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Cancer: Chronic Leukemia

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Total 284 results found since Jan 2013.

Chronic lymphocytic leukemia of the oropharyngeal cavity and paranasal sinuses: a case series and literature review
ConclusionThe results of our study indicate that CLL infiltrates the oropharynx or paranasal sinuses in less than 1% of CLL cases. Although there seems to be no age bias between invasion in the oropharynx and the paranasal sinuses, there is a trend whereby women appear more likely to experience invasion of the paranasal sinuses.
Source: International Forum of Allergy and Rhinology - June 1, 2015 Category: Allergy & Immunology Authors: Myles F. Melton, Aaron N. Pearlman Tags: ORIGINAL ARTICLE Source Type: research

Eosinophilia in Hematologic Disorders
Eosinophilia in the peripheral blood can be the manifestation various medical conditions, including benign or malignant disorders. There are 3 main types of eosinophilia-associated myeloid neoplasms (MN-eos): myeloid and lymphoid neoplasms, chronic eosinophilic leukemia not otherwise specified, and idiopathic hypereosinophilic syndrome (HES). Imatinib mesylate has revolutionized the treatment of molecularly defined MN-eos, and novel agents have been successfully used to treat HES. The discovery of new, recurrent molecular alterations in patients with MN-eos may improve their diagnosis and therapy. This review focuses on th...
Source: Immunology and Allergy Clinics of North America - July 23, 2015 Category: Allergy & Immunology Authors: Lorenzo Falchi, Srdan Verstovsek Source Type: research

Melanoma twice as likely after CLL/SLL than other types of NHL
Survivors of chronic lymphocytic leukemia/small lymphocytic lymphoma are twice as likely to develop melanoma as are survivors of other types of non-Hodgkin lymphoma, according to a report published online Aug. 3 in Journal of Clinical Oncology. Since patients with chronic lymphocytic...googletag.display('div-gpt-ad-cta');
Source: Skin and Allergy News - August 3, 2015 Category: Dermatology Source Type: news

Chronic neutrophilic leukaemia
(CNL) is a rare type of myeloproliferative neoplasm (MPN) characterised by sustained leucocytosis (≥25x109/L) with neoplastic proliferation of neutrophilic granulocytes in blood and bone marrow. In contrast to chronic myeloid leukaemia, the disease primarily involves neutrophilic lineage with persistent proliferation of mature forms of neutrophils. No consistent cytogenetic changes have been reported. Known recurrent genetic changes in other MPNs such as JAK2, MPL, CALR, BCR-ABL1, PDGFRA, PDGFRB and FGFR1 are mostly absent. Recently, mutations in colony stimulating factor 3 receptor (CSF3R) have been reported in high f...
Source: Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Uppal, G., Gong, J. Tags: Editor's choice, Immunology (including allergy) Review Source Type: research

Secondary antibody deficiencies
Purpose of review: Antibody deficiency can occur in the context of primary immune deficiency due to inherited genetic defects or secondary to a variety of causes. This review aims to summarize current data concerning the causes of secondary antibody deficiency and where possible evidence regarding the use of prophylactic replacement immunoglobulin. Recent findings: Advances in immune-mediated therapies ranging from monoclonal antibodies to novel B-cell-targeted therapeutics are responsible for an expansion in the possible iatrogenic causes of antibody deficiency. Summary: Causes of secondary antibody deficiency include B-...
Source: Current Opinion in Allergy and Clinical Immunology - October 31, 2015 Category: Allergy & Immunology Tags: PRIMARY IMMUNE DEFICIENCY DISEASE: Edited by Bruce D. Mazer and Stephen Jolles Source Type: research

Variant of PBX2 gene in the 6p21.3 asthma susceptibility locus is associated with allergic rhinitis in Chinese subjects
ConclusionThese results suggest that the PBX2 gene in the 6p21.3 asthma susceptibility locus may be associated with increased risk for both AR and asthma in Chinese subjects.
Source: International Forum of Allergy and Rhinology - February 8, 2016 Category: Allergy & Immunology Authors: Yali Zhao, Yuan Zhang, Luo Zhang Tags: ORIGINAL ARTICLE Source Type: research

Environmental Pollution: An Under-recognized Threat to Children’s Health, Especially in Low- and Middle-Income Countries
Conclusions Patterns of disease are changing rapidly in LMICs. Pollution-related chronic diseases are becoming more common. This shift presents a particular problem for children, who are proportionately more heavily exposed than are adults to environmental pollutants and for whom these exposures are especially dangerous. Better quantification of environmental exposures and stepped-up efforts to understand how to prevent exposures that cause disease are needed in LMICs and around the globe. To confront the global problem of disease caused by pollution, improved programs of public health monitoring and environmental protecti...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Brief Communication March 2016 Source Type: research

