Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
Acta Pharm. 2024 Mar 30;74(1):117-130. doi: 10.2478/acph-2024-0001. Print 2024 Mar 1.ABSTRACTStatin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, ...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Hacer Kayhan Kaya Berjan Demirtas Beran Yokus Dilek Ayg ün Kesim Ezel Tasdemir Abdurrahman Sermet Source Type: research
Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
Acta Pharm. 2024 Mar 30;74(1):117-130. doi: 10.2478/acph-2024-0001. Print 2024 Mar 1.ABSTRACTStatin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, ...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Hacer Kayhan Kaya Berjan Demirtas Beran Yokus Dilek Ayg ün Kesim Ezel Tasdemir Abdurrahman Sermet Source Type: research
Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
Acta Pharm. 2024 Mar 30;74(1):117-130. doi: 10.2478/acph-2024-0001. Print 2024 Mar 1.ABSTRACTStatin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, ...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Hacer Kayhan Kaya Berjan Demirtas Beran Yokus Dilek Ayg ün Kesim Ezel Tasdemir Abdurrahman Sermet Source Type: research
Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
Acta Pharm. 2024 Mar 30;74(1):117-130. doi: 10.2478/acph-2024-0001. Print 2024 Mar 1.ABSTRACTStatin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, ...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Hacer Kayhan Kaya Berjan Demirtas Beran Yokus Dilek Ayg ün Kesim Ezel Tasdemir Abdurrahman Sermet Source Type: research
Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
Acta Pharm. 2024 Mar 30;74(1):117-130. doi: 10.2478/acph-2024-0001. Print 2024 Mar 1.ABSTRACTStatin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, ...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Hacer Kayhan Kaya Berjan Demirtas Beran Yokus Dilek Ayg ün Kesim Ezel Tasdemir Abdurrahman Sermet Source Type: research
Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
Acta Pharm. 2024 Mar 30;74(1):117-130. doi: 10.2478/acph-2024-0001. Print 2024 Mar 1.ABSTRACTStatin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, ...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Hacer Kayhan Kaya Berjan Demirtas Beran Yokus Dilek Ayg ün Kesim Ezel Tasdemir Abdurrahman Sermet Source Type: research
Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
Acta Pharm. 2024 Mar 30;74(1):117-130. doi: 10.2478/acph-2024-0001. Print 2024 Mar 1.ABSTRACTStatin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, ...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Hacer Kayhan Kaya Berjan Demirtas Beran Yokus Dilek Ayg ün Kesim Ezel Tasdemir Abdurrahman Sermet Source Type: research
Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
Acta Pharm. 2024 Mar 30;74(1):117-130. doi: 10.2478/acph-2024-0001. Print 2024 Mar 1.ABSTRACTStatin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, ...
Source: Acta Pharmaceutica - March 30, 2024 Category: Drugs & Pharmacology Authors: Hacer Kayhan Kaya Berjan Demirtas Beran Yokus Dilek Ayg ün Kesim Ezel Tasdemir Abdurrahman Sermet Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research
