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Condition: Benign Prostatic Hyperplasia
Cancer: Prostate Cancer

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Total 110 results found since Jan 2013.

Ratio of the expression levels of androgen receptor splice variant 7 to androgen receptor in castration refractory prostate cancer
Oncol Lett. 2021 Dec;22(6):831. doi: 10.3892/ol.2021.13092. Epub 2021 Oct 13.ABSTRACTIn clinical samples, the expression of androgen receptor (AR) and of AR splice variant 7 (AR-V7) is higher in castration-resistant prostate cancer (CRPC) compared with that in hormone-sensitive prostate cancer (PCa). However, there are only a few reports on the ratio of the expression levels of AR-V7 to AR (AR-V7/AR) in prostate tissue. The present study evaluated AR-V7/AR expression in various types of human prostate tissues and CRPC cells. Pretreatment prostate tissue samples from patients with benign prostatic hyperplasia (BPH; n=18), G...
Source: Oncology Letters - October 25, 2021 Category: Cancer & Oncology Authors: Yoshitaka Sekine Hiroshi Nakayama Yoshiyuki Miyazawa Seiji Arai Hidekazu Koike Hiroshi Matsui Yasuhiro Shibata Kazuto Ito Kazuhiro Suzuki Source Type: research

Expression and ERG regulation of PIM kinases in prostate cancer
Our data demonstrate for the first time that expression levels of all three PIM family kinases can be upregulated during prostate cancer progression and can thereby significantly contribute to this process, especially in cooperation with other co ‐overexpressed oncoproteins, such as MYC and ERG, as shown here. The increased PIM expression levels may in turn be explained by our novel observation that ERG can induce transcription of allPIM family genes. AbstractThe three oncogenic PIM family kinases have been implicated in the development of prostate cancer (PCa). The aim of this study was to examine the mRNA and protein e...
Source: Cancer Medicine - May 1, 2021 Category: Cancer & Oncology Authors: Sini K. Eerola, Annika Kohvakka, Teuvo L. J. Tammela, P äivi J. Koskinen, Leena Latonen, Tapio Visakorpi Tags: ORIGINAL RESEARCH Source Type: research

Analysis of the expression and association of retinoblastoma binding protein 6 (RBBP6) with the JNK signaling pathway in prostate cancers.
This study aims to investigate the expression of retinoblastoma binding protein 6 (RBBP6) in prostate cancer (PCa) and its association with the c-Jun N-terminal kinase (JNK) pathway. Immunohistochemistry was used to detect RBBP6 and JNK1/2 expression in PCa and benign prostatic hyperplasia (BPH) tissues. RBBP6 expression in PCa cells (LNCap, PC3 and DU145) and noncancerous prostate epithelial cells (RWPE-1) was determined by qRT-PCR and Western blotting. PC3 and DU145 cells were transfected with RBBP6 siRNAs to examine the biological characteristics. Anisomycin (a JNK activator) with/without RBBP6 siRNA was used to treat P...
Source: Cell Biology International - July 13, 2020 Category: Cytology Authors: Guan WY, Zhao S, Luo YN Tags: Cell Biol Int Source Type: research

Cancers, Vol. 12, Pages 1122: The Role of lncRNAs TAPIR-1 and -2 as Diagnostic Markers and Potential Therapeutic Targets in Prostate Cancer
Muders Sommer Baretton Wirth Horn In search of new biomarkers suitable for the diagnosis and treatment of prostate cancer, genome-wide transcriptome sequencing was carried out with tissue specimens from 40 prostate cancer (PCa) and 8 benign prostate hyperplasia patients. We identified two intergenic long non-coding transcripts, located in close genomic proximity, which are highly expressed in PCa. Microarray studies on a larger cohort comprising 155 patients showed a profound diagnostic potential of these transcripts (AUC~0.94), which we designated as tumor associated prostate cancer increased lncRNA (TAP...
Source: Cancers - April 29, 2020 Category: Cancer & Oncology Authors: Friedrich Wiedemann Reiche Puppel Pfeifer Zipfel Binder K öhl M üller Engeland Aigner F üssel Fr öhner Peitzsch Dubrovska Rade Christ Schreiber Hackerm üller Lehmann Toma Muders Sommer Baretton Wirth Horn Tags: Article Source Type: research