Gene Therapy for the Treatment of Primary Immune Deficiencies
Abstract The use of gene therapy in the treatment of primary immune deficiencies (PID) has advanced significantly in the last decade. Clinical trials for X-linked severe combined immunodeficiency, adenosine deaminase deficiency (ADA), chronic granulomatous disease, and Wiskott-Aldrich syndrome have demonstrated that gene transfer into hematopoietic stem cells and autologous transplant can result in clinical improvement and is curative for many patients. Unfortunately, early clinical trials were complicated by vector-related insertional mutagenic events for several diseases with the exception of ADA-deficiency SCI...
Source: Current Allergy and Asthma Reports - April 6, 2016 Category: Allergy & Immunology Source Type: research

TGF{alpha} expression in myeloid malignancies
Conclusions TGFα is expressed in neoplastic myeloblasts and could, therefore, be used as blast cell biomarker in diagnostic haematopathology. In addition, TGFα immunohistochemistry may be of use in identifying a therapeutic target.
Source: Journal of Clinical Pathology - May 18, 2016 Category: Pathology Authors: Kavanagh, S., Mirzai, B., Fuller, K., Erber, W. N. Tags: Open access, Immunology (including allergy) Short report Source Type: research

Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies
Abstract Due to the increase in utilization of chemotherapies and antibodies, drug hypersensitivity reactions have increased dramatically worldwide, preventing the use of first-line therapies and impacting patients’ survival and quality of life. Some of the more frequently used medications in cancer include taxanes for ovarian, lung, breast, and prostate cancers. Monoclonal antibodies are used in the treatment of neoplastic, autoimmune, and inflammatory diseases, and their clinical applications are becoming broader. Monoclonal antibody targets include CD20, HER-2, EGFR, IL-6 receptor, TNF-α, CD30, VEGF-A, IgE, ...
Source: Clinical Reviews in Allergy and Immunology - June 7, 2016 Category: Allergy & Immunology Source Type: research

Thrombocytosis and STAT5 activation in chronic myelogenous leukaemia are not associated with JAK2 V617F or calreticulin mutations
Conclusions Detection of BCR-ABL1 is critical in the distinction of ET from CML. Thrombocytosis and STAT5 activation in CML-T are not consistently associated with CALR exon 9 or JAK2 V617F mutation.
Source: Journal of Clinical Pathology - July 19, 2016 Category: Pathology Authors: Turakhia, S. K., Murugesan, G., Cotta, C. V., Theil, K. S. Tags: Molecular genetics, Immunology (including allergy) Original article Source Type: research

Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS)
Conclusions Childhood cancer survivors are at increased risk for certain types of autoimmune diseases. These findings underscore the need for prolonged follow-up of these survivors.
Source: Annals of the Rheumatic Diseases - August 9, 2016 Category: Rheumatology Authors: Holmqvist, A. S., Olsen, J. H., Mellemkjaer, L., Garwicz, S., Hjorth, L., Moëll, C., Mansson, B., Tryggvadottir, L., Hasle, H., Winther, J. F., on behalf of the ALiCCS study group Tags: Press releases, Immunology (including allergy), Renal medicine, Vascularitis, Health economics Clinical and epidemiological research Source Type: research

Imatinib reduces bone marrow fibrosis and overwhelms the adverse prognostic impact of reticulin formation in patients with chronic myeloid leukaemia
Conclusions According to our findings, MF regresses with imatinib therapy over time, and the MF grades at diagnosis do not have a negative impact on the responses to imatinib treatment. Therefore, the adverse prognostic impact of the MF among patients with CML seems to disappear in the era of the TKIs.
Source: Journal of Clinical Pathology - August 16, 2016 Category: Pathology Authors: Tanrikulu Simsek, E., Eskazan, A. E., Cengiz, M., Ar, M. C., Ekizoglu, S., Salihoglu, A., Gulturk, E., Elverdi, T., Ongoren Aydin, S., Senem Demiroz, A., Buyru, A. N., Baslar, Z., Ozbek, U., Ferhanoglu, B., Aydin, Y., Tuzuner, N., Soysal, T. Tags: Immunology (including allergy) Original article Source Type: research

The Potential Role of T Helper Cell 22 and IL-22 in Immunopathogenesis of Multiple Sclerosis
Conclusion Recent evidence shows changes in frequency and function of Th22 and its cytokine IL-22 in patients with MS, which suggests a potential relationship between Th22 cells, IL-22 levels, and the development and disease course of MS and its response to treatment. How Th22 cells and IL-22 levels affect the disease course of MS requires further elucidation. Additional studies on the immunopathogenesis of MS, specifically the roles Th22 cells and IL-22 cytokines may play in disease progression, are warranted and may lead to the development of new therapeutic strategies for treating neuro-inflammatory diseases, such as MS...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Demyelinating Disease Genetics Multiple Sclerosis Neurology Review interleukin-22 T helper 22 Source Type: research

PR1 Peptide Vaccine May Aid Leukemia Remission PR1 Peptide Vaccine May Aid Leukemia Remission
PR1 peptide vaccine may benefit many patients with myeloid leukemia, chronic myeloid leukemia and myelodysplastic syndrome, findings from an early clinical trial suggest.Reuters Health Information
Source: Medscape Allergy Headlines - November 9, 2016 Category: Allergy & Immunology Tags: Public Health & Prevention News Source Type: news