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Total 879 results found since Jan 2013.

Kindlin-2 promotes invasiveness of prostate cancer cells via NF-κB-dependent upregulation of matrix metalloproteinases.
In this study, we aimed to investigate the role of kindlin-2, a integrin-binding focal adhesion protein, in the regulation of invasiveness of prostate cancer. We found that downregulation of kindlin-2 using small interfering RNA (siRNA) technology significantly inhibited the invasion of PC-3 and DU-145 prostate cancer cells in a Matrigel Transwell assay. Conversely, overexpression of kindlin-2 promoted the invasiveness of prostate cancer cells. Kindlin-2 overexpression was found to activate nuclear factor (NF)-κB-dependent signaling and upregulate the expression of matrix metalloproteinase-9 (MMP-9) and MMP-2, whereas kin...
Source: Gene - November 6, 2015 Category: Genetics & Stem Cells Authors: Yang JR, Pan TJ, Yang H, Wang T, Liu W, Liu B, Qian WH Tags: Gene Source Type: research

Systemic PSMA-Targeted IR Sensitization
Radiation therapy is a highly effective tool for treating all stages of prostate cancer, from curative approaches in localized disease to palliative care and enhanced survival for patients with distant bone metastases. The therapeutic index of these approaches may be enhanced with targeted radiation-sensitizing agents. Aptamers are promising nucleic acid delivery agents for short interfering RNAs (siRNA) and short hairpin RNAs (shRNA). We have previously developed a radiation-sensitizing RNA aptamer–shRNA chimera that selectively delivers DNA-PK targeting shRNAs to prostate-specific membrane antigen (PSMA) positive c...
Source: Molecular Cancer Therapeutics - December 6, 2015 Category: Cancer & Oncology Authors: Ni, X., Zhang, Y., Zennami, K., Castanares, M., Mukherjee, A., Raval, R. R., Zhou, H., DeWeese, T. L., Lupold, S. E. Tags: Large Molecule Therapeutics Source Type: research

Abstract C1: Harnessing the pro-inflammatory tumor microenvironment of castrate-resistant prostate cancer to promote apoptosis
ConclusionProstate cancer cell lines are inherently resistant to SMAC mimetic therapy even in the presence of TNFα or TRAIL. However, dual targeting of FLIP and IAPs sensitises CRPC cell lines to microenvironment-derived TNFα. Combined targeting of IAPs and FLIP, or single targeting of FLIP, may be an effective means of treating pro-inflammatory prostate cancer.Citation Format: Christopher McCann, Nyree Crawford, David Waugh, Daniel Longley. Harnessing the pro-inflammatory tumor microenvironment of castrate-resistant prostate cancer to promote apoptosis. [abstract]. In: Proceedings of the AACR-NCI-EORTC Interna...
Source: Molecular Cancer Therapeutics - January 7, 2016 Category: Cancer & Oncology Authors: McCann, C., Crawford, N., Waugh, D., Longley, D. Tags: Apoptosis, Necrosis, and Autophagy: Poster Presentations - Proffered Abstracts Source Type: research

TR4 nuclear receptor enhances the cisplatin chemo-sensitivity via altering the ATF3 expression to better suppress HCC cell growth.
Authors: Jiliang S, Hui L, Gonghui L, Renan J, Liang S, Mingming C, Chawnshang C, Xiujun C Abstract Early studies indicated that TR4 nuclear receptor (TR4) may play a key role to modulate the prostate cancer progression, its potential linkage to liver cancer progression, however, remains unclear. Here we found that higher TR4 expression in hepatocellular carcinoma (HCC) cells might enhance the efficacy of cisplatin chemotherapy to better suppress the HCC progression. Knocking down TR4 with TR4-siRNA in HCC Huh7 and Hep3B cells increased cisplatin chemotherapy resistance and overexpression of TR4 with TR4-cDNA in HC...
Source: Oncotarget - April 8, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Abstract B02: miR-1207-3p as a potential prostate cancer biomarker in Black males
In conclusion, we have discovered a novel miR-1207-3p-dependent FNDC1/FN1/AR molecular pathway that regulates proliferation of PCA cells derived from Black males. Consequently, miR-1207-3p may be a biomarker in PCA with potential clinical applications in Black males.Citation Format: Dibash Kumar Das, Adeodat Ilboudo, Olorunseun O. Ogunwobi. miR-1207-3p as a potential prostate cancer biomarker in Black males. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Ep...
Source: Cancer Epidemiology Biomarkers and Prevention - April 14, 2016 Category: Cancer & Oncology Authors: Das, D. K., Ilboudo, A., Ogunwobi, O. O. Tags: Biomarkers in Cancer Surveillance and Screening: Poster Presentations - Proffered Abstracts Source Type: research

Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling
Conclusion Curcumin induced apoptosis and G0/G1 arrest in DU-145 cells by down regulating Notch signaling.
Source: Biomedicine and Pharmacotherapy - September 19, 2016 Category: Drugs & Pharmacology Source Type: research

Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling.
CONCLUSION: Curcumin induced apoptosis and G0/G1 arrest in DU-145 cells by down regulating Notch signaling. PMID: 27657825 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2016 Category: Drugs & Pharmacology Authors: Sha J, Li J, Wang W, Pan L, Cheng J, Li L, Zhao H, Lin W Tags: Biomed Pharmacother Source Type: research

Simvastatin Up ‐Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen‐Independent Human Prostate Cancer Cells
CONCLUSIONOur results suggest that statins inhibit the proliferation, migration, and invasion of androgen‐independent prostate cancer cells by up‐regulation of ANXA10. Additionally, it is possible that S100A4 plays a role in these effects. Statins may be beneficial in the prevention and/or treatment of prostate cancer. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - November 7, 2016 Category: Urology & Nephrology Authors: Yoshiyuki Miyazawa, Yoshitaka Sekine, Haruo Kato, Yosuke Furuya, Hidekazu Koike, Kazuhiro Suzuki Tags: Original Article Source Type: research