URG11 Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion.
Abstract Upregulated gene 11 (URG11), a new gene upregulated by hepatitis B virus X protein, is involved in the development and progression of several tumors, including liver, stomach, lung, and colon cancers. However, the role of URG11 in prostate cancer remains yet to be elucidated. By determined expression in human prostate cancer tissues, URG11 was found significantly upregulated and positively correlated with the severity of prostate cancer, compared with that in benign prostatic hyperplasia tissues. Further, the mRNA and protein levels of URG11 were significantly upregulated in human prostate cancer cell lin...
Source: Biomed Res - June 30, 2018 Category: Research Authors: Pan B, Ye Y, Liu H, Zhen J, Zhou H, Li Y, Qu L, Wu Y, Zeng C, Zhong W Tags: Biomed Res Int Source Type: research

Role of connexin 43 in cadmium ‐induced proliferation of human prostate epithelial cells
In this study, the human prostate epithelial cell line RWPE‐1 was exposed to Cd. A low dose of Cd stimulated cell proliferation along with a lower degree of gap junction intercellular communication and an elevated level of the protein Cx43. Cd exposure increased the levels of intracellular Ca2+ and phosphorylated Cx43 at the Ser368 site. Knockdown of Cx43 using siRNA blocked Cd‐induced proliferation and interfered with the Cd‐induced changes in the protein levels of cyclin D1, cyclin B1, p27Kip1 (p27) and p21Waf1/Cip1 (p21). The increase in Cx43 expression induced by Cd was presumably mediated by the androgen recepto...
Source: Journal of Applied Toxicology - February 7, 2017 Category: Toxicology Authors: Qingping Liu, Xiaoli Ji, Zehe Ge, Haipeng Diao, Xiuli Chang, Lihua Wang, Qing Wu Tags: Research article Source Type: research

Simvastatin Up ‐Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen‐Independent Human Prostate Cancer Cells
CONCLUSIONOur results suggest that statins inhibit the proliferation, migration, and invasion of androgen‐independent prostate cancer cells by up‐regulation of ANXA10. Additionally, it is possible that S100A4 plays a role in these effects. Statins may be beneficial in the prevention and/or treatment of prostate cancer. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - November 7, 2016 Category: Urology & Nephrology Authors: Yoshiyuki Miyazawa, Yoshitaka Sekine, Haruo Kato, Yosuke Furuya, Hidekazu Koike, Kazuhiro Suzuki Tags: Original Article Source Type: research

Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer.
Authors: Soekmadji C, Riches JD, Russell PJ, Ruelcke JE, McPherson S, Wang C, Hovens CM, Corcoran NM, The Australian Prostate Cancer Collaboration BioResource, Hill MM, Nelson CC Abstract Proliferation and maintenance of both normal and prostate cancer (PCa) cells is highly regulated by steroid hormones, particularly androgens, and the extracellular environment. Herein, we identify the secretion of CD9 positive extracellular vesicles (EV) by LNCaP and DUCaP PCa cells in response to dihydrotestosterone (DHT) and use nano-LC-MS/MS to identify the proteins present in these EV. Subsequent bioinformatic and pathway anal...
Source: Oncotarget - August 16, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer.
This study supports an oncogenic role for CYP1A1 in prostate cancer via promoter hypomethylation that is influenced by tobacco smoking, indicating CYP1A1 to be a promising target for prostate cancer treatment. PMID: 27203547 [PubMed - as supplied by publisher]
Source: Oncotarget - May 21, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

