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Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Urinary cadmium and stroke - a case-cohort study in Danish never-smokers
CONCLUSIONS: Our results do not support that low levels of cadmium exposure among never-smokers are strongly associated with risk of stroke, although results varied somewhat by sex and method of accounting for urinary dilution.PMID:34062200 | DOI:10.1016/j.envres.2021.111394
Source: Environmental Research - June 1, 2021 Category: Environmental Health Authors: Aslak Harbo Poulsen Clara G Sears James Harrington Chanelle J Howe Katherine A James Nina Roswall Kim Overvad Anne Tj ønneland Gregory A Wellenius Jaymie Meliker Ole Raaschou-Nielsen Source Type: research

An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial.
CONCLUSIONS: This large phase III study provided no evidence of benefit for the provision of a routine occupational therapy service, including staff training, for care home residents living with stroke related disabilities. The established three month individualised course of occupational therapy targeting stroke related disabilities did not have an impact on measures of functional activity, mobility, mood, or health related quality of life, at all observational time points. Providing and targeting ameliorative care in this clinically complex population requires alternative strategies.Trial registration Current Controlled ...
Source: Cancer Control - February 8, 2015 Category: Cancer & Oncology Authors: Sackley CM, Walker MF, Burton CR, Watkins CL, Mant J, Roalfe AK, Wheatley K, Sheehan B, Sharp L, Stant KE, Fletcher-Smith J, Steel K, Wilde K, Irvine L, Peryer G, OTCH trial investigators Tags: BMJ Source Type: research

Fruit and vegetable consumption is associated with reduced all-cause and cardiovascular mortality
Commentary on: Wang X, Ouyang Y, Liu J, et al.. Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. BMJ 2014;349:g4490 Context Dietary guidelines from around the world recommend the daily consumption of a variety of fruits and vegetables. For example, the ‘5 a day’ public health campaign in the UK encourages people to consume at least five 80 g portions of fruits and vegetables every day. These guidelines are largely based on recommendations from the WHO to consume at least 400&nb...
Source: Evidence-Based Medicine - January 21, 2015 Category: Internal Medicine Authors: Crowe, F. L. Tags: Smoking and tobacco, Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, Diet, Ischaemic heart disease, Health education, Smoking Therapeutics/Prevention Source Type: research

Long-term Fine Particulate Matter Exposure and Nonaccidental and Cause-specific Mortality in a Large National Cohort of Chinese Men
Conclusions: Long-term exposure to PM2.5 was associated with nonaccidental, CVD, lung cancer, and COPD mortality in China. The IER estimator may underestimate the excess relative risk of cause-specific mortality due to long-term exposure to PM2.5 over the exposure range experienced in China and other low- and middle-income countries. https://doi.org/10.1289/EHP1673 Received: 24 February 2017 Revised: 01 September 2017 Accepted: 05 September 2017 Published: 07 November 2017 Address correspondence to M. Zhou, National Center for Chronic Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control ...
Source: EHP Research - November 7, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Modifiable Lifestyle Factors and Cognitive Function in Older People: A Cross-Sectional Observational Study
Conclusions: Lifestyle factors, such as physical activity, sleep, and social activity appear to be associated with cognitive function among older people. Physical activity and appropriate durations of sleep and conversation are important for cognitive function. Introduction Dementia is a major public health issue worldwide, with a serious burden for patients, caregivers, and society, as well as substantial economic impacts (1). Although the prevalence of late-life cognitive impairment and dementia are expected to increase in future, effective disease-modifying treatments are currently unavailable. Therefore, unders...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Long-Term Exposure to Road Traffic Noise and Nitrogen Dioxide and Risk of Heart Failure: A Cohort Study
Conclusions: Long-term exposure to NO2 and road traffic noise was associated with higher risk of heart failure, mainly among men, in both single- and two-pollutant models. High exposure to both pollutants was associated with highest risk. https://doi.org/10.1289/EHP1272 Received: 25 October 2016 Revised: 09 August 2017 Accepted: 09 August 2017 Published: 26 September 2017 Address correspondence to M. Sørensen. Diet, Genes and Environment, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark. Telephone: +45 35257626. Email: mettes@cancer.dk Supplemental Material is available online (https://doi.org/1...
Source: EHP Research - September 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Analysis of health service amenable and non-amenable mortality before and since China's expansion of health coverage in 2009
Conclusions Although there was no clear evidence of an early impact of China's health reform on mortality, this does not rule out potentially important contributions to reducing the burden of disease in the longer term.
Source: BMJ Open - January 5, 2016 Category: Journals (General) Authors: Feng, X., Liu, Y., Astell-Burt, T., Yin, P., Page, A., Liu, S., Liu, J., Wang, L., Zhou, M. Tags: Open access, Epidemiology, Public health Research Source Type: research

Does coffee make you live longer?
Conclusion This study, conducted on a large number of people across Europe, was backed up by similar findings in the US. It appears to show some association between people who drink higher amounts of coffee and a reduced risk of death. But the "potentially beneficial clinical implications" need to be considered carefully for a number of reasons: Although the analyses were adjusted for some confounding variables, there may be a number of other factors that differ between the groups that account for the differences in death, such as socioeconomic status, family history, other medical conditions, and use of medic...
Source: NHS News Feed - July 12, 2017 Category: Consumer Health News Tags: Food/diet Source Type: news

Sociodemographic, psychiatric and somatic risk factors for suicide: a Swedish national cohort study.
CONCLUSIONS: All psychiatric disorders, COPD, cancer, spine disorders, asthma, stroke, diabetes, ischemic heart disease and specific sociodemographic factors were independent risk factors for suicide during 8 years of follow-up. Effective prevention of suicide requires a multifaceted approach in both psychiatric and primary care settings, targeting mental disorders (especially depression), specific somatic disorders and indicators of social support. PMID: 23611178 [PubMed - as supplied by publisher]
Source: Psychological Medicine - April 23, 2013 Category: Psychiatry Authors: Crump C, Sundquist K, Sundquist J, Winkleby MA Tags: Psychol Med Source Type: research

This Vitamin Could Save Your Life
For years, I’ve recommended that my patients take a special family of super-nutrients with the power to boost their health and save their lives in at least a half a dozen ways. I’m talking about tocotrienols, an especially potent form of vitamin E. Tocotrienols, which comprise four out of the eight types of vitamin E, are powerful antioxidants that until recently were ignored by mainstream medicine. But the patients at my wellness clinic and regular readers of my newsletter will know that I’ve recommended them as a critical nutrient for years. And I do it because almost daily I observe the effects of the...
Source: Al Sears, MD Natural Remedies - March 26, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Anti-Aging Nutrition antioxidants brain Cancer heart heart disease nutrients supplements vitamins Source Type: news

Chronic disease prevalence in women and air pollution - A 30-year longitudinal cohort study.
CONCLUSIONS: This study estimated significant elevated prevalent rate ratios per unit increase in PM2.5 in nine of the ten chronic diseases studied. PMID: 25863281 [PubMed - as supplied by publisher]
Source: Environment International - April 6, 2015 Category: Environmental Health Authors: To T, Zhu J, Villeneuve PJ, Simatovic J, Feldman L, Gao C, Williams D, Chen H, Weichenthal S, Wall C, Miller AB Tags: Environ Int Source Type: research

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