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Cancer: Brain Cancers

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Total 371 results found since Jan 2013.

Absence of susceptibility vessel sign and hyperdense vessel sign in patients with cancer-related stroke
ConclusionThe absence of SVS but not HVS could help to identify paraneoplastic hypercoagulability in stroke patients with active cancer and guide patient care.
Source: Frontiers in Neurology - March 20, 2023 Category: Neurology Source Type: research

Artificial Hibernation by Phenothiazines: A Potential Neuroprotective Therapy Against Cerebral Inflammation in Stroke.
CONCLUSION: This study showed an inhibitory effect of C+P on brain inflammation, which may be partially dependent on drug-induced hibernation, as well as other mechanisms of action by these drugs. These findings further suggest the great potential of C+P in the clinical treatment of ischemic stroke. PMID: 31232236 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - June 23, 2019 Category: Neurology Authors: Guan L, Guo S, Yip J, Elkin KB, Li F, Peng C, Geng X, Ding Y Tags: Curr Neurovasc Res Source Type: research

Case Report: Brain Metastasis Confined to the Infarcted Area Following Stroke
Conclusions: Cerebral infarctions can cause neovascularization and disruption of the blood–brain barrier. Moreover, the compartmentalized cavity formed by the ischemic injury may accept a large volume of metastatic tumor cells. Such an altered microenvironment of infarcted tissue would be suitable for the colonization and proliferation of metastatic seed. Further, brain metastases should be considered, in addition to recurrence, when new focal neurological deficits develop in patients with ischemic stroke and comorbid cancer.
Source: Frontiers in Neurology - January 29, 2021 Category: Neurology Source Type: research

Serum Level of Transferrin Unique Peptide Is Decreased in Patients With Acute Ischemic Stroke
Conclusions: Serum TF-UP/LRP level is decreased in patients with acute ischemic stroke in comparison with brain tumor, and it may serve as a serum biomarker for the neuronal/glial cell damage in cerebral infarction.
Source: Frontiers in Neurology - February 5, 2021 Category: Neurology Source Type: research

Plasticity beyond peri-infarct cortex: Spinal up regulation of structural plasticity, neurotrophins, and inflammatory cytokines during recovery from cortical stroke.
Abstract Stroke induces pathophysiological and adaptive processes in regions proximal and distal to the infarct. Recent studies suggest that plasticity at the level of the spinal cord may contribute to sensorimotor recovery after cortical stroke. Here, we compare the time course of heightened structural plasticity in the spinal cord against the temporal profile of cortical plasticity and spontaneous behavioral recovery. To examine the relation between trophic and inflammatory effectors and spinal structural plasticity, spinal expression of brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), tumor necr...
Source: Experimental Neurology - November 26, 2013 Category: Neurology Authors: Sist B, Fouad K, Winship IR Tags: Exp Neurol Source Type: research

Stroke in Children With Cancer: The Tip of the Iceberg?
We read with great interest the article by Noje et al. in which they analyzed the incidence and characteristics of stroke in children with cancer. Among a population of 1411 children with cancer, during a 10-year period registry, 15 children had stroke, corresponding to an overall prevalence of 1%. A slightly increased prevalence of stroke in children with brain tumors was documented (1.3%). The occurrence of stroke in children with brain tumors is potentiated by cranial radiation therapy. We are currently following a cohort of 103 adult survivors of childhood primary central nervous system tumors in our neurooncology c...
Source: Pediatric Neurology - December 6, 2013 Category: Neurology Authors: João Passos, Hipólito Nzwalo, Joana Marques, Ana Azevedo, Sofia Nunes, Duarte Salgado Tags: Letters to the Editor Source Type: research

Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery
Abstract Improved stroke care has resulted in greater survival, but >50 % of patients have chronic disabilities and 33 % are institutionalized. While stroke rehabilitation is helpful, recovery is limited and the most significant gains occur in the first 2–3 months. Stroke triggers an early wave of gene and protein changes, many of which are potentially beneficial for recovery. It is likely that these molecular changes are what subserve spontaneous recovery. Two interventions, aerobic exercise and environmental enrichment, have pleiotropic actions that influence many of the same molecular changes associated...
Source: Neurotherapeutics - February 11, 2016 Category: Neurology Source Type: research

Fatal Embolic Stroke Due to Non-Atherothrombotic Mobile Thrombi in the Carotid Artery during Gastric Cancer Chemotherapy: An Autopsy Case Report (P01.255)
CONCLUSIONS: Multiple etiologies for ischemic stroke may exist in cancer patients. A mobile thrombus in the carotid artery should be considered as a possible mechanism for arteriogenic stroke in the clinical settings of malignancy with hypercoagulability. Doppler ultrasonography is the most practical tool to identify these conditions.Disclosure: Dr. Yamada has nothing to disclose. Dr. Yoneda has nothing to disclose. Dr. Arakawa has nothing to disclose. Dr. Adachi has nothing to disclose. Dr. Gotoh has nothing to disclose. Dr. Takagi has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Yamada, A., Yoneda, J., Arakawa, C., Adachi, T., Gotoh, J., Takagi, M. Tags: P01 Cerebrovascular Disease I Source Type: research

