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Long-term outcome in Vaccine-induced Immune Thrombocytopenia and Thrombosis
CONCLUSION: Once the acute episode of VITT has passed, patients appear to be at low risk for recurrent thrombosis and/or thrombocytopenia.PMID:37394120 | DOI:10.1016/j.jtha.2023.06.027 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 2, 2023 Category: Hematology Authors: Linda Sch önborn Sabrina E Seck Thomas Thiele Lars Kaderali Till Hoffmann Annalena Hlinka Edelgard Lindhoff-Last Uwe V ölker Kathleen Selleng Alessandra Buoninfante Marco Cavaleri Andreas Greinacher Source Type: research

Coordinated global cessation of oral poliovirus vaccine use: Options and potential consequences
AbstractDue to the very low, but nonzero, paralysis risks associated with the use of oral poliovirus vaccine (OPV), eradicating poliomyelitis requires ending all OPV use globally. The Global Polio Eradication Initiative (GPEI) coordinated cessation of Sabin type 2 OPV (OPV2 cessation) in 2016, except for emergency outbreak response. However, as of early 2023, plans for cessation of bivalent OPV (bOPV, containing types 1 and 3 OPV) remain undefined, and OPV2 use for outbreak response continues due to ongoing transmission of type 2 polioviruses and reported type 2 cases. Recent development and use of a genetically stabilized...
Source: Risk Analysis - June 22, 2023 Category: International Medicine & Public Health Authors: Dominika A. Kalkowska, Steven G. F. Wassilak, Eric Wiesen, Cara C. Burns, Mark A. Pallansch, Kamran Badizadegan, Kimberly M. Thompson Tags: ORIGINAL ARTICLE Source Type: research

Worst ‐case scenarios: Modeling uncontrolled type 2 polio transmission
AbstractIn May 2016, the Global Polio Eradication Initiative (GPEI) coordinated the cessation of all use of type 2 oral poliovirus vaccine (OPV2), except for emergency outbreak response. Since then, paralytic polio cases caused by type 2 vaccine-derived polioviruses now exceed 3,000 cases reported by 39 countries. In 2022 (as of April 25, 2023), 20 countries reported detection of cases and nine other countries reported environmental surveillance detection, but no reported cases. Recent development of a genetically modified novel type 2 OPV (nOPV2) may help curb the generation of neurovirulent vaccine-derived strains; its u...
Source: Risk Analysis - June 22, 2023 Category: International Medicine & Public Health Authors: Dominika A. Kalkowska, Eric Wiesen, Steven G. F. Wassilak, Cara C. Burns, Mark A. Pallansch, Kamran Badizadegan, Kimberly M. Thompson Tags: ORIGINAL ARTICLE Source Type: research

Daily briefing: Vaginal seeding seems to benefit babies delivered by caesarean section
Nature, Published online: 16 June 2023; doi:10.1038/d41586-023-02044-3Mum’s microbes might boost brain development of c-section babies. Plus, volunteers got infected with COVID to help understand supershedders and upgraded polio vaccines could help stamp out the disease forever. (Source: Nature AOP)
Source: Nature AOP - June 16, 2023 Category: Research Authors: Flora Graham Source Type: research

Polio endgame finish is in sight
Nature, Published online: 14 June 2023; doi:10.1038/d41586-023-01773-9Efforts to eradicate polio globally have been under way for more than 35 years. The development of modified versions of a vaccine in current use now makes eradication a real possibility. (Source: Nature AOP)
Source: Nature AOP - June 14, 2023 Category: Research Authors: Alan D. T. Barrett Source Type: research

Vaccine-derived polio is undermining the fight to eradicate the virus
Nature, Published online: 14 June 2023; doi:10.1038/d41586-023-01953-7Wild polio has almost been eradicated, but vaccine-derived strains retain the potential to paralyse. Better vaccines have arrived — but they are only part of the answer. (Source: Nature AOP)
Source: Nature AOP - June 14, 2023 Category: Research Source Type: research

In Africa, doubts about vaccines grew during pandemic, survey finds
Public confidence in vaccines has declined across sub-Saharan Africa since the COVID-19 pandemic, new research shows. A survey of 17,000 people in eight African nations found that the share of respondents agreeing with the statement that “vaccines are important for children” dropped by up to 20 percentage points from 2020 to 2022. The survey also revealed growing doubts about the safety and effectiveness of COVID-19 vaccines and other immunizations in some nations and subnational regions. The trends represent “an early warning signal” for efforts to widely vaccinate children and adults, says Charles She...
Source: Science of Aging Knowledge Environment - June 12, 2023 Category: Geriatrics Source Type: research

Surveillance To Track Progress Toward Poliomyelitis Eradication - Worldwide, 2021-2022
This report updates previous reports (7,9) to describe surveillance performance during 2021-2022 in 34 priority countries.* In 2022, a total of 26 (76.5%) priority countries met the two key AFP surveillance performance indicator targets nationally compared with 24 (70.6%) countries in 2021; however, substantial gaps remain in subnational areas. Environmental surveillance expanded to 725 sites in priority countries, a 31.1% increase from the 553 sites reported in 2021. High-quality surveillance is critical to rapidly detect poliovirus transmission and enable prompt poliovirus outbreak response to stop circulation. Frequent ...
Source: MMWR Morb Mortal Wkl... - June 8, 2023 Category: Epidemiology Authors: Tasha Stehling-Ariza Amanda L Wilkinson Ousmane M Diop Jaume Jorba Humayun Asghar Tigran Avagnan Varja Grabovac Ticha Johnson Sudhir Joshi Anfumbom K W Kfutwah Lucky Sangal Salmaan Sharif Ashraf Wahdan Graham F Tallis Stephanie D Kovacs Source Type: research