SATB1 promotes prostate cancer metastasis by the regulation of epithelial-mesenchymal transition.
In this study SATB1 expression vector or siRNA was employed to modulate the expression level of SATB1 in prostate cancer cells and xenograft tumor in nude mouse model. Immunohistochemical analysis was performed on clinical prostate cancer samples. Silencing SATB1 inhibited the growth of DU-145 cells subcutaneous tumor in nude mice, while SATB1 overexpression promoted the growth of LNCaP cells subcutaneous tumor in nude mice. Immunohistochemical and Western blot analysis of the xenografts showed that silencing SATB1 led to decreased expression of vimentin and MMP2 and increased expression of E-cadherin, while SATB1 overexpr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2016 Category: Drugs & Pharmacology Authors: Mao LJ, Yang CH, Fan L, Gao P, Yang DR, Xue BX, Zheng JN, Shan YX Tags: Biomed Pharmacother Source Type: research

SATB1 promotes prostate cancer metastasis by the regulation of epithelial–mesenchymal transition
In this study SATB1 expression vector or siRNA was employed to modulate the expression level of SATB1 in prostate cancer cells and xenograft tumor in nude mouse model. Immunohistochemical analysis was performed on clinical prostate cancer samples. Silencing SATB1 inhibited the growth of DU-145 cells subcutaneous tumor in nude mice, while SATB1 overexpression promoted the growth of LNCaP cells subcutaneous tumor in nude mice. Immunohistochemical and Western blot analysis of the xenografts showed that silencing SATB1 led to decreased expression of vimentin and MMP2 and increased expression of E-cadherin, while SATB1 overexpr...
Source: Biomedicine and Pharmacotherapy - February 11, 2016 Category: Drugs & Pharmacology Source Type: research

Abstract A16: Different epigenetic mechanisms involved in the regulation of SFRP1 gene in prostate cancer
Among men, prostate cancer (PCa)[1] is the second most common cancer and the fifth cause of death worldwide [2]. Androgens play an important role in the development of the disease. For advanced PCa the standard therapy is androgen depletion. However, after 2 or 3 years a high percentage of patients become resistant to this therapy and castration resistant prostate cancer (CRPC) is developed. There is no successful treatment for CRPC, leading into death [3, 4]. Wingless pathway (WNT) is aberrantly activated in several cancer types and in PCa it is involved in AR activity modulation, promoting cancer development [5]. Secrete...
Source: Cancer Research - January 14, 2016 Category: Cancer & Oncology Authors: Garcia–Tobilla, P., Uribe, O., Rodriguez–Dorantes, M. Tags: Epigenetic Control of Transcription/ Elongation Source Type: research

27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells
In this study, we determined the effect of 27-OHC in human prostate epithelial cells RWPE-1. We found that 27-OHC stimulates proliferation and increases androgen receptor (AR) transcriptional activity. 27-OHC also increased prostate-specific antigen expression and enhanced AR binding to the androgen response element compared to controls. Silencing AR expression with siRNA markedly reduced the 27-OHC-induced proliferation. Furthermore, 27-OHC blocked docetaxel-induced apoptosis. Altogether, our results suggest that 27-OHC may play an important role in PCa and BPH progression by promoting proliferation and suppressing apoptosis.
Source: Medical Oncology - January 5, 2016 Category: Cancer & Oncology Source Type: research

Inhibition of LDHA suppresses tumor progression in prostate cancer
Abstract A key hallmark of cancer cells is their altered metabolism, known as Warburg effect. Lactate dehydrogenase A (LDHA) executes the final step of aerobic glycolysis and has been reported to be involved in the tumor progression. However, the function of LDHA in prostate cancer has not been studied. In current study, we observed overexpression of LDHA in the clinical prostate cancer samples compared with benign prostate hyperplasia tissues as demonstrated by immunohistochemistry and real-time qPCR. Attenuated expression of LDHA by siRNA or inhibition of LDHA activities by FX11 inhibited cell proliferation, mig...
Source: Tumor Biology - May 16, 2015 Category: Cancer & Oncology Source Type: research