Trends in Factors Affecting Pregnancy Outcomes Among Women With Type 1 or Type 2 Diabetes of Childbearing Age (2004 –2017)
ConclusionsDespite significant improvements in general diabetes care, the majority of women with Type 1 or Type 2 diabetes have unfavorable, although mostly modifiable, factors for the start of pregnancy. Good diabetes care for women of childbearing age should include taking into consideration a possible pregnancy. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 22, 2021 Category: Endocrinology Source Type: research

IJERPH, Vol. 18, Pages 523: Association between Influenza Vaccine Administration and Primary Care Consultations for Respiratory Infections: Sentinel Network Study of Five Seasons (2014/2015 –2018/2019) in the UK
IJERPH, Vol. 18, Pages 523: Association between Influenza Vaccine Administration and Primary Care Consultations for Respiratory Infections: Sentinel Network Study of Five Seasons (2014/2015–2018/2019) in the UK International Journal of Environmental Research and Public Health doi: 10.3390/ijerph18020523 Authors: Vaishnavi Parimalanathan Mark Joy Pieter Jan Van Dam Xuejuan Fan Simon de Lusignan Influenza, a vaccine preventable disease, is a serious global public health concern which results in a considerable burden on the healthcare system. However, vaccine hesitancy is increasingly becoming a global probl...
Source: International Journal of Environmental Research and Public Health - January 10, 2021 Category: Environmental Health Authors: Vaishnavi Parimalanathan Mark Joy Pieter Jan Van Dam Xuejuan Fan Simon de Lusignan Tags: Article Source Type: research

Collaborate to deliver biggest ever flu vaccination programme, RPS and RCGP say
Pharmacists and GPs should work together to make sure as many people as possible get their flu vaccination this winter, the Royal Pharmaceutical Society and the Royal College of General Practitioners have said. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - September 21, 2020 Category: Drugs & Pharmacology Source Type: research

Occupational low-dose irradiation and cancer risk among medical radiation workers
ConclusionsExcess risk of cancer is suspected for high and former exposures. The more highly exposed professions, i.e. interventional physicians and nuclear medicine workers, should be monitored carefully. Collaborative projects aiming to increase the quantity and quality of information of the studied populations would be a key point (Source: Occupational Medicine)
Source: Occupational Medicine - August 5, 2020 Category: Respiratory Medicine Source Type: research

Does Renal Function or Heart Failure Diagnosis Affect Primary Care Prescribing for Sodium-Glucose Co-Transporter  2 Inhibitors in Type 2 Diabetes?
AbstractIntroductionSodium-glucose co-transporter  2 inhibitors (SGLT2is) are a unique class of drugs currently used in the management of type 2 diabetes (T2D). There are emerging data from cardiovascular outcome trials confirming renal and heart failure benefits of these drugs independent of glucose lowering. By contrast, the current licencing i ndications of these drugs are mainly limited to their glucose-lowering effects, and not to renal or heart failure benefits. It is therefore timely to ascertain whether the presence of these clinical conditions may influence prescribing choices for patients with T2D. Our aims are...
Source: Diabetes Therapy - July 14, 2020 Category: Endocrinology Source Type: research

Integrating molecular point-of-care testing for influenza into primary care: a mixed-methods feasibility study.
CONCLUSION: Testing for influenza using POCT is feasible in primary care and may improve antimicrobial use. However, further evidence from randomised trials of influenza POCT in general practice is needed. PMID: 32661013 [PubMed - as supplied by publisher] (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - July 12, 2020 Category: Primary Care Authors: de Lusignan S, Hoang U, Liyanage H, Tripathy M, Yonova I, Byford R, Ferreira F, Diez-Domingo J, Clark T Tags: Br J Gen Pract Source Type: research

Reorganisation of primary care for older adults during COVID-19: a cross-sectional database study in the UK.
CONCLUSION: Primary care has undergone an unprecedented in-pandemic reorganisation while retaining focus on patients with increased complexity. PMID: 32661009 [PubMed - as supplied by publisher] (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - July 12, 2020 Category: Primary Care Authors: Joy M, McGagh D, Jones N, Liyanage H, Sherlock J, Parimalanathan V, Akinyemi O, van Vlymen J, Howsam G, Marshall M, Hobbs FR, de Lusignan S Tags: Br J Gen Pract Source Type: research

Engagement with and delivery of the 'parkrun practice initiative' in general practice: a mixed methods study.
CONCLUSION: Practices were keen to improve patient and staff health. Addressing time constraints and staff support needs to be considered when implementing the initiative. PMID: 32482630 [PubMed - as supplied by publisher] (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - May 31, 2020 Category: Primary Care Authors: Fleming J, Bryce C, Parsons J, Wellington C, Dale J Tags: Br J Gen Pract Source Type: research

Pharmacists and doctors launch resource to support multidisciplinary teams in general practice
The Royal Pharmaceutical Society in Wales and the Royal College of General Practitioners Wales have jointly published a resource designed to help multidisciplinary teams in general practice work better together. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - February 12, 2020 Category: Drugs & Pharmacology Source Type: research

Clinical Ontologies Improve Case Finding of Primary Biliary Cholangitis in UK Primary and Secondary Care
ConclusionsUtilization of the UK National RCGP RSC database supported by novel ontology score has successfully helped us identify (i) new cases of PBC not known to local/regional secondary care providers and (ii) de novo PBC cases. There are many PBC probable cases whose data merit further careful evaluation. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 16, 2020 Category: Gastroenterology Source Type: research

Number of flu cases in general practice rises by more than 1,700 in one week
The number of flu cases has risen by 1,748 in one week, according to data collected by the Royal College of General Practitioners. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - December 24, 2019 Category: Drugs & Pharmacology Source Type: research

Seasonal influenza: Modelling approaches to capture immunity propagation
by Edward M. Hill, Stavros Petrou, Simon de Lusignan, Ivelina Yonova, Matt J. Keeling Seasonal influenza poses serious problems for global public health, being a significant contributor to morbidity and mortality. In England, there has been a long-standing national vaccination programme, with vaccination of at-risk groups and children offering partial protection against infection. Transmission models have been a fundamental component of analysis, informing the efficient use of limited resources. However, these models generally treat each season and each strain circulating within that season in isolation. Here, we amalgama...
Source: PLoS Computational Biology - October 27, 2019 Category: Biology Authors: Edward M. Hill Source Type: research

Disparities in glycaemic control, monitoring, and treatment of type 2 diabetes in England: A retrospective cohort analysis
by Martin B. Whyte, William Hinton, Andrew McGovern, Jeremy van Vlymen, Filipa Ferreira, Silvio Calderara, Julie Mount, Neil Munro, Simon de Lusignan BackgroundDisparities in type 2 diabetes (T2D) care provision and clinical outcomes have been reported in the last 2 decades in the UK. Since then, a number of initiatives have attempted to address this imbalance. The aim was to evaluate contemporary data as to whether disparities exist in glycaemic control, monitoring, and prescribing in people with T2D. Methods and findingsA T2D cohort was identified from the Royal College of General Practitioners Research and Surveillance ...
Source: PLoS Medicine - October 6, 2019 Category: Internal Medicine Authors: Martin B. Whyte Source Type: research

089 Atopic Dermatitis Is Associated With an Increased Risk of Autoimmune Diseases: A Population-Based Cohort Study Using UK Primary Care Data
Atopic dermatitis (AD) is associated with a wide range of comorbidities, particularly allergies, but its association with nonatopic autoimmune disease is less well defined. Recent genome-wide association studies have reported shared genetic loci between AD and autoimmune diseases. In the UK, most patients with these conditions are managed in primary care, meaning general practice (GP) databases provide a rich data source for studying AD. A retrospective cohort study was undertaken to examine the association between AD and the following autoimmune diseases (rheumatoid arthritis [RA], ulcerative colitis [UC], Crohn ’s dise...
Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: H. Alexander, S. de Lusignan, S. Mashayekhi, C. Feeney, C. Flohr Tags: Clinical Research and Epidemiology Source Type: research

Quality improvement of prescribing safety: a pilot study in primary care using UK electronic health records.
CONCLUSION: Electronic health record data can be used to provide standardised, reproducible reports that can be delivered at scale with minimal resource requirements. These can be used in a national QI initiative that impacts directly on patient care. PMID: 31262845 [PubMed - as supplied by publisher] (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - June 30, 2019 Category: Primary Care Authors: Booth HP, Gallagher AM, Mullett D, Carty L, Padmanabhan S, Myles PR, Welburn SJ, Hoghton M, Rafi I, Valentine J Tags: Br J Gen Pract Source Type: research