An inactivated whole-virion vaccine for Enterovirus D68 adjuvanted with CpG ODN or AddaVax elicits potent protective immunity in mice
Vaccine. 2024 Mar 11:S0264-410X(24)00303-7. doi: 10.1016/j.vaccine.2024.03.016. Online ahead of print.ABSTRACTEnterovirus D68 (EV-D68), a pathogen that causes respiratory symptoms, mainly in children, has been implicated in acute flaccid myelitis, which is a poliomyelitis-like paralysis. Currently, there are no licensed vaccines or treatments for EV-D68 infections. Here, we investigated the optimal viral inactivation reagents, vaccine adjuvants, and route of vaccination in mice to optimize an inactivated whole-virion (WV) vaccine against EV-D68. We used formalin, β-propiolactone (BPL), and hydrogen peroxide as viral inact...
Source: Vaccine - March 12, 2024 Category: Allergy & Immunology Authors: Kota Senpuku Chikako Kataoka-Nakamura Yuta Kunishima Toshiro Hirai Yasuo Yoshioka Source Type: research
Prevalence of vaccine-derived poliovirus in sewage waters in Maiduguri, Borno State, Nigeria
Infez Med. 2024 Mar 1;32(1):90-98. doi: 10.53854/liim-3201-12. eCollection 2024.ABSTRACTAfter a long global battle with wild poliovirus, the virus has been defeated through researches and vaccination using the oral polio vaccine and inactivated polio vaccine as well as sensitization. The issue that is now of global concern is that of vaccine-derived poliovirus which emerged from the unstable oral polio vaccine. Ninety sewage water samples were collected from slums in Maiduguri using grab method, concentrated using two phase separation method and subjected to intratypic differentiation and vaccine-derived poliovirus screeni...
Source: Infezioni in Medicina - March 8, 2024 Category: Infectious Diseases Authors: Sakinatu Buba Bislava Aliyu Daja Bamidele Soji Oderinde Sani Muhammad Uzairu Source Type: research