Combination stroke therapy in the mouse with blood-brain barrier penetrating IgG-GDNF and IgG-TNF decoy receptor fusion proteins.
In conclusion, combination treatment with BBB penetrating IgG-GDNF and IgG-TNFR fusion proteins enhances the therapeutic effect of single treatment with the IgG-GDNF fusion protein following delayed intravenous administration in acute stroke. PMID: 23428543 [PubMed - as supplied by publisher]
Source: Brain Research - February 18, 2013 Category: Neurology Authors: Sumbria RK, Boado RJ, Pardridge WM Tags: Brain Res Source Type: research

Mesenchymal stem cell ‐based treatments for stroke, neural trauma, and heat stroke
ConclusionThis review offers a testable platform for targeting microglial‐mediated cytokines in clinical trials based upon the rational design of MSC therapy in the future. MSCs that are derived from the placenta provide a great choice for stem cell therapy. Although targeting the microglial activation is an important approach to reduce the burden of the injury, it is not the only one. This review focuses on this specific aspect. Ischemic stroke, neural trauma, and heatstroke all cause cerebral ischemia‐related deficits. Exogenous MSC therapy is promising as a means of augmenting brain ischemia‐induced deficits. MSC...
Source: Brain and Behavior - August 2, 2016 Category: Neurology Authors: Yogi Chang ‐Yo Hsuan, Cheng‐Hsien Lin, Ching‐Ping Chang, Mao‐Tsun Lin Tags: Review Source Type: research

D-dimer > 2.785  μg/ml and multiple infarcts ≥3 vascular territories are two characteristics of identifying cancer-associated ischemic stroke patients.
CONCLUSIONS: D-dimer >2.785 μg/ml may be an effective cutoff value and a sensitive index for identifying CAIS patients. AMBIs in ≥3 vascular territories and AMBIs in both the anterior and posterior circulations are two imaging characteristics of CAIS. PMID: 30317943 [PubMed - in process]
Source: Neurological Research - October 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J Abstract The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive review of extra-virgin olive oil. The benefits of consumption of long-chain ω-3 fatty acids are described. Fresh fish provides eicosapentaenoic acid while α-linolenic acid is found in canola and soybean oils, purslane and nuts. These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic...
Source: Revue Neurologique - September 16, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Pharmacological hypothermia induced neurovascular protection after severe stroke of transient middle cerebral artery occlusion in mice.
Abstract Therapeutic hypothermia is a potential protective strategy after stroke. The present study evaluated the neurovascular protective potential of pharmacological hypothermia induced by the neurotensin receptor 1 agonist HPI-201 after severe ischemic stroke. Adult C57BL/6 mice were subjected to filament insertion-induced occlusion of the middle cerebral artery (60 min MCAO). HPI-201 was i.p. injected 120 min after the onset of MCAO to initiate and maintain the body temperature at 32-33°C for 6 hrs. The infarct volume, cell death, integrity of the blood brain barrier (BBB) and neurovascular unit (NVU), inflam...
Source: Experimental Neurology - November 22, 2019 Category: Neurology Authors: Zhao Y, Wei ZZ, Lee JH, Gu X, Sun J, Dix TA, Wei L, Yu SP Tags: Exp Neurol Source Type: research

A Case of Perioperative Stroke Caused by Tumour Embolus. (P6.244)
CONCLUSIONS: Tumour embolism has previously been described with primary and secondary lung neoplasms, as well as cardiac tumours. Although rare, this should be considered as a potential cause of perioperative stroke in patients after cancer surgery.Study Supported by: Non-applicable.Disclosure: Dr. Hughes has nothing to disclose. Dr. Hunter has nothing to disclose. Dr. Campbell has nothing to disclose. Dr. Brady has nothing to disclose. Dr. Herron has nothing to disclose. Dr. Smyth has nothing to disclose. Dr. Rennie has nothing to disclose. Dr. Hunt has received personal compensation for activities with Eisai Inc., UCB Ph...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Hughes, S., Hunter, A., Campbell, J., Brady, A., Herron, B., Smyth, G., Rennie, I., Hunt, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Inhibition of miR-141-3p Ameliorates the Negative Effects of Poststroke Social Isolation in Aged Mice Basic Sciences
Conclusions—miR-141-3p is increased with poststroke isolation. Inhibition of miR-141-3p improved mortality, neurological deficits, and decreased infarct volumes. Importantly, these therapeutic effects occurred in aged animals, the population most at risk for stroke and poststroke isolation.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Rajkumar Verma, Rodney M. Ritzel, Nia M. Harris, Juneyoung Lee, TaeHee Kim, Gopal Pandi, Raghu Vemuganti, Louise D. McCullough Tags: Basic Science Research, Ischemia, Translational Studies Original Contributions Source Type: research