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Cancer: Chronic Leukemia

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Total 284 results found since Jan 2013.

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Homoharringtonine Inhibits Allergic Inflammations by Regulating NF- κB-miR-183-5p-BTG1 Axis
We present evidence that NF-κB-miR-183-5p-BTG1 axis can serve as target for development of anti-allergy drug.
Source: Frontiers in Pharmacology - July 6, 2020 Category: Drugs & Pharmacology Source Type: research

Oncostatin M is a FIP1L1/PDGFRA‐dependent mediator of cytokine production in chronic eosinophilic leukemia
ConclusionsWe have identified a F/P‐driven paracrine interaction between neoplastic eosinophils and stromal cells that may contribute to tissue fibrosis and accumulation of neoplastic eosinophils in CEL.
Source: Allergy - April 27, 2013 Category: Allergy & Immunology Authors: G. Hoermann, S. Cerny‐Reiterer, I. Sadovnik, L. Müllauer, M. Bilban, M. Gröger, H.‐P. Horny, A. Reiter, A. Schmitt‐Graeff, C. Mannhalter, P. Valent, M. Mayerhofer Tags: Original Article Source Type: research

Preventing breastfeeding-associated hypernatraemia: an argument for supplemental feeding
The benefits of breastfeeding are unquestionable. Breast milk provides the ideal nourishment for infant growth and development. In addition, it has numerous health benefits for both infant and mother. Breastfeeding decreases the incidence of acute infections such as otitis media, respiratory tract infections and gastroenteritis; chronic diseases such as type 1 diabetes, asthma and inflammatory bowel disease, and childhood leukaemia and lymphoma; and sudden infant death syndrome. In addition, it improves neurodevelopmental outcomes for the infant. Breastfeeding benefits the mother by improving infant-maternal bonding, facil...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2013 Category: Perinatology & Neonatology Authors: Moritz, M. L. Tags: Infection (gastroenterology), Oncology, Immunology (including allergy), Foodborne infections, Otitis, TB and other respiratory infections, Coma and raised intracranial pressure, Epilepsy and seizures, Childhood nutrition, Contraception, Family planning, R Source Type: research

Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis
Source: Journal of Allergy and Clinical Immunology - March 25, 2014 Category: Allergy & Immunology Authors: Heiko Sic, Helene Kraus, Josef Madl, Karl-Andreas Flittner, Audrey Lilly von Münchow, Kathrin Pieper, Marta Rizzi, Anne-Kathrin Kienzler, Korcan Ayata, Sebastian Rauer, Burkhard Kleuser, Ulrich Salzer, Meike Burger, Katja Zirlik, Vassilios Lougaris, Ales Source Type: research

The () signalosome complex: Stepping into the limelight of human primary immunodeficiency
Next-generation DNA sequencing has accelerated the genetic characterization of many human primary immunodeficiency diseases (PIDs). These discoveries can be lifesaving for the affected patients and also provide a unique opportunity to study the effect of specific genes on human immune function. In the past 18 months, a number of independent groups have begun to define novel PIDs caused by defects in the caspase recruitment domain family, member 11 (CARD11)–B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10)–mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1 [CBM]) signalosome complex.
Source: Journal of Allergy and Clinical Immunology - July 31, 2014 Category: Allergy & Immunology Authors: Stuart E. Turvey, Anne Durandy, Alain Fischer, Shan-Yu Fung, Raif S. Geha, Andreas Gewies, Thomas Giese, Johann Greil, Bärbel Keller, Margaret L. McKinnon, Bénédicte Neven, Jacob Rozmus, Jürgen Ruland, Andrew L. Snow, Polina Stepensky, Klaus Warnatz Tags: Current perspectives Source Type: research

Medical History, Lifestyle, Family History, and Occupational Risk Factors for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes Project
Conclusions We have identified or confirmed several independent risk factors for CLL/SLL supporting a role for genetics (through family history), immune function (through allergy and sun), infection (through hepatitis C virus), and height, and other pathways of immune response. Given that CLL/SLL has more than 30 susceptibility loci identified to date, studies evaluating the interaction among genetic and nongenetic factors are warranted.
Source: JNCI Monographs - August 30, 2014 Category: Cancer & Oncology Authors: Slager, S. L., Benavente, Y., Blair, A., Vermeulen, R., Cerhan, J. R., Costantini, A. S., Monnereau, A., Nieters, A., Clavel, J., Call, T. G., Maynadie, M., Lan, Q., Clarke, C. A., Lightfoot, T., Norman, A. D., Sampson, J. N., Casabonne, D., Cocco, P., de Tags: Article Source Type: research

