Filtered By:
Cancer: Neuroblastoma

This page shows you your search results in order of date. This is page number 11.

Order by Relevance | Date

Total 288 results found since Jan 2013.

Insights on ornithine decarboxylase silencing as a potential strategy for targeting retinoblastoma
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Sivashanmugam Muthukumaran, Renganathan Bhuvanasundar, Vetrivel Umashankar, K.N. Sulochana Ornithine Decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and is reported to be up regulated in several cancers. However, the effect of ODC gene silencing in retinoblastoma is to be understood for utilization in therapeutic applications. Hence, in this study, a novel siRNA (small interference RNA) targeting ODC was designed and validated in Human Y79 retinoblastoma cells for its effects on intracellular polyamine le...
Source: Biomedicine and Pharmacotherapy - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Insights on ornithine decarboxylase silencing as a potential strategy for targeting retinoblastoma.
Abstract Ornithine Decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and is reported to be up regulated in several cancers. However, the effect of ODC gene silencing in retinoblastoma is to be understood for utilization in therapeutic applications. Hence, in this study, a novel siRNA (small interference RNA) targeting ODC was designed and validated in Human Y79 retinoblastoma cells for its effects on intracellular polyamine levels, Matrix Metalloproteinase 2 & 9 activity and Cell cycle. The designed siRNA showed efficient silencing of ODC mRNA expression and protein levels in Y79 cells. It al...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 11, 2017 Category: Drugs & Pharmacology Authors: Muthukumaran S, Bhuvanasundar R, Umashankar V, Sulochana KN Tags: Biomed Pharmacother Source Type: research

Effects of celastrol on Tau hyperphosphorylation and expression of HSF ‐1 and HSP70 in SH‐SY5Y neuroblastoma cells induced by amyloid‐β peptides
This article is protected by copyright. All rights reserved
Source: Biotechnology and Applied Biochemistry - November 1, 2017 Category: Biochemistry Authors: Fanfan Cao, Ying Wang, Bin Peng, Xue Zhang, Denghai Zhang, Limin Xu Tags: Original Article Source Type: research

Ethanol-induced PGE2 up-regulates A β production through PKA/CREB signaling pathway
In conclusion, ethanol-induced eIF2α phosphorylation stimulates COX-2 expression and PGE2 production which induces the BACE1 expression and Aβ production via EP-2 receptor-dependent PKA/CREB pathway. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - October 10, 2017 Category: Molecular Biology Source Type: research

Knockdown of LRP/LR induces apoptosis in pancreatic cancer and neuroblastoma cells through activation of caspases.
Abstract The 37kDa/67kDa laminin receptor (LRP/LR) serves various physiological and pathological roles such as enhancing tumour-related processes including metastasis, angiogenesis, cellular viability and telomerase activation in cancerous cell lines. The present study investigates the effect of siRNA mediated downregulation of LRP/LR on pancreatic cancer (AsPC-1) and neuroblastoma (IMR-32) cells. MTT and BrdU assays revealed that siRNA mediated downregulation of LRP resulted in a significant reduction in cell viability and cell proliferation. In addition, knock-down of LRP resulted in phosphatidylserine externali...
Source: Experimental Cell Research - September 9, 2017 Category: Cytology Authors: Chetty CJ, Ferreira E, Jovanovic K, Weiss SFT Tags: Exp Cell Res Source Type: research

Fluoxetine induces apoptosis through endoplasmic reticulum stress via mitogen-activated protein kinase activation and histone hyperacetylation in SK-N-BE(2)-M17 human neuroblastoma cells
In this study, the molecular mechanisms underlying the anti-cancer effects of FLX were investigated in SK-N-BE(2)-M17 human neuroblastoma cells. FLX induced apoptotic cell death, activation of caspase-4, -9, and -3, and expression of endoplasmic reticulum (ER) stress-associated proteins, including C/EBP homologous protein (CHOP). Inhibition of ER stress by treatment with the ER stress inhibitors, salubrinal and 4-phenylbutyric acid or CHOP siRNA transfection reduced FLX-induced cell death. FLX induced phosphorylation of mitogen-activated protein kinases (MAPKs) family, p38, JNK, and ERK, and an upstream kinase apoptosis si...
Source: Apoptosis - June 24, 2017 Category: Molecular Biology Source Type: research

Suberoylanilide hydroxamic acid sensitizes neuroblastoma to paclitaxel by inhibiting thioredoxin ‐related protein 14‐mediated autophagy
This study explored the regulatory mechanism of paclitaxel‐associated autophagy and potential solutions to paclitaxel resistance in neuroblastoma. The formation of autophagic vesicles was detected by scanning transmission electron microscopy and flow cytometry. The autophagy‐associated proteins were assessed by western blot. Autophagy was induced and the autophagy‐associated proteins LC3‐I, LC3‐II, Beclin 1, and thioredoxin‐related protein 14 (TRP14), were found to be upregulated in neuroblastoma cells that were exposed to paclitaxel. The inhibition of Beclin 1 or TRP14 by siRNA increased the sensitivity of the...
Source: Cancer Science - June 19, 2017 Category: Cancer & Oncology Authors: Zijun Zhen, Kaibin Yang, Litong Ye, Zhiyao You, Rirong Chen, Ying Liu, Youjian He Tags: Original Article Source Type: research

SAHA sensitizes neuroblastoma to paclitaxel by inhibiting TRP14 ‐mediated autophagy
This study explored the regulatory mechanism of paclitaxel‐associated autophagy and potential solutions to paclitaxel resistance in neuroblastoma. The formation of autophagic vesicles was detected by scanning transmission electron microscopy and flow cytometry. The autophagy‐associated proteins were assessed by western blot. Autophagy was induced and the autophagy‐associated proteins LC3‐I, LC3‐II, Beclin 1, and thioredoxin‐related protein 14 (TRP14), were found to be up‐regulated in neuroblastoma cells that were exposed to paclitaxel. The inhibition of Beclin 1 or TRP14 by siRNA increased the sensitivity of ...
Source: Cancer Science - May 12, 2017 Category: Cancer & Oncology Authors: Zijun Zhen, Kaibin Yang, Litong Ye, Zhiyao You, Rirong Chen, Ying Liu, Youjian He Tags: Original Article Source Type: research

Novel targeted therapy for neuroblastoma: Silencing the MXD3 gene using siRNA.
CONCLUSIONS: These results indicate that MXD3 is a potential new target and MXD3 siRNA nanocomplexes are a novel therapeutic approach for neuroblastoma.Pediatric Research accepted article preview online, 18 April 2017. doi:10.1038/pr.2017.74. PMID: 28419087 [PubMed - as supplied by publisher]
Source: Pediatric Research - April 18, 2017 Category: Pediatrics Authors: Duong C, Yoshida S, Chen C, Barisone G, Diaz E, Li Y, Beckett L, Chung J, Antony R, Nolta J, Nitin N, Satake N Tags: Pediatr Res Source Type: research

Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma
In this study, we demonstrate that Tolcapone kills neuroblastoma (NB) cells in preclinical models by inhibition of COMT. Treating four established NB cells lines (SMS‐KCNR, SH‐SY5Y, BE(2)‐C, CHLA‐90) and two primary NB cell lines with Tolcapone for 48 h decreased cell viability in a dose‐dependent manner, with IncuCyte imaging and Western blotting indicating that cell death was due to caspase‐3‐mediated apoptosis. Tolcapone also increased ROS while simultaneously decreasing ATP‐per‐cell in NB cells. Additionally, COMT was inhibited by siRNA in NB cells and showed similar increases in apoptotic markers co...
Source: Cancer Medicine - April 1, 2017 Category: Cancer & Oncology Authors: Tyler Maser, Maria Rich, David Hayes, Ping Zhao, Abhinav B. Nagulapally, Jeffrey Bond, Giselle Saulnier Sholler Tags: Original Research Source Type: research

Hemin protects against oxygen-glucose deprivation-induced apoptosis activation via neuroglobin in SH-SY5Y cells.
This study aimed to investigate the mechanism underlying the neuroprotective effect of hemin in oxygen-glucose deprivation (OGD)-treated neurons. OGD-treated SH-SY5Y cells (human neuroblastoma cells) were used in the study. The cellular viability of SH-SY5Y cells was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the cell apoptosis rate was determined by flow cytometry analysis with Annexin V-fluorescein isothiocyanate and propidium iodide staining with or without hemin pretreatment. Cell viability and apoptotic activation were detected after hemin administration combined with neuro...
Source: Neurochemical Research - March 18, 2017 Category: Neuroscience Authors: Wang YJ, Peng QY, Deng SY, Chen CX, Wu L, Huang L, Zhang LN Tags: Neurochem Res Source Type: research

The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma.
CONCLUSIONS: Overall, these data demonstrate that prexasertib is a specific inhibitor of CHK1 in neuroblastoma and leads to DNA damage and cell death in preclinical models of this devastating pediatric malignancy. PMID: 28270495 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - March 6, 2017 Category: Cancer & Oncology Authors: Lowery CD, VanWye AB, Dowless M, Blosser W, Falcon BL, Stewart J, Stephens J, Beckmann RP, Bence Lin A, Stancato LF Tags: Clin Cancer Res Source Type: research

Targeted inhibition of HDAC8 increases the doxorubicin sensitivity of neuroblastoma cells via up regulation of miR-137.
Abstract Histone deacetylases (HDACs) have been suggested to be potential therapeutic targets for cancer treatment. Recent studies revealed that HDAC8 expression was associated with poor prognostic markers and poor overall survival rate of neuroblastoma (NB). Our present study revealed that among the four members of class I HDACs, HDAC8 is significantly over expressed in NB cells as compared with the normal fibroblast 3T3 cells or primary normal human astrocytes (NHA) cells. Targeted inhibition of HDAC8 by its specific siRNA (si-HDAC8) can inhibit the in vitro growth of NB cells. Furthermore, si-HDAC8 significantl...
Source: European Journal of Pharmacology - February 17, 2017 Category: Drugs & Pharmacology Authors: Zhao G, Wang G, Bai H, Li T, Gong F, Yang H, Wen J, Wang W Tags: Eur J Pharmacol Source Type: research

Calcipotriol inhibits α‐synuclein aggregation in SH‐SY5Y neuroblastoma cells by a Calbindin‐D28K‐dependent mechanism
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - February 5, 2017 Category: Neuroscience Authors: Alexandre N. Rcom ‐H'cheo‐Gauthier, Adrian C. B. Meedeniya, Dean L. Pountney Tags: Original Article Source Type: research

Capillarisin augments anti-oxidative and anti-inflammatory responses by activating Nrf2/HO-1 signaling
Publication date: Available online 1 February 2017 Source:Neurochemistry International Author(s): Jinhee Kim, Juhee Lim, Bok Yun Kang, Kiwon Jung, Hyun Jin Choi Capillarisin is a naturally isolated chromone, which is one of the major bioactive constituents of Artemisia capillaries. Capillarisin has antioxidant, anti-inflammatory, and anti-tumor potential, but the underlying molecular mechanisms remain largely unclear. In the present study, we demonstrate that the transcription factor nuclear factor E2-related factor-2 (Nrf2) is activated by capillarisin in neuroblastoma SH-SY5Y cells and microglial BV2 cells. Capillarisin...
Source: Neurochemistry International - January 31, 2017 Category: Neuroscience Source Type: research