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Cancer: Hepatocellular Carcinoma

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Total 36590 results found since Jan 2013.

Study of the association between five polymorphisms and risk of hepatocellular carcinoma: A meta-analysis
Conclusion Our findings supported the proposition that the polymorphisms of miR-146a rs2910164, miR-196a2 rs11614913, and miR-196a2 rs11614913 may contribute to the susceptibility of HCC.
Source: Journal of the Chinese Medical Association - February 7, 2017 Category: Journals (General) Source Type: research

Establishing Efficient Systems through Electronic Medical Records to Promote Intra-hospital Referrals of Hepatitis Virus Carriers to Hepatology Specialists: A Multicenter Questionnaire-based Survey of 1,281 Healthcare Professionals.
Conclusion More widespread education of healthcare personnel is important to increase the number of individuals receiving appropriate treatment from specialist physicians. PMID: 33518608 [PubMed - in process]
Source: Internal Medicine - February 3, 2021 Category: Internal Medicine Tags: Intern Med Source Type: research

In memoriam Dimitrios Trichopoulos: an argonaut in search of the golden fleece of medicine (1938–2014)
On December 1, 2014, the epidemiology community bade farewell to one of its most distinguished members. Dimitrios Trichopoulos passed away leaving several colleagues and students in both sides of the Atlantic and all over the world saddened by the loss of a great scientist, mentor and friend. Dimitrios Trichopoulos was Professor of Cancer Prevention and Professor of Epidemiology at the Harvard School of Public Health, Member of the Athens Academy and President of the Hellenic Health Foundation in Greece. He had served as director of the Harvard Center for Cancer Prevention; chairman of the Epidemiology Departments at the U...
Source: European Journal of Epidemiology - March 15, 2015 Category: Epidemiology Source Type: research

Liver Diseases in Latin America: Current Status, Unmet Needs, and Opportunities for Improvement
AbstractPurpose of reviewTo assess the current challenges regarding liver diseases, including the burden of disease, access to care, screening, and treatment needs in Latin America.Recent findingsLatin America is a region with a rich multicultural heritage and important socioeconomic differences. The burden of liver diseases is high and mainly determined by a high level of alcohol intake and the surge of risk factors associated with NAFLD (i.e., sedentary lifestyles, broader access to highly processed foods, obesity, and type 2 diabetes mellitus). Hepatotropic viruses also play a role in the development of chronic liver di...
Source: Current Treatment Options in Gastroenterology - June 16, 2022 Category: Gastroenterology Source Type: research

Thyroid metastasis from small cell lung carcinoma: a case report and review of the literature
Conclusions We conclude that in a patient with a known history of malignant disease, the finding of a new thyroid mass should be promptly evaluated with a thyroid fine-needle aspiration biopsy to search for metastatic disease. The clinical features of our and two previously reported cases were summarized.
Source: Journal of Medical Case Reports - October 7, 2015 Category: Journals (General) Source Type: research

Prognostic Value of VEGF in Hepatocellular Carcinoma Patients Treated with Sorafenib: A Meta-Analysis.
CONCLUSIONS High level of VEGF is associated with poor outcomes in HCC patients treated with sorafenib, indicating that VEGF could be used as an indicator of clinical efficacy in patients with HCC. However, more well-designed studies are needed to strengthen our findings. PMID: 26476711 [PubMed - in process]
Source: Medical Science Monitor - October 21, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Biomarker Analyses of Clinical Outcomes in Patients With Advanced Hepatocellular Carcinoma Treated With Sorafenib With or Without Erlotinib in the SEARCH Trial.
CONCLUSIONS: Baseline plasma HGF, VEGF-A, KIT, and VEGF-C correlated with clinical outcomes in HCC patients treated with sorafenib with or without erlotinib. These biomarkers plus epigen constituted a multimarker signature for improved OS. PMID: 27220960 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - May 23, 2016 Category: Cancer & Oncology Authors: Zhu AX, Kang YK, Rosmorduc O, Evans TR, Santoro A, Ross P, Gane E, Vogel A, Jeffers M, Meinhardt G, Pena C Tags: Clin Cancer Res Source Type: research

Benefits of long-term therapy with nucleos(t)ide analogues in treatment-na ïve patients with chronic hepatitis B.
CONCLUSIONS: Long-term administration is generally advised in all CHB patients treated with NAs because of the high rates of virological and clinical relapse after stopping therapy. The findings of this analysis lend support to the choice of highly potent agents with a low drug resistance profile to maximize viral suppression in CHB patients and halt or delay progression to end-stage liver disease. PMID: 27882776 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - November 26, 2016 Category: Research Tags: Curr Med Res Opin Source Type: research

Hepatic resection combined with radiofrequency ablation versus hepatic resection alone for multifocal hepatocellular carcinomas: A meta-analysis
SummaryThis meta-analysis aimed to comprehensively assess the efficacy and safety of hepatic resection combined with radiofrequency ablationversus hepatic resection (HR) alone for the treatment of multifocal hepatocellular carcinomas (HCC). A literature search was conducted from the database including MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and China Biology Medicine (CBM) disc. The primary outcomes included the 1-, 3-, 5-year overall survival (OS) and disease-free survival (DFS) rate. The secondary outcomes contained the intraoperative parameters and postoperative adverse events (AEs). Th...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - December 1, 2017 Category: Research Source Type: research

Molecules, Vol. 23, Pages 567: Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search
heng Luo Kai Chen SET7, serving as the only histone methyltransferase that monomethylates ‘Lys-4’ of histone H3, has been proved to function as a key regulator in diverse biological processes, such as cell proliferation, transcriptional network regulation in embryonic stem cell, cell cycle control, protein stability, heart morphogenesis and development. What′s more, SET7 is involved inthe pathogenesis of alopecia aerate, breast cancer, tumor and cancer progression, atherosclerosis in human carotid plaques, chronic renal diseases, diabetes, obesity, ovarian cancer, prostate cancer, hepatocellular carcinoma, and ...
Source: Molecules - March 2, 2018 Category: Chemistry Authors: Hong Ding Wen Lu Jun Hu Yu-Chih Liu Chen Zhang Fu Lian Nai Zhang Fan Meng Cheng Luo Kai Chen Tags: Article Source Type: research

Association of coffee consumption and liver fibrosis progression in patients with HBeAg-negative chronic hepatitis B: A 5-year population-based cohort study
ConclusionsCoffee consumption was not associated with fibrosis progression or HCC risk in chronic hepatitis B patients over the 5-year observation period.
Source: Journal of the Formosan Medical Association - August 17, 2018 Category: General Medicine Source Type: research

Long noncoding RNA TPTE2P1 promotes the migration and invasion of hepatocellular carcinoma.
CONCLUSIONS: In summary, our results suggested that lncRNA-TPTE2P1 functioned as an oncogene in HCC. Meanwhile, lncRNA-TPTE2P1 stimulated HCC cell migration and invasion by promoting EMT. LncRNA-TPTE2P1 might play a vital role in the development and progression of HCC. Our findings demonstrated that lncRNA-TPTE2P1 could serve as an early biomarker of metastasis and therapeutic target for HCC. PMID: 31114999 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - May 24, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Racial Diversity in Hepatocellular Carcinoma in a Predominately African-American Population at an Urban Medical Center
ConclusionGiven the low surveillance rates and the demonstrated increased survival for patients with small tumors, ways to increase surveillance must be initiated. The results of this study demonstrate the need for physician/patient education on the importance of surveillance US. Further, this study supports routine assessment of APRI in AA patients in an effort to identify patients in whom intensive surveillance will significantly improve earlier detection of tumors.
Source: Journal of Gastrointestinal Cancer - December 1, 2019 Category: Cancer & Oncology Source Type: research

Effect of Oleanolic Acid on Apoptosis and Autophagy of SMMC-7721 Hepatoma Cells.
CONCLUSIONS The study findings suggest that OA combined with autophagy inhibitor 3-MA can better exert its anticancer effect. PMID: 32424110 [PubMed - in process]
Source: Medical Science Monitor - May 21, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Beyond the vascular profile: conventional DWI, IVIM and kurtosis in the assessment of hepatocellular carcinoma.
CONCLUSIONS: DWI should be an integral part of study protocol for HCC patients, considering the great advantages due to DWI and DWI-based approaches in detection and characterization of HCC. PMID: 32706066 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 28, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research