Differences in the diabetogenic effect of statins in patients with prediabetes. The PRELIPID study
CONCLUSIONS: This study suggests that there are differences in the diabetogenic effect of statins. Simvastatin and high doses of atorvastatin may be associated with greater impairment in glucose metabolism than pitavastatin and other statins with less lipid-lowering potency such as pravastatin.PMID:34517987 | DOI:10.1016/j.medcli.2021.06.018 (Source: Medicina Clinica)
Source: Medicina Clinica - September 14, 2021 Category: General Medicine Authors: Ferran Trias Xavier Pint ó Emili Corbella Manuel Su árez-Tembra Antonio Ru íz-García Jos é Luis Díaz-Díaz Elena S ánchez-Ruíz-Granado Itziar Sarasa Raul Mart ínez-Porqueras Maria Angeles Rodr íguez-Sánchez Xavier Corbella PRELIPID Study Group Source Type: research

Adherence and persistence in the use of statins and ezetimibe over 8 years in a real-life study
CONCLUSION: Adherent patients had a higher persistence than non-adherent patients.PMID:34515600 | DOI:10.1080/03007995.2021.1980777 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 13, 2021 Category: Research Authors: Fiorenzo Santoleri Alessia Romagnoli Alberto Costantini Source Type: research

Assessment of the Effect of Filgotinib on the Pharmacokinetics of Atorvastatin, Pravastatin, and Rosuvastatin in Healthy Adult Participants
AbstractFilgotinib, an oral Janus kinase-1 preferential inhibitor, is approved in Europe and Japan for adults with rheumatoid arthritis. Patients with rheumatoid arthritis are at higher risk of cardiovascular morbidity/mortality; thus, it is important to understand potential drug-drug interactions of filgotinib with lipid-lowering agents. This open-label, randomized, 2-way crossover study evaluated the pharmacokinetics of atorvastatin, pravastatin, and rosuvastatin with and without filgotinib coadministration. Healthy participants (N = 27) received single doses of atorvastatin (40 mg) and of a pravastatin (40 mg)/rosuvasta...
Source: Clinical Pharmacology in Drug Development - September 1, 2021 Category: Drugs & Pharmacology Authors: Kacey Anderson, Cara H. Nelson, Qi Gong, Muhsen Alani, Thomas Tarnowski, Ahmed A. Othman Tags: Original Manuscript Source Type: research

Pravastatin attenuates sepsis-induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of Cav-1/eNOS pathway
CONCLUSION: Pravastatin ameliorates sepsis-induced ALI through improving alveolar endothelial barrier disruption via modulating Cav-1/eNOS pathway, which may be an effective candidate for treating septic ALI.PMID:34464887 | DOI:10.1016/j.intimp.2021.108077 (Source: International Immunopharmacology)
Source: International Immunopharmacology - August 31, 2021 Category: Allergy & Immunology Authors: Yi Ren Liang Li Meng-Meng Wang Li-Ping Cao Zhao-Rui Sun Zhi-Zhou Yang Wei Zhang Peng Zhang Shi-Nan Nie Source Type: research

GSE182829 Analysis of Transcriptome in small intestine after radiation injury with treatment of pravastatin
This study is designed to understand whether Pravastatin (Pra) treatment alters the transcriptome of small intestine after radiation injury. RNA was extracted from 15 Gy abdominal irradiated Gottingen minipigs with PS treatment. A cDNA library was generated using a TruSeq Stranded mRNA sample prep kit (Illumina, San Diego, CA), and transcriptome sequencing was performed using a TruSeq 3000/4000 SBS kit and Illumina sequencer with 101 bp paired-end reads per sample (Macrogen, Seoul, Korea). (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - August 29, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Sus scrofa domesticus Source Type: research

atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity
Conclusions: Our findings suggest that atg7-based autophagy activation is an effective therapeutic avenue to reversing the decline in cardiac function in AIC, highlighting the time dependent nature of autophagy-based therapy.PMID:34384247 | DOI:10.1161/CIRCRESAHA.121.319104 (Source: Circulation Research)
Source: Circulation Research - August 13, 2021 Category: Cardiology Authors: Yong Wang Xiaoguang Lu Xiaoping Wang Qi Qiu Ping Zhu Lin Ma Xiao Ma Joerg Herrmann Xueying Lin Wei Wang Xiaolei Xu Source Type: research

atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity
Conclusions: Our findings suggest that atg7-based autophagy activation is an effective therapeutic avenue to reversing the decline in cardiac function in AIC, highlighting the time dependent nature of autophagy-based therapy.PMID:34384247 | DOI:10.1161/CIRCRESAHA.121.319104 (Source: Circulation Research)
Source: Circulation Research - August 13, 2021 Category: Cardiology Authors: Yong Wang Xiaoguang Lu Xiaoping Wang Qi Qiu Ping Zhu Lin Ma Xiao Ma Joerg Herrmann Xueying Lin Wei Wang Xiaolei Xu Source Type: research

atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity
Conclusions: Our findings suggest that atg7-based autophagy activation is an effective therapeutic avenue to reversing the decline in cardiac function in AIC, highlighting the time dependent nature of autophagy-based therapy.PMID:34384247 | DOI:10.1161/CIRCRESAHA.121.319104 (Source: Circulation Research)
Source: Circulation Research - August 13, 2021 Category: Cardiology Authors: Yong Wang Xiaoguang Lu Xiaoping Wang Qi Qiu Ping Zhu Lin Ma Xiao Ma Joerg Herrmann Xueying Lin Wei Wang Xiaolei Xu Source Type: research

atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity
Conclusions: Our findings suggest that atg7-based autophagy activation is an effective therapeutic avenue to reversing the decline in cardiac function in AIC, highlighting the time dependent nature of autophagy-based therapy.PMID:34384247 | DOI:10.1161/CIRCRESAHA.121.319104 (Source: Circulation Research)
Source: Circulation Research - August 13, 2021 Category: Cardiology Authors: Yong Wang Xiaoguang Lu Xiaoping Wang Qi Qiu Ping Zhu Lin Ma Xiao Ma Joerg Herrmann Xueying Lin Wei Wang Xiaolei Xu Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research

Molecules, Vol. 26, Pages 4685: Detection of 4a,5-dihydropravastatin as Impurity in the Cholesterol Lowering Drug Pravastatin
en Berg Dihydro analogues are known byproducts of the fermentative production of statins and cannot be detected with existing pharmacopoeia analysis methods. We detected dihydropravastatin in most commercial formulations of pravastatin with LC-MS, in some cases in levels requiring identification. In fermentation broth samples of the single step production of pravastatin, we detected and identified for the first time 4a,5-dihydropravastatin, and confirmed that after several recrystallization steps this impurity can be fully removed from the pravastatin powder. (Source: Molecules)
Source: Molecules - August 3, 2021 Category: Chemistry Authors: Wibo B. van Scheppingen Peter P. Lankhorst Marcus Hans Marco A. van den Berg Tags: Article Source Type: research

Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury
This study aimed to assess the modulation of organic anion transporting polypeptide (Oatp) 1a2 and Oatp2b1 expression/function in the small intestine of rats with drug-induced AKI. AKI was induced by intraperitoneal administration of cisplatin at a dose of 5 mg/kg. On day 3 after cisplatin administration, morphological changes in the small intestine, Oatp1a2 and Oatp2b1 expression, and absorption of pravastatin and theophylline were evaluated. Non-negligible atrophy was observed in the jejunum and ileum of the AKI rats. However, the absorption of theophylline was not affected. While intestinal Oatp2b1 expression was marked...
Source: Drug Metabolism and Pharmacokinetics - July 20, 2021 Category: Drugs & Pharmacology Authors: Fuyo Takeda Masako Oda Masaru Terasaki Atsuhito Kubota Keita Asada Yuichi Ichimura Hiroyuki Kojima Hiroshi Saitoh Source Type: research

Effect of folic acid combined with pravastatin on arteriosclerosis in elderly hypertensive patients with lacunar infarction
This study aimed to assess the effect of folic acid combined with pravastatin on atherosclerosis-related indexes in elderly patients with hypertension complicated with lacunar cerebral infarction. A total of 134 elderly hypertensive patients with lacunar cerebral infarction were randomly divided into 3 groups using the random number table method. Group A, the folic acid group, had 45 cases and received low-dose folic acid (0.8 mg/d) treatment on the basis of antihypertensive treatment. Group B, the pravastatin group, had 45 cases and received pravastatin (20 mg/d) treatment on the basis of antihypertensive treatment...
Source: Medicine - July 16, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Pravastatin-Induced Acute Pancreatitis: A Case Report and Literature Review
J Investig Med High Impact Case Rep. 2021 Jan-Dec;9:23247096211028386. doi: 10.1177/23247096211028386.ABSTRACTPancreatitis is inflammation of pancreas associated most commonly with chronic alcoholism and gallstones. Other less common causes of pancreatitis are hyperlipidemia, infections, surgery, trauma, post endoscopic retrograde cholangiopancreatography, and drugs. Drugs are now increasingly recognized as a cause of pancreatitis, and high suspicion and exclusion of other most common causes is required before considering drug-induced pancreatitis. There are few case reports of acute pancreatitis in the literature after st...
Source: Pain Physician - June 28, 2021 Category: Anesthesiology Authors: Zahid Ijaz Tarar Muhammad Usman Zafar Ghulam Ghous Umer Farooq Hafiz Muhammad Hassan Shoukat Source Type: research

