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Total 468 results found since Jan 2013.

Primary Prevention of Cardiovascular Disease in Older Adults
Publication date: Available online 22 April 2016 Source:Canadian Journal of Cardiology Author(s): Arden R. Barry, Deirdre E. O'Neill, Michelle M. Graham Primary prevention of cardiovascular events in older adults is challenging because of a general paucity of evidence for safe and efficacious therapy. Furthermore, there is no validated cardiovascular risk assessment tool for older adults (≥75 years of age), yet most are intermediate-to high-risk. Assessment of cardiovascular risk should include a discussion of the potential benefits and risks of therapy, and allow for incorporation of the patients' values and prefer...
Source: Canadian Journal of Cardiology - April 27, 2016 Category: Cardiology Source Type: research

Evolving Treatments for Arterial and Venous Thrombosis: Role of the Direct Oral Anticoagulants.
Abstract The direct oral anticoagulants (DOACs) represent a major advance in oral anticoagulant therapy and have replaced the vitamin K antagonists as the preferred treatment for many indications. By simplifying long-term anticoagulant therapy and improving its safety, the DOACs have the potential to reduce the global burden of thrombosis. Postmarketing studies suggest that the favorable results achieved with DOACs in the randomized controlled trials can be readily translated into practice, but highlight the need for appropriate patient, drug and dose selection, and careful follow-up. Leveraging on their success t...
Source: Circulation Research - April 28, 2016 Category: Cardiology Authors: Chan NC, Eikelboom JW, Weitz JI Tags: Circ Res Source Type: research

Utility of Global Longitudinal Strain by Echocardiography to Detect Left Ventricular Dysfunction in Long-Term Adult Survivors of Childhood Lymphoma and Acute Lymphoblastic Leukemia
Measuring left ventricular (LV) global longitudinal strain (GLS) is recommended in screening of long-term cancer survivors for cardiotoxicity. However, there are limited data on GLS in this setting, in particular in survivors with apparently normal LV function without risk factors of impaired GLS. In the present study, we measured GLS in 191 adult survivors of childhood lymphoma or acute lymphoblastic leukemia, with normal LV ejection fraction (EF) and fractional shortening (FS), and without known hypertension, diabetes mellitus, myocardial infarction or stroke.
Source: The American Journal of Cardiology - May 13, 2016 Category: Cardiology Authors: Jon R. Christiansen, Richard Massey, Håvard Dalen, Adriani Kanellopoulos, Hanne Hamre, Sophie D. Fosså, Ellen Ruud, Cecilie E. Kiserud, Svend Aakhus Source Type: research

Pharmacologic Approaches to Weight Management: Recent Gains and Shortfalls in Combating Obesity
This article reviews recent literature in the field of Obesity Medicine and highlights important findings from clinical trials. Future directions in the pharmacologic management of obesity are presented along with new diabetes medications that promote weight loss and reduce cardiovascular mortality.
Source: Current Atherosclerosis Reports - May 14, 2016 Category: Cardiology Source Type: research

Exercise and Aerobic Fitness to Reduce Cancer-Related Cardiovascular Toxicity
Opinion statement Several cancer treatments are associated with vascular toxicity, mainly mediated by their effects on endothelial cell function. In turn, vascular dysfunction may contribute to cardiac damage and other cardiovascular side effects such as hypertension, stroke, and arterial and venous thrombosis. Aerobic exercise is associated with numerous beneficial effects on the endothelium and on cardiovascular risk factors, and may potentially modulate some of the mechanisms of vascular damage associated with antineoplastic therapies, thereby reducing their cardiovascular toxicity. To date, only a very limite...
Source: Current Treatment Options in Cardiovascular Medicine - May 15, 2016 Category: Cardiology Source Type: research