Basic helix-loop-helix transcription factor DEC2 functions as an anti-apoptotic factor during paclitaxel-induced apoptosis in human prostate cancer cells.
In conclusion, DEC1, at least partly, exerted a pro-apoptotic effect, whereas DEC2 exerted an anti-apoptotic effect in paclitaxel-induced apoptosis of human prostate cancer cells. PMID: 27840924 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - November 7, 2016 Category: Molecular Biology Authors: Liu Q, Wu Y, Yoshizawa T, Yan X, Morohashi S, Seino H, Kato Y, Kijima H Tags: Int J Mol Med Source Type: research

Farnesoid X receptor ligand CDCA suppresses human prostate cancer cells growth by inhibiting lipid metabolism via targeting sterol response element binding protein 1.
CONCLUSION: Our study indicates that activation of FXR inhibits lipid metabolism via SREBP1 pathway and further suppresses prostate tumor growth in vitro. PMID: 27904713 [PubMed - in process]
Source: American Journal of Translational Research - December 3, 2016 Category: Research Tags: Am J Transl Res Source Type: research

ZFP91: A Noncanonical NF- κB Signaling Pathway Regulator with Oncogenic Properties Is Overexpressed in Prostate Cancer.
ZFP91: A Noncanonical NF-κB Signaling Pathway Regulator with Oncogenic Properties Is Overexpressed in Prostate Cancer. Biomed Res Int. 2016;2016:6963582 Authors: Paschke L, Jopek K, Szyszka M, Tyczewska M, Ziolkowska A, Rucinski M, Malendowicz LK Abstract Novel molecular targets are being searched to aid in prostate cancer diagnosis and therapy. Recently, ZFP91 zinc finger protein has been found to be upregulated in prostate cancer cell lines. It is a potentially important oncogenic protein; however only limited data regarding its biological function and expression patterns are available. To date, ZF...
Source: Biomed Res - December 17, 2016 Category: Research Authors: Paschke L, Jopek K, Szyszka M, Tyczewska M, Ziolkowska A, Rucinski M, Malendowicz LK Tags: Biomed Res Int Source Type: research

Physical and Functional Interactions between ELL2 and RB in the Suppression of Prostate Cancer Cell Proliferation, Migration, and Invasion.
Abstract Elongation factor, RNA polymerase II, 2 (ELL2) is expressed and regulated by androgens in the prostate. ELL2 and ELL-associated factor 2 (EAF2) form a stable complex, and their orthologs in Caenorhabditis elegans appear to be functionally similar. In C. elegans, the EAF2 ortholog eaf-1 was reported to interact with the retinoblastoma (RB) pathway to control development and fertility in worms. Because RB loss is frequent in prostate cancer, ELL2 interaction with RB might be important for prostate homeostasis. The present study explored physical and functional interaction of ELL2 with RB in prostate cancer....
Source: Neoplasia - February 2, 2017 Category: Cancer & Oncology Authors: Qiu X, Pascal LE, Song Q, Zang Y, Ai J, O'Malley KJ, Nelson JB, Wang Z Tags: Neoplasia Source Type: research

Stanniocalcin 1 promotes cell proliferation via cyclin  E1/cyclin‑dependent kinase 2 in human prostate carcinoma.
Stanniocalcin 1 promotes cell proliferation via cyclin E1/cyclin‑dependent kinase 2 in human prostate carcinoma. Oncol Rep. 2017 Mar 13;: Authors: Bai Y, Xiao Y, Dai Y, Chen X, Li D, Tan X, Zhang X Abstract Stanniocalcin 1 (STC1) is a glycoprotein hormone that is involved in calcium/phosphate homeostasis. Increasing evidence suggests that STC1 is involved in carcinogenesis; however, few studies have defined the mechanisms and functional roles of STC1 activity in prostate carcinogenesis. In the present study, MTT, flow cytometry and colony formation assays, and small interfering RNA (siRNA) and overe...
Source: Oncology Reports - March 31, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Snail transcription factor NLS and importin β1 regulate the subcellular localization of Cathepsin L and Cux1.
Abstract Several recent studies have highlighted an additional unexpected localization and site of action for Cathepsin L (Cat L) protease within the nucleus in breast, colon and prostate cancer, however, its role in the nucleus was unclear. It was proposed to mediate proteolytic processing of the transcription factor CCAAT-displacement protein/cut homeobox transcription factor (Cux1) from the full-length p200 isoform to generate the p110 and p90 isoforms, of which the p110 isoform was shown to act as a cell cycle regulator to accelerate entry into the S phase. The p110 isoform has also been shown to bind to the p...
Source: Biochemical and Biophysical Research communications - July 8, 2017 Category: Biochemistry Authors: Burton LJ, Henderson V, Liburd L, Odero-Marah VA Tags: Biochem Biophys Res Commun Source Type: research

The orally active pterocarpanquinone LQB ‐118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress
ConclusionLQB‐118 is a developing and orally active pterocarpanquinone agent that effectively kills PCa cells through quinone reduction and ROS generation. The inhibition SOD1 expression enhances LQB‐118 activity, presumably by impairing the cellular antioxidant response.
Source: The Prostate - November 6, 2017 Category: Urology & Nephrology Authors: Thiago Martino, Tarana A. Kudrolli, Binod Kumar, Isis Salviano, Andr é Mencalha, Marsen Garcia P. Coelho, Graça Justo, Paulo R. Ribeiro Costa, Kátia C. Carvalho Sabino, Shawn E. Lupold Tags: ORIGINAL ARTICLE Source Type: research