Cesarean Section and Chronic Immune Disorders
CONCLUSIONS: Cesarean delivery exemplifies a shared environmental risk factor in early life associating with several chronic immune diseases. Understanding commonalities in the underlying mechanisms behind chronic diseases may give novel insight into their origin and allow prevention.
Source: PEDIATRICS - January 1, 2015 Category: Pediatrics Authors: Sevelsted, A., Stokholm, J., Bonnelykke, K., Bisgaard, H. Tags: Coding Corner Article Source Type: research

GATA2 deficiency
Purpose of reviewGATA2 deficiency is a germline disease that causes a wide spectrum of phenotypes including viral and bacterial infections, cytopenias, myelodysplasia, myeloid leukemias, pulmonary alveolar proteinosis and lymphedema. The age of clinical presentation ranges from early childhood to late adulthood, with most occurring in adolescence to early adulthood. We review the expanding GATA2-deficient phenotype, molecular genetics of disease and developments in treatment. Recent findingsGATA2 mutations have been found in up to 10% of those with congenital neutropenia and/or aplastic anemia. Heterozygous mutations appea...
Source: Current Opinion in Allergy and Clinical Immunology - January 4, 2015 Category: Allergy & Immunology Tags: SPECIAL COMMENTARY: Ramsay L. Fuleihan and Bruce D. Mazer Source Type: research

Chronic lymphocytic lymphoma presenting with recurrent demodicidosis
Demodex folliculorum is a common obligatory human ectoparasite commonly seen in areas of high sebum production that does not commonly present with clinical symptoms in the immunocompetent patient. Demodicidosis presents clinically as a rosacea-like rash when a high density of Demodex mites are present in the pilosebaceous glands. This clinical manifestation of Demodex folliculorum has been associated with primary, acquired, and malignant immunocompromised states. Although most commonly reported in patients with AIDS and pediatric patients with leukemia, it is not often seen in adults with chronic lymphocytic leukemia as th...
Source: Annals of Allergy, Asthma and Immunology - February 21, 2015 Category: Allergy & Immunology Authors: Monica Sandhu, Devi Jhaveri, Haig Tcheurekdjian, Robert W. Hostoffer Tags: Letter Source Type: research

Children’s Health in Latin America: The Influence of Environmental Exposures
Conclusions: To control environmental threats to children’s health in Latin America, WHO, including PAHO, will focus on the most highly prevalent and serious hazards—indoor and outdoor air pollution, water pollution, and toxic chemicals. Strategies for controlling these hazards include developing tracking data on regional trends in children’s environmental health (CEH), building a network of Collaborating Centres, promoting biomedical research in CEH, building regional capacity, supporting development of evidence-based prevention policies, studying the economic costs of chronic diseases in children, and developing pl...
Source: EHP Research - March 2, 2015 Category: Environmental Health Authors: Web Admin Tags: Review March 2015 Source Type: research

Identification of Microcystis aeruginosa Peptides Responsible for Allergic Sensitization and Characterization of Functional Interactions between Cyanobacterial Toxins and Immunogenic Peptides
Conclusions: Phycobiliprotein complexes in M. aeruginosa have been identified as the relevant sensitizing proteins. Our finding that allergenicity is inhibited in a dose-dependent manner by microcystin toxin suggests that further investigation is warranted to understand the interplay between immunogenicity and toxicity of cyanobacteria under diverse environmental conditions. This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedit...
Source: EHP Research - April 22, 2015 Category: Environmental Health Authors: Sam Duvall Tags: Research Article Source Type: research

Advances in basic and clinical immunology in 2014
Genetic identification of immunodeficiency syndromes has become more efficient with the availability of whole-exome sequencing, expediting the identification of relevant genes and complementing traditional linkage analysis and homozygosity mapping. New genes defects causing immunodeficiency include phophoglucomutase 3 (PGM3), cytidine 5′ triphosphate synthase 1 (CTPS1), nuclear factor κB–inducing kinase (NIK), cytotoxic T lymphocyte–associated antigen 4 (CTLA4), B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10), phosphoinositide-3 kinase regulatory subunit 1 (PIK3R1), IL21, and Jagunal homolog 1 (JAGN1).
Source: Journal of Allergy and Clinical Immunology - May 1, 2015 Category: Allergy & Immunology Authors: Javier Chinen, Luigi D. Notarangelo, William T. Shearer Tags: Reviews and feature article Source Type: research

LEF1: a highly specific marker for the diagnosis of chronic lymphocytic B cell leukaemia/small lymphocytic B cell lymphoma
Conclusions LEF1 is a useful marker in the differential diagnosis of CLL in difficult cases. It shows a high specificity (92%) and a reasonable sensitivity (70%) for this entity.
Source: Journal of Clinical Pathology - May 18, 2015 Category: Pathology Authors: Menter, T., Dirnhofer, S., Tzankov, A. Tags: Immunology (including allergy), Breast cancer Original article Source Type: research