Carotid artery stenting
Learning objectives After reading this article the reader should:Know the appropriate diagnostic workup for patients with carotid artery disease. Be able to put in perspective, based on strengths and limitations, the results of randomised trials comparing carotid artery stenting and carotid endarterectomy. Be able to identify patients that may benefit from carotid artery stenting. Introduction In western countries, stroke is the fourth leading cause of death, after heart disease, cancer and chronic respiratory diseases.1 Carotid artery disease may be responsible for 10–15% of all ischaemic strokes.2 Randomised contro...
Source: Heart - June 9, 2016 Category: Cardiology Authors: Roffi, M., Kulcsar, Z., Carrera, E., Cremonesi, A. Tags: Education in Heart, Drugs: cardiovascular system, Interventional cardiology, Epidemiology, Tobacco use Source Type: research

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study Kidney in Cardiovascular Disease
Conclusions Even mildly reduced eGFR (under 90 mL/min per 1.73 m2) is associated with elevated 10-year Framingham risk for CHD and 10-year ASCVD risk among Chinese adults.
Source: JAHA:Journal of the American Heart Association - July 21, 2016 Category: Cardiology Authors: Lu, J., Mu, Y., Su, Q., Shi, L., Liu, C., Zhao, J., Chen, L., Li, Q., Yang, T., Yan, L., Wan, Q., Wu, S., Liu, Y., Wang, G., Luo, Z., Tang, X., Chen, G., Huo, Y., Gao, Z., Ye, Z., Wang, Y., Qin, G., Deng, H., Yu, X., Shen, F., Chen, L., Zhao, L., Sun, J., Tags: Cardiovascular Disease, Epidemiology, Lifestyle, Risk Factors Kidney in Cardiovascular Disease Source Type: research

Utility of Global Longitudinal Strain by Echocardiography to Detect Left Ventricular Dysfunction in Long-Term Adult Survivors of Childhood Lymphoma and Acute Lymphoblastic Leukemia
Measuring left ventricular (LV) global longitudinal strain (GLS) is recommended in screening of long-term cancer survivors for cardiotoxicity. However, there are limited data on GLS in this setting, in particular in survivors with apparently normal LV function without risk factors of impaired GLS. In the present study, we measured GLS in 191 adult survivors of childhood lymphoma or acute lymphoblastic leukemia, with normal LV ejection fraction and fractional shortening (FS) and without known hypertension, diabetes mellitus, myocardial infarction, or stroke.
Source: The American Journal of Cardiology - May 13, 2016 Category: Cardiology Authors: Jon R. Christiansen, Richard Massey, H åvard Dalen, Adriani Kanellopoulos, Hanne Hamre, Sophie D. Fosså, Ellen Ruud, Cecilie E. Kiserud, Svend Aakhus Tags: Cardiomyopathy Source Type: research

Return to the Workforce Following First Hospitalization for Heart Failure: A Danish Nationwide Cohort Study.
CONCLUSIONS: -Patients in the workforce prior to HF hospitalization had low mortality but high risk of detachment from the workforce one year later. Young age, male sex, and higher level of education were predictors of return to work. PMID: 27507406 [PubMed - as supplied by publisher]
Source: Circulation - August 8, 2016 Category: Cardiology Authors: Rørth R, Wong C, Kragholm K, Fosbøl E, Mogensen UM, Lamberts M, Petrie MC, Jhund PS, Gerds TA, Torp-Pedersen C, Gislason GH, McMurray JJ, Køber L, Kristensen SL Tags: Circulation Source Type: research

Bowel movement frequency and cardiovascular mortality, a matter of fibers and oxidative stress?
To the Editor, Hippocrates, the father of western medicine, believed that all disease begins in the gut. Today, the global obesity epidemic, resulting in serious diet-related diseases, including cardiovascular disease, stroke, hypertension, diabetes mellitus type 2 and certain forms of cancer, including colorectal cancer, reveals that his view is still relevant. The relation between diet and health and the resulting potential for disease prevention has increasingly been emphasized in health promotion messages over the last thirty years [1 –5].
Source: Atherosclerosis - August 20, 2016 Category: Cardiology Authors: Alphons J.M. Vermorken, Yali Cui, Robbert Kleerebezem, Emmanuel Andr ès Tags: Correspondence Source Type: research

Added Sugars and Cardiovascular Disease Risk in Children: A Scientific Statement From the American Heart Association.
CONCLUSIONS: Associations between added sugars and increased cardiovascular disease risk factors among US children are present at levels far below current consumption levels. Strong evidence supports the association of added sugars with increased cardiovascular disease risk in children through increased energy intake, increased adiposity, and dyslipidemia. The committee found that it is reasonable to recommend that children consume ≤25 g (100 cal or ≈6 teaspoons) of added sugars per day and to avoid added sugars for children <2 years of age. Although added sugars most likely can be safely consumed in low amounts as ...
Source: Circulation - August 21, 2016 Category: Cardiology Authors: Vos MB, Kaar JL, Welsh JA, Van Horn LV, Feig DI, Anderson CA, Patel MJ, Cruz Munos J, Krebs NF, Xanthakos SA, Johnson RK, American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Clinical Cardiology Tags: Circulation Source Type: research

Cancer-related multiple brain infarctions caused by Trousseau syndrome in a patient with metastatic colon cancer: a case report.
Abstract Thromboembolism that occurs in association with a malignant tumor is known as Trousseau syndrome. We herein present a case of Trousseau syndrome during systemic chemotherapy for metastatic colon cancer. A 65-year-old man with multiple liver metastases underwent primary tumor resection and systemic chemotherapy. Multiple brain infarctions were detected by magnetic resonance imaging immediately after first-line chemotherapy, which was deemed ineffective. There was no evidence of cardioembolic stroke or carotid atherosclerosis. Although the patient was initially asymptomatic, he subsequently developed paraly...
Source: Atherosclerosis - September 8, 2016 Category: Cardiology Authors: Akiyama T, Miyamoto Y, Sakamoto Y, Tokunaga R, Kosumi K, Shigaki H, Kurashige J, Iwatsuki M, Baba Y, Yoshida N, Baba H Tags: Surg Case Rep Source Type: research

Rivaroxaban for Periprocedural Anticoagulation Therapy in Japanese Patients Undergoing Catheter Ablation of Paroxysmal Non-Valvular Atrial Fibrillation.
This study aimed to investigate the safety and feasibility of periprocedural anticoagulation therapy with rivaroxaban in Japanese patients undergoing paroxysmal non-valvular AF (NVAF) ablation using radiofrequency energy.This study was a multicenter, prospective pilot study. In paroxysmal NVAF patients, rivaroxaban (15 mg or 10 mg once-daily) was started at least 4 weeks prior to AF ablation, discontinued on the day of the procedure, resumed within 24 hours after ablation, and continued at least 3 months afterwards. During the interruption of rivaroxaban, bridging anticoagulation therapy with unfractionated heparin was giv...
Source: International Heart Journal - November 9, 2016 Category: Cardiology Tags: Int Heart J Source Type: research

Resting Heart Rate Trajectory Pattern Predicts Arterial Stiffness in a Community-Based Chinese Cohort.
CONCLUSIONS: Long-term RHR pattern is a strong predictor of having arterial stiffness. PMID: 27908892 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 30, 2016 Category: Cardiology Authors: Chen S, Li W, Jin C, Vaidya A, Gao J, Yang H, Wu S, Gao X Tags: Arterioscler Thromb Vasc Biol Source Type: research

The Role of the Private Sector in Tilting Health Systems Toward Chronic Disease Prevention
Over the last century, the global disease burden has undergone a dramatic transformation. Noncommunicable diseases (NCD) —including heart disease, stroke, cancer, chronic respiratory diseases, and diabetes—are now the leading cause of mortality in the world, accounting for 60% of all deaths globally. Although this shift is partially attributable to medical and public health advances addressing infectious diseases in the 20th century, many developing countries face the double burden of persisting communicable disease and rising NCD.
Source: CVD Prevention and Control - November 30, 2016 Category: Cardiology Authors: Sarah Kunkle, Gillian Christie, Cother Hajat, Derek Yach Tags: Viewpoint Source Type: research