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Price versus clinical guidelines in primary care statin prescribing: a retrospective cohort study and cost simulation model
CONCLUSIONS: There is potential for large savings for the NHS if new and, whenever possible, ongoing patients are promptly switched to the first medicine that becomes available as generic within a therapeutic class as long as it has similar efficacy to still-patented medicines.PMID:34793261 | DOI:10.1177/01410768211051713 (Source: J R Soc Med AND (has...)
Source: J R Soc Med AND (has... - November 18, 2021 Category: General Medicine Authors: Matias Ortiz De Zarate Emmanouil Mentzakis Simon Ds Fraser Paul Roderick Paul Rutter Carmine Ornaghi Source Type: research

Epidemiology, management and the associated burden of mental health illness, atopic and autoimmune conditions, and common infections in alopecia areata: protocol for an observational study series
Introduction Alopecia areata (AA) is a common cause of immune-mediated non-scarring hair loss. Links between AA and common mental health, autoimmune and atopic conditions, and common infections have previously been described but remain incompletely elucidated and contemporary descriptions of the epidemiology of AA in the UK are lacking. Methods and analysis Retrospective study series using a large population-based cohort (5.2 million) from the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) database, exploring four themes: AA epidemiology, mental health comorbidities, autoimmune...
Source: BMJ Open - November 16, 2021 Category: General Medicine Authors: Harries, M., Macbeth, A. E., Holmes, S., Thompson, A. R., Chiu, W. S., Gallardo, W. R., Messenger, A. G., Tziotzios, C., de Lusignan, S. Tags: Open access, Dermatology Source Type: research

Lower carbohydrate diets for adults with type 2 diabetes
Br J Nutr. 2021 Nov 1:1-6. doi: 10.1017/S0007114521002373. Online ahead of print.ABSTRACTIn May 2021, the Scientific Advisory Committee on Nutrition (SACN) published a risk assessment on lower carbohydrate diets for adults with type 2 diabetes (T2D)(1). The purpose of the report was to review the evidence on 'low'-carbohydrate diets compared with the current UK government advice on carbohydrate intake for adults with T2D. However, since there is no agreed and widely utilised definition of a 'low'-carbohydrate diet, comparisons in the report were between lower and higher carbohydrate diets. SACN's remit is to assess the ris...
Source: The British Journal of Nutrition - November 1, 2021 Category: Nutrition Authors: Mamta Singh Estella S Hung Adrienne Cullum Rachel E Allen Peter J Aggett Pamela Dyson Nita G Forouhi Darren C Greenwood Rachel Pryke Roy Taylor Douglas Twenefour Ruth Waxman Ian S Young Source Type: research

Fast decliner phenotype of chronic obstructive pulmonary disease (COPD): applying machine learning for predicting lung function loss
CONCLUSIONS: In this study, three COPD phenotypes were identified prior to patients being diagnosed with COPD. The reproducibility of those phenotypes in a blind data set following COPD diagnosis suggests their generalisability among different populations.PMID:34716217 | DOI:10.1136/bmjresp-2021-000980 (Source: Respiratory Care)
Source: Respiratory Care - October 30, 2021 Category: Respiratory Medicine Authors: Vasilis Nikolaou Sebastiano Massaro Wolfgang Garn Masoud Fakhimi Lampros Stergioulas David B Price Source Type: research

Institutional influences on the supervision of GP trainees: a documentary analysis
Conclusion: With patient safety paramount, and high-quality training and supervision expected, the hierarchical system outlined by the documents is perhaps unsurprising. However, unintended messages may result: collation of evidence may be prized above quality and trainees may feel unable to raise legitimate concerns. Furthermore, conflicting messages from different institutions illustrate the tensions and complexities of GP supervision. For trainees and supervisors, these inconsistencies could lead to different perspectives and expectations as they interact within the supervisory relationship.PMID:34486946 | DOI:10.1080/1...
Source: Education for Primary Care - September 6, 2021 Category: Primary Care Authors: Dawn Jackson Ian Davison Josephine Brady Source Type: research

Institutional influences on the supervision of GP trainees: a documentary analysis
Conclusion: With patient safety paramount, and high-quality training and supervision expected, the hierarchical system outlined by the documents is perhaps unsurprising. However, unintended messages may result: collation of evidence may be prized above quality and trainees may feel unable to raise legitimate concerns. Furthermore, conflicting messages from different institutions illustrate the tensions and complexities of GP supervision. For trainees and supervisors, these inconsistencies could lead to different perspectives and expectations as they interact within the supervisory relationship.PMID:34486946 | DOI:10.1080/1...
Source: Primary Care - September 6, 2021 Category: Primary Care Authors: Dawn Jackson Ian Davison Josephine Brady Source Type: research