Pravastatin For Severe Preeclampsia With Growth Restriction: Placental Findings And Infant Follow-Up

Preeclampsia (PE) is the major cause of maternal and fetal death and the leading cause of premature delivery worldwide. Even today, the definitive therapy remains the delivery with the removal of the placenta and although delivery is always beneficial for the mother, it may not be optimal for the fetus, as it might be extremely premature. It occurs in 2% to 8% of pregnancies worldwide1 and is defined as a syndrome since it is a multisystemic disorder. Preeclampsia is thought to be due to placental malperfusion resulting from abnormal remodeling of maternal spiral arteries that leads to placental dysfunction and endothelial injury that eventually manifest as maternal hypertension and end-organ injury2.

Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2023 Category: OBGYN Authors: Stefano Fruci, Silvia Salvi, Sascia Moresi, Francesca Gallini, Marco Dell'Aquila, Vincenzo Arena, Enrico Di Stasio, Sergio Ferrazzani, Sara De Carolis, Antonio Lanzone Tags: Full length article Source Type: research