Aspirin and Pravastatin for Preeclampsia Prevention in High-Risk Pregnancy
Preeclampsia is a hypertensive disorder of pregnancy affecting up to 8% of pregnancies. It is associated with significant neonatal and maternal morbidities and mortality. Although its pathogenesis is not completely understood, abnormal placentation resulting in imbalance in angiogenic factors, increased inflammation, and endothelial dysfunction are thought to be key pathways in the development of the disease. Administration of low-dose aspirin is recommended by professional societies for the prevention of preeclampsia in high-risk individuals. In this review, we summarize the evidence behind the use of low-dose aspirin and...
Source: Obstetrics and Gynecology Clinics - February 22, 2023 Category: OBGYN Authors: Joe Eid, Kara M. Rood, Maged M. Costantine Source Type: research
Pravastatin for severe preeclampsia with growth restriction: Placental findings and infant follow-up
CONCLUSIONS: Our data did not allow us to find significant differences in pregnancy outcome and infant follow-up, as well as in placental histological picture in preeclamptic patients when pravastatin is administered in the late second trimester. However, we suggest its possible role in stabilizing the disease, increasing the prenatal weight gain and prolonging the duration of pregnancy, thus preventing the progression to a more severe maternal disease.PMID:36764034 | DOI:10.1016/j.ejogrb.2023.01.036 (Source: Reproductive Biology)
Source: Reproductive Biology - February 10, 2023 Category: Reproduction Medicine Authors: Stefano Fruci Silvia Salvi Sascia Moresi Francesca Gallini Marco Dell'Aquila Vincenzo Arena Enrico Di Stasio Sergio Ferrazzani Sara De Carolis Antonio Lanzone Source Type: research
The Effect of Statin Therapy on Serum Uric Acid Levels: A Systematic Review and Meta-Analysis
CONCLUSION: Statins were significantly associated with a decrease in SUA levels, particularly atorvastatin, which was found to be most effective in lowering SUA. Atorvastatin may be the most appropriate cholesterol-lowering agent for patients with or at risk of hyperuricemia.PMID:36748810 | DOI:10.2174/0929867330666230207124516 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 7, 2023 Category: Chemistry Authors: Abolfazl Akbari Mahya Razmi Mahdi Rafiee Gerald F Watts Amirhossein Sahebkar Source Type: research
The Effect of Statin Therapy on Serum Uric Acid Levels: A Systematic Review and Meta-Analysis
CONCLUSION: Statins were significantly associated with a decrease in SUA levels, particularly atorvastatin, which was found to be most effective in lowering SUA. Atorvastatin may be the most appropriate cholesterol-lowering agent for patients with or at risk of hyperuricemia.PMID:36748810 | DOI:10.2174/0929867330666230207124516 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - February 7, 2023 Category: Chemistry Authors: Abolfazl Akbari Mahya Razmi Mahdi Rafiee Gerald F Watts Amirhossein Sahebkar Source Type: research
Pravastatin For Severe Preeclampsia With Growth Restriction: Placental Findings And Infant Follow-Up
Preeclampsia (PE) is the major cause of maternal and fetal death and the leading cause of premature delivery worldwide. Even today, the definitive therapy remains the delivery with the removal of the placenta and although delivery is always beneficial for the mother, it may not be optimal for the fetus, as it might be extremely premature. It occurs in 2% to 8% of pregnancies worldwide1 and is defined as a syndrome since it is a multisystemic disorder. Preeclampsia is thought to be due to placental malperfusion resulting from abnormal remodeling of maternal spiral arteries that leads to placental dysfunction and endothelial...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2023 Category: OBGYN Authors: Stefano Fruci, Silvia Salvi, Sascia Moresi, Francesca Gallini, Marco Dell'Aquila, Vincenzo Arena, Enrico Di Stasio, Sergio Ferrazzani, Sara De Carolis, Antonio Lanzone Tags: Full length article Source Type: research
High- vs. Low-Intensity Statin Therapy and Changes in Coronary Artery Calcification Density after One Year
CONCLUSION: HIST vs. LIST leads to a higher reduction in cholesterol levels, which does not translate into relevant differences in the change of CAC density at one-year follow-up.PMID:36675405 | DOI:10.3390/jcm12020476 (Source: Medical History)
Source: Medical History - January 21, 2023 Category: History of Medicine Authors: Lukas Hermann Vogel Iryna Dykun Paolo Raggi Axel Schmermund Tienush Rassaf Amir Abbas Mahabadi Source Type: research
High- vs. Low-Intensity Statin Therapy and Changes in Coronary Artery Calcification Density after One Year
CONCLUSION: HIST vs. LIST leads to a higher reduction in cholesterol levels, which does not translate into relevant differences in the change of CAC density at one-year follow-up.PMID:36675405 | DOI:10.3390/jcm12020476 (Source: Medical History)
Source: Medical History - January 21, 2023 Category: History of Medicine Authors: Lukas Hermann Vogel Iryna Dykun Paolo Raggi Axel Schmermund Tienush Rassaf Amir Abbas Mahabadi Source Type: research
High- vs. Low-Intensity Statin Therapy and Changes in Coronary Artery Calcification Density after One Year
CONCLUSION: HIST vs. LIST leads to a higher reduction in cholesterol levels, which does not translate into relevant differences in the change of CAC density at one-year follow-up.PMID:36675405 | PMC:PMC9867203 | DOI:10.3390/jcm12020476 (Source: Medical History)
Source: Medical History - January 21, 2023 Category: History of Medicine Authors: Lukas Hermann Vogel Iryna Dykun Paolo Raggi Axel Schmermund Tienush Rassaf Amir Abbas Mahabadi Source Type: research
The Case | Hyperammonemia in a non-cirrhotic hemodialysis patient
A 78-year-old woman presented with recurrent encephalopathy after hemodialysis initiation. Her medical history included end-stage renal disease, congestive heart failure, and cerebral infarction. Her medication included aspirin, losartan, carvedilol, pravastatin, and lansoprazole. Maintenance hemodialysis was initiated because of refractory volume overload. Two days after dialysis initiation, she was noted to be comatose with hyperammonemia (205 μg/dl). Branched-chain amino acid infusion was administered, resulting in improvement of her mental status. (Source: Kidney International)
Source: Kidney International - January 1, 2023 Category: Urology & Nephrology Authors: Tomoki Taniguchi, Mayumi Tomita, Noriyuki Iehara Tags: Make Your Diagnosis Source Type: research
Selected Statins as Dual Antiproliferative-Antiinflammatory Compounds
CONCLUSION: Among the rest, cerivastatin warrants further novel scaffold development to maximize efficacy and optimal molecular action mechanisms of chemotherapy/prevention.PMID:36579985 | DOI:10.31557/APJCP.2022.23.12.4047 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 29, 2022 Category: Cancer & Oncology Authors: Buchra Haj Hussein Violet Kasabri Yusuf Al-Hiari Shereen Arabiyat Balqis Ikhmais Sundus Alalawi Tariq Al-Qirim Source Type: research