Pravastatin versus Placebo in Pregnancies at High Risk of Term Preeclampsia
Conclusions: Pravastatin in women at high risk of term preeclampsia did not reduce the incidence of delivery with preeclampsia. Clinical Trial Registration: URL: https://www.isrctn.com Unique Identifier ISRCTN16123934.PMID:34162218 | DOI:10.1161/CIRCULATIONAHA.121.053963 (Source: Circulation)
Source: Circulation - June 24, 2021 Category: Cardiology Authors: Moritz D öbert Anna Nektaria Varouxaki An Chi Mu Argyro Syngelaki Anca Ciobanu Ranjit Akolekar Catalina De Paco Matallana Simona Cicero Elena Greco Mandeep Singh Deepa Janga Maria Del Mar Gil Jacques C Jani Jos é Luis Bartha Kate Maclagan David Wright K Source Type: research

Pravastatin versus Placebo in Pregnancies at High Risk of Term Preeclampsia
Conclusions: Pravastatin in women at high risk of term preeclampsia did not reduce the incidence of delivery with preeclampsia. Clinical Trial Registration: URL: https://www.isrctn.com Unique Identifier ISRCTN16123934.PMID:34162218 | DOI:10.1161/CIRCULATIONAHA.121.053963 (Source: Circulation)
Source: Circulation - June 24, 2021 Category: Cardiology Authors: Moritz D öbert Anna Nektaria Varouxaki An Chi Mu Argyro Syngelaki Anca Ciobanu Ranjit Akolekar Catalina De Paco Matallana Simona Cicero Elena Greco Mandeep Singh Deepa Janga Maria Del Mar Gil Jacques C Jani Jos é Luis Bartha Kate Maclagan David Wright K Source Type: research

Pravastatin is useful for prevention of recurrent severe placenta-mediated complications – a pilot study
. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - June 22, 2021 Category: Perinatology & Neonatology Authors: Michael J. Kupferminc Chagit Kliger Eli Rimon Jessica Asher-Landsberg Avital Skornick-Rapaport Ronni Gamzu Yariv Yogev Source Type: research

Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N ‐methyltransferase level in endothelial cells
In this study, side effects of pravastatin and atorvastatin on EA.hy926 endothelial cell line were investigated. It was found that both statins activate proinflammatory response, elevate nitric oxide and reactive oxygen species (ROS) generation and stimulate antioxidative response in these cells. Moreover, only slight stimulation of the mitochondrial biogenesis and significant changes in the mitochondrial network organisation have been noted. Although biochemical bases behind these effects are not clear, they may partially be explained as an elevation of AMP-activated protein kinase (AMPK) activity and an increased activat...
Source: Journal of Applied Toxicology - June 10, 2021 Category: Toxicology Authors: Dorota Dymkowska, Antoni Wrzosek, Krzysztof Zab łocki Tags: RESEARCH ARTICLE Source Type: research

In silico interactions of statins with cell death-inducing DNA fragmentation factor-like effector A (CIDEA)
Chem Biol Interact. 2021 May 19:109528. doi: 10.1016/j.cbi.2021.109528. Online ahead of print.ABSTRACTStatins are the low-density lipoproteins (LDL)-cholesterol-lowering drugs of first choice and are used to prevent the increased risk of cardiovascular and cerebrovascular diseases. Although some of their effects are well known, little is known about their ability to regulate other lipid-related proteins which control apoptotic mechanisms. The aim of this study was to explore whether statins can bind to cell death-inducing DNA fragmentation factor-like effector A (CIDEA), which might be a possible pleiotropic mechanism of a...
Source: Mol Biol Cell - May 22, 2021 Category: Molecular Biology Authors: George E Barreto Janneth Gonzalez Željko Reiner Tannaz Jamialahmadi Valentina Echeverria Ghulam Md Ashraf Amirhossein Sahebkar Source Type: research

