Chitosan-LeoA-DNA Nanoparticles Promoted the Efficacy of Novel LeoA-DNA Vaccination on Mice Against Helicobacter pylori
In this study, recombinant plasmids containing the LeoA gene of H. pylori are created and conjugated with chitosan nanoparticle (CSNP) to immunize BALB/c mice against the H. pylori infection. We used the online Vaxign tool to analyze the genomes of five distinct strains of H. pylori, and we chose the outer membrane as a prospective vaccine candidate. Afterward, the proteins' immunogenicity was evaluated. The DNA vaccine was constructed and then encapsulated in CSNPs. The effectiveness of the vaccine's immunoprotective effects was evaluated in BALB/c mice. Purified activated splenic CD3+ T cells are used to test the antican...
Source: Current Microbiology - April 1, 2024 Category: Microbiology Authors: Zahra Ahmadzadeh Chaleshtori Ali Asghar Rastegari Hashem Nayeri Abbas Doosti Source Type: research
< em > Helicobacter pylori < /em > and Gastrointestinal Cancers: Recent Advances and Controversies
Clin Med Insights Oncol. 2024 Mar 28;18:11795549241234637. doi: 10.1177/11795549241234637. eCollection 2024.ABSTRACTHelicobacter pylori (H pylori), a gastric bacterium, has been extensively studied for its association with gastritis, peptic ulcers, and gastric cancer. However, recent evidence suggests its potential implications beyond the stomach, linking it to other gastrointestinal malignancies, such as esophageal cancer, liver cancer, pancreatic cancer, gallbladder cancer, and colorectal cancer. In light of the expanding research landscape and the increasing interest in exploring H pylori broader role in gastrointestina...
Source: Clinical Colorectal Cancer - April 1, 2024 Category: Cancer & Oncology Authors: Chuandong Zhang Yuqi Chen Yan Long Huimin Zheng Jiyