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A Prospective Cohort Study of Prenatal Diethylstilbestrol Exposure and Cardiovascular Disease Risk.
Conclusions: These data demonstrate associations in women of prenatal DES exposure with CAD and MI, but not stroke, that appear independent of established CVD risk factors. PMID: 29069384 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 20, 2017 Category: Endocrinology Authors: Troisi R, Titus L, Hatch EE, Palmer JR, Huo D, Strohsnitter WC, Adam E, Ricker W, Hyer M, Hoover RN Tags: J Clin Endocrinol Metab Source Type: research

Prevalence and factors connected with chronic diseases in the elderly residents of Birjand: a community – based study in Birjand, South Khorasan Province, Iran
ConclusionThe findings demonstrated that hypertension, diabetes mellitus, and stroke are the three prevalent NCDs among elders in the area and warrant a specific focus on reducing the burden of diseases and aligning healthcare services to prepare the whole needs of this population.
Source: Journal of Diabetes and Metabolic Disorders - November 3, 2021 Category: Endocrinology Source Type: research

Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial
Publication date: Available online 13 September 2017 Source:The Lancet Diabetes & Endocrinology Author(s): Rury R Holman, Ruth L Coleman, Juliana C N Chan, Jean-Louis Chiasson, Huimei Feng, Junbo Ge, Hertzel C Gerstein, Richard Gray, Yong Huo, Zhihui Lang, John J McMurray, Lars Rydén, Stefan Schröder, Yihong Sun, Michael J Theodorakis, Michal Tendera, Lynne Tucker, Jaakko Tuomilehto, Yidong Wei, Wenying Yang, Duolao Wang, Dayi Hu, Changyu Pan Background The effect of the α-glucosidase inhibitor acarbose on cardiovascular outcomes in patients with coronary heart disease and impaired glucose tolerance is unknown....
Source: The Lancet Diabetes and Endocrinology - September 14, 2017 Category: Endocrinology Source Type: research

Impact of age-adjusted Insulin-like Growth Factor I on major cardiovascular events after acute myocardial infarction.
CONCLUSIONS: Low IGF-I score is associated with increased risk of all cause-death, recurrent MI and stroke in AMI patients. Whether patients treated by IGF-I axis inhibitors have a specific clinical course after AMI would be worth studying. PMID: 25699636 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 20, 2015 Category: Endocrinology Authors: Bourron O, Le Bouc Y, Berard L, Kotti S, Brunel N, Ritz B, Leclercq F, Tabone X, Drouet E, Mulak G, Danchin N, Simon T Tags: J Clin Endocrinol Metab Source Type: research

Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis
Publication date: Available online 6 December 2017 Source:The Lancet Diabetes & Endocrinology Author(s): M Angelyn Bethel, Rishi A Patel, Peter Merrill, Yuliya Lokhnygina, John B Buse, Robert J Mentz, Neha J Pagidipati, Juliana C Chan, Stephanie M Gustavson, Nayyar Iqbal, Aldo P Maggioni, Peter Öhman, Neil R Poulter, Ambady Ramachandran, Bernard Zinman, Adrian F Hernandez, Rury R Holman Background Glucagon-like peptide-1 (GLP-1) receptor agonists are effective glucose-lowering drugs. Findings from cardiovascular outcome trials showed cardiovascular safety of GLP-1 receptor agonists, but results for cardiovascular...
Source: The Lancet Diabetes and Endocrinology - December 6, 2017 Category: Endocrinology Source Type: research

Diabetes and ageing in the Melbourne Collaborative Cohort Study (MCCS)
Conclusions: Diabetes is strongly associated with factors characterising less successful ageing, suggesting that the impact of diabetes may be larger than currently estimated.
Source: Diabetes Research and Clinical Practice - April 12, 2013 Category: Endocrinology Authors: Allison M. Hodge, Leon Flicker, Kerin O’Dea, Dallas R. English, Graham G. Giles Tags: Epidemiology Source Type: research

Coffee and tea: perks for health and longevity?
Abstract PURPOSE OF REVIEW: Tea and coffee, after water, are the most commonly consumed beverages in the world and are the top sources of caffeine and antioxidant polyphenols in the American diet. The purpose of this review is to assess the health effects of chronic tea and/or coffee consumption. RECENT FINDINGS: Tea consumption, especially green tea, is associated with significantly reduced risks for stroke, diabetes and depression, and improved levels of glucose, cholesterol, abdominal obesity and blood pressure. Habitual coffee consumption in large epidemiological studies is associated with reduced mortali...
Source: Diabetes Metab - September 25, 2013 Category: Endocrinology Authors: Bhatti SK, O'Keefe JH, Lavie CJ Tags: Curr Opin Clin Nutr Metab Care Source Type: research

Risk of all-cause mortality and vascular events in women versus men with type 1 diabetes: a systematic review and meta-analysis
Publication date: Available online 6 February 2015 Source:The Lancet Diabetes & Endocrinology Author(s): Rachel R Huxley , Sanne A E Peters , Gita D Mishra , Mark Woodward Background Studies have suggested sex differences in the mortality rate associated with type 1 diabetes. We did a meta-analysis to provide reliable estimates of any sex differences in the effect of type 1 diabetes on risk of all-cause mortality and cause-specific outcomes. Methods We systematically searched PubMed for studies published between Jan 1, 1966, and Nov 26, 2014. Selected studies reported sex-specific estimates of the standardised m...
Source: The Lancet Diabetes and Endocrinology - February 6, 2015 Category: Endocrinology Source Type: research

10‐Year Observational Follow‐Up of PROactive: a randomized cardiovascular outcomes trial evaluating pioglitazone in type 2 diabetes
ConclusionsThe trends of macrovascular benefits of pioglitazone compared with placebo during PROactive did not persist in the absence of continued pioglitazone during this 10‐year follow‐up. Trends of decreased bladder cancer and increased prostate cancer were observed in the pioglitazone group during follow‐up; however, these imbalances should be interpreted with caution due to limitations of the observational study design.
Source: Diabetes, Obesity and Metabolism - November 23, 2015 Category: Endocrinology Authors: Erland Erdmann, Sarah Harding, Hung Lam, Alfonso Perez Tags: ORIGINAL ARTICLE Source Type: research

Acute Kidney Injury Predicts Major Adverse Outcomes in Diabetes: Synergic Impact With Low Glomerular Filtration Rate and Albuminuria
CONCLUSIONS AKI, low eGFR, and elevated albuminuria, separately or together, are compelling biomarkers of major adverse outcomes and death in diabetes.
Source: Diabetes Care - November 24, 2015 Category: Endocrinology Authors: Monseu, M.; Gand, E.; Saulnier, P.-J.; Ragot, S.; Piguel, X.; Zaoui, P.; Rigalleau, V.; Marechaud, R.; Roussel, R.; Hadjadj, S.; Halimi, J.-M.; for the SURDIAGENE Study Group Tags: Pathophysiology/Complications Source Type: research

Ten‐year observational follow‐up of PROactive: a randomized cardiovascular outcomes trial evaluating pioglitazone in type 2 diabetes
ConclusionsThe trends of macrovascular benefits of pioglitazone compared with placebo during PROactive did not persist in the absence of continued pioglitazone during this 10‐year follow‐up. Trends of decreased bladder cancer and increased prostate cancer were observed in the pioglitazone group during follow‐up; however, these imbalances should be interpreted with caution because of the limitations of the observational study design.
Source: Diabetes, Obesity and Metabolism - January 8, 2016 Category: Endocrinology Authors: E. Erdmann, S. Harding, H. Lam, A. Perez Tags: ORIGINAL ARTICLE Source Type: research

Socioeconomic factors relating to diabetes and its management in India / 印度与糖尿病及其治疗相关的社会经济因素
Abstract Diabetes is an escalating problem in India and has major socioeconomic dimensions. Rapid dietary changes coupled with decreased levels of physical activity have resulted in increases in obesity and diabetes in rural and semi‐urban areas, as well as in urban‐based people living in resettlement colonies. Increasing risk has also been recorded in those who suffered from poor childhood nutrition and in rural‐to‐urban migrants. Social inequity manifests in disparities in socioeconomic status (SES), place of residence, education, gender, and level of awareness and affects prevention, care, and management. All th...
Source: Journal of Diabetes - July 30, 2015 Category: Endocrinology Authors: Usha Shrivastava, Anoop Misra, Rajeev Gupta, Vijay Viswanathan Tags: Review Article Source Type: research

Cardiovascular and Other Outcomes Postintervention With Insulin Glargine and Omega-3 Fatty Acids (ORIGINALE)
CONCLUSIONS During >6 years of treatment followed by >2.5 years of observation, insulin glargine had neutral effects on health outcomes and salutary effects on metabolic control, whereas omega-3 fatty acid supplementation had no effect.
Source: Diabetes Care - April 20, 2016 Category: Endocrinology Authors: ORIGIN Trial Investigators Tags: Cardiovascular Disease and Diabetes Source Type: research

Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28 randomised trials
Publication date: Available online 29 July 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Cholesterol Treatment Trialists' (CTT) Collaboration Background Statin therapy is effective for the prevention of coronary heart disease and stroke in patients with mild-to-moderate chronic kidney disease, but its effects in individuals with more advanced disease, particularly those undergoing dialysis, are uncertain. Methods We did a meta-analysis of individual participant data from 28 trials (n=183 419), examining effects of statin-based therapy on major vascular events (major coronary event [non-fatal myoca...
Source: The Lancet Diabetes and Endocrinology - July 28, 2016 Category: Endocrinology Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

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