In silico interactions of statins with cell death-inducing DNA fragmentation factor-like effector A (CIDEA)
Chem Biol Interact. 2021 May 19:109528. doi: 10.1016/j.cbi.2021.109528. Online ahead of print.ABSTRACTStatins are the low-density lipoproteins (LDL)-cholesterol-lowering drugs of first choice and are used to prevent the increased risk of cardiovascular and cerebrovascular diseases. Although some of their effects are well known, little is known about their ability to regulate other lipid-related proteins which control apoptotic mechanisms. The aim of this study was to explore whether statins can bind to cell death-inducing DNA fragmentation factor-like effector A (CIDEA), which might be a possible pleiotropic mechanism of a...
Source: Chemico-Biological Interactions - May 22, 2021 Category: Molecular Biology Authors: George E Barreto Janneth Gonzalez Željko Reiner Tannaz Jamialahmadi Valentina Echeverria Ghulam Md Ashraf Amirhossein Sahebkar Source Type: research

A Randomized Pilot Clinical Trial of Pravastatin Versus Placebo in Pregnant Patients at High-Risk of Preeclampsia
Preeclampsia remains a major cause of maternal and neonatal morbidity and mortality. Biological plausibility, compelling preliminary data, and a pilot clinical trial support the safety and utility of pravastatin to prevent preeclampsia. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 21, 2021 Category: OBGYN Authors: Maged M. Costantine, Holly West, Katherine L. Wisner, Steve Caritis, Shannon Clark, Raman Venkataramanan, Catherine S. Stika, Erik Rytting, Xiaoming Wang, Mahmoud S. Ahmed, Eunice Kennedy Shriver National Institute of Child Health and Human Development Ob Tags: Original Research: Obstetrics Source Type: research

A randomized pilot clinical trial of pravastatin versus placebo in pregnant patients at high risk of preeclampsia
Preeclampsia remains a major cause of maternal and neonatal morbidity and mortality. Biologic plausibility, compelling preliminary data, and a pilot clinical trial support the safety and utility of pravastatin for the prevention of preeclampsia. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 21, 2021 Category: OBGYN Authors: Maged M. Costantine, Holly West, Katherine L. Wisner, Steve Caritis, Shannon Clark, Raman Venkataramanan, Catherine S. Stika, Erik Rytting, Xiaoming Wang, Mahmoud S. Ahmed, Eunice Kennedy Shriver National Institute of Child Health and Human Development Ob Tags: Original Research Source Type: research

Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy
Cardiol Res Pract. 2021 Apr 29;2021:6621925. doi: 10.1155/2021/6621925. eCollection 2021.ABSTRACTHerbal medicine unswervingly serves human health by modernizing preparation and administration. Coronary artery atherosclerosis is a serious threat to human health and survival all over the world. Following experimental and clinical evidence, we collected four herbal treatments containing herbal strategy I (San Qi), II (Injectio Salvia Miltiorrhizae), III (Danhong injection), and IV (Taoren Honghua Jian granule) against coronary artery disease. In order to analyze their similarities and differences in controlling coronary arter...
Source: Cardiology Research and Practice - May 20, 2021 Category: Cardiology Authors: Yu Cao Yang Liu Tian Zhang Wei Lei Boli Zhang Source Type: research

Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy
Cardiol Res Pract. 2021 Apr 29;2021:6621925. doi: 10.1155/2021/6621925. eCollection 2021.ABSTRACTHerbal medicine unswervingly serves human health by modernizing preparation and administration. Coronary artery atherosclerosis is a serious threat to human health and survival all over the world. Following experimental and clinical evidence, we collected four herbal treatments containing herbal strategy I (San Qi), II (Injectio Salvia Miltiorrhizae), III (Danhong injection), and IV (Taoren Honghua Jian granule) against coronary artery disease. In order to analyze their similarities and differences in controlling coronary arter...
Source: Cardiology Research and Practice - May 20, 2021 Category: Cardiology Authors: Yu Cao Yang Liu Tian Zhang Wei Lei Boli Zhang Source Type: research

Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy
Cardiol Res Pract. 2021 Apr 29;2021:6621925. doi: 10.1155/2021/6621925. eCollection 2021.ABSTRACTHerbal medicine unswervingly serves human health by modernizing preparation and administration. Coronary artery atherosclerosis is a serious threat to human health and survival all over the world. Following experimental and clinical evidence, we collected four herbal treatments containing herbal strategy I (San Qi), II (Injectio Salvia Miltiorrhizae), III (Danhong injection), and IV (Taoren Honghua Jian granule) against coronary artery disease. In order to analyze their similarities and differences in controlling coronary arter...
Source: Cardiology Research and Practice - May 20, 2021 Category: Cardiology Authors: Yu Cao Yang Liu Tian Zhang Wei Lei Boli Zhang Source Type: research