Clinical Ontologies Improve Case Finding of Primary Biliary Cholangitis in UK Primary and Secondary Care

ConclusionsUtilization of the UK National RCGP RSC database supported by novel ontology score has successfully helped us identify (i) new cases of PBC not known to local/regional secondary care providers and (ii) de novo PBC cases. There are many PBC probable cases whose data merit further careful evaluation.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research

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Patients with non-alcoholic fatty liver disease (NAFLD) and increased liver-fibrosis scores experience more severe illness from COVID-19, according to a study of Chinese patients.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Gastroenterology News Source Type: news
IFN-α2b inhibits the ethanol enriched-HBV cccDNA through blocking a positive feedback loop of HBx/MSL2/cccDNA/HBV/HBx in liver. Biochem Biophys Res Commun. 2020 Jun 18;527(1):76-82 Authors: Liu Z, Wang J, Yuan H, Liu L, Bu Y, Zhao M, Yang G, Feng J, Liu Y, Li J, He Q, Zhang X Abstract Hepatitis B virus (HBV) is a major risk factor for liver diseases, in which HBV covalently closed circular DNA (cccDNA), as the genomic form that templates viral transcription, plays crucial roles in sustaining viral persistence. Clinically, the excessive ethanol intake accelerates the progression of liver diseases...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC2) is a rare congenital cholestatic liver disease that progresses to end stage liver disease. It is associated with fat soluble vitamin D deficiency ri...
Source: International Journal of Pediatric Endocrinology - Category: Endocrinology Authors: Tags: Case report Source Type: research
In this study, next-generation sequence (NGS) is utilized by applying OncoSNP-SEQ technique to a number of human chromosomes for analyzing hepatic cancer data that identify genome-wide mutations in copy number of the genomic information data. The outcomes referred to a certain number of chromosome aberrations detected with significant genes such as: SHC, TCP1, CCT3,SHC1, EPHA5, UGT2B28, UBE1L2, and also strike (CREB3L4, RAB1, MAGI2) genes which are discovered lately in 2013, tumor suppressorsSHC1 andCKS1B, LRP1B, as well as oncogeneUBE1L2, all of which may play a central role in cancer cell survival during the progress of ...
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - Category: Bioinformatics Source Type: research
We read with great interest the review by Tr épo and Valenti on recent developments in genetics of NAFLD,1 which highlighted the need for further confirmation of the association between the rs2642438 (p.A165T) variant in the mitochondrial amidoxime reducing component 1 (MARC1) gene and liver disease risk. This missense variant was recently sh own to associate with protection from all-cause cirrhosis.2 MARC1 encodes for a molybdenum-containing enzyme in the outer mitochondrial membrane, which has reductive activity for N-hydroxylated compounds, e.g.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Alcohol-related liver disease (ALD) accounts for the majority of cirrhosis and liver-related deaths worldwide. Activation of IFN-regulatory factor (IRF3) initiates alcohol-induced hepatocyte apoptosis, which fuels a robust secondary inflammatory response that drives ALD. The dominant molecular mechanism by which alcohol activates IRF3 and the pathways that amplify inflammatory signals in...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Acute on chronic liver failure (ACLF) is an inflammation-based disorder that occurs in patients with underlying liver disease and is characterized by hepatic and extrahepatic organ failure. Morbidity and mortality are high in patients with ACLF, and therefore prevention and early identification are critical to improve outcome. The purpose of this article is to define ACLF, describe ways to identify the expected outcome of ACLF after development, and illustrate interventions to prevent it and when it is not preventable reduce associated morbidity and mortality.
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This article defines HBV reactivation, discusses risk stratification and common medications that can induce HBV reactivation as well as guideline recommendations for prevention of HBV reactivation, and describes the prognosis and management of patients who experience HBV reactivation.
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Condition:   Non-Alcoholic Fatty Liver Disease Intervention:   Other: Dietary intervention Sponsors:   Rabin Medical Center;   Hebrew University of Jerusalem Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Alcoholic Liver Disease Intervention:   Sponsor:   University Hospital, Lille Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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