Mutant p53 murine oviductal epithelial cells induce progression of high-grade serous carcinoma and are most sensitive to simvastatin therapy in vitro and in vivo
This study suggests that simvastatin can induce anti-tumor effects and could be an important inhibitor of ovarian cancer progression.PMID:37986175 | DOI:10.1186/s13048-023-01307-x (Source: Cell Research)
Source: Cell Research - November 21, 2023 Category: Cytology Authors: Madison Pereira Alice Glogova Jacob Haagsma Julia Stewart Trevor G Shepherd Jim Petrik Source Type: research
Challenges in Conducting Clinical Trials for Preeclampsia
AbstractPurpose of ReviewTo review recent data describing the challenges and innovations in therapeutic research focused on the prevention and treatment of preeclampsia.Recent FindingsPregnant individuals have traditionally been excluded from therapeutic research, resulting in a paucity of innovation in therapeutics for pregnancy-specific medical conditions, especially preeclampsia. With the increased awareness of maternal morbidity and mortality, there is significant interest among researchers to expand therapeutic research in pregnancy. Several medications, including aspirin, pravastatin, metformin, and esomeprazole, whi...
Source: Current Hypertension Reports - November 16, 2023 Category: Primary Care Source Type: research
