang X, Tao J Tags: Pflugers Arch Source Type: research

The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.
In conclusion, our findings indicate the potential of the PBOX compounds in enhancing chemosensitivity in neuroblastoma. PMID: 24406249 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - January 6, 2014 Category: Drugs & Pharmacology Authors: Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM Tags: Biochem Pharmacol Source Type: research

Type I interferons up-regulate the expression and signalling of p75 NTR/TrkA receptor complex in differentiated human SH-SY5Y neuroblastoma cells.
Abstract Both type I interferons (IFNs) and neurotrophins regulate neuroadaptive responses, but relatively little is known on the interaction between these two classes of regulatory proteins. Here we investigated the effect of IFN-β on the expression and functional activity of the common neurotrophin receptor p75NTR and the nerve growth factor (NGF) receptor TrkA. In differentiated human SH-SY5Y neuroblastoma cells prolonged exposure to IFN-β up-regulated p75NTR and TrkA levels, failed to affect the content of sortilin, a p75NTR co-receptor, and, consistent with our previous finding, down-regulated the brain-der...
Source: Neuropharmacology - December 11, 2013 Category: Drugs & Pharmacology Authors: Dedoni S, Olianas MC, Ingianni A, Onali P Tags: Neuropharmacology Source Type: research

Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway.
In conclusion, we demonstrated that SH-SY5Y cells undergo an adaptive response against UCB-mediated oxidative stress by activation of multiple antioxidant response, in part through Nrf2 pathway. PMID: 24308969 [PubMed - as supplied by publisher]
Source: Cellular Signalling - December 2, 2013 Category: Cytology Authors: Qaisiya M, Zabetta CC, Bellarosa C, Tiribelli C Tags: Cell Signal Source Type: research

Knockdown of β-catenin expression inhibits neuroblastoma cell growth in vitro and in vivo
Conclusion: β-Catenin knockdown could effectively control growth of neuroblastoma cells in vitro and in nude mice, suggesting that targeting β-catenin may be useful in clinical control of neuroblastoma.
Source: Journal of Pediatric Surgery - December 1, 2013 Category: Surgery Authors: Wei Yao, Kai Li, Shan Zheng, Xianmin Xiao, Yangyang Ma, Xiaowen Zhai Tags: PAPS Papers Source Type: research

Downregulation of PMCA2 increases the vulnerability of midbrain neurons to mitochondrial complex I inhibition.
Abstract Parkinson's disease is an age-associated disorder characterized by selective degeneration of dopaminergic neurons. The molecular mechanisms underlying the selective vulnerability of this subset of neurons are, however, not fully understood. Employing SH-SY5Y neuroblastoma cells and primary mesencephalic neurons, we here demonstrate a significant increase in cytosolic calcium after inhibition of mitochondrial complex I by means of MPP(+), which is a well-established environmental toxin-based in vitro model of Parkinson's disease. This increase in calcium is correlated with a downregulation of the neuron-sp...
Source: Neurotoxicology - November 21, 2013 Category: Neurology Authors: Brendel A, Renziehausen J, Behl C, Hajieva P Tags: Neurotoxicology Source Type: research

PAX3 in neuroblastoma: oncogenic potential, chemosensitivity and signalling pathways
Abstract Transcription factor PAX3/Pax3 contributes to diverse cell lineages during embryonic development and is important in tumourigenesis. We found that PAX3 is re‐expressed in neuroblastoma and malignant neuroblastic (N‐type) neuroblastoma cells had significantly higher PAX3 protein expression than their benign substrate‐adherent (S‐type) counterparts. Knock‐down of PAX3 expression by siRNA transfection resulted in persistent cell growth inhibition in both types of neuroblastoma cell, owing to G1 cell cycle arrest and progressive apoptosis. Inhibition of PAX3 expression significantly decreased the attachment ...
Source: Journal of Cellular and Molecular Medicine - November 4, 2013 Category: Molecular Biology Authors: Wen‐Hui Fang, Qiuyu Wang, Hong‐Mei Li, Mashud Ahmed, Patricia Kumar, Shant Kumar Tags: Original Article Source Type: research

PAX3 in neuroblastoma: oncogenic potential, chemosensitivity and signalling pathways.
Abstract Transcription factor PAX3/Pax3 contributes to diverse cell lineages during embryonic development and is important in tumourigenesis. We found that PAX3 is re-expressed in neuroblastoma and malignant neuroblastic (N-type) neuroblastoma cells had significantly higher PAX3 protein expression than their benign substrate-adherent (S-type) counterparts. Knock-down of PAX3 expression by siRNA transfection resulted in persistent cell growth inhibition in both types of neuroblastoma cell, owing to G1 cell cycle arrest and progressive apoptosis. Inhibition of PAX3 expression significantly decreased the attachment o...
Source: J Cell Mol Med - November 4, 2013 Category: Molecular Biology Authors: Fang WH, Wang Q, Li HM, Ahmed M, Kumar P, Kumar S Tags: J Cell Mol Med Source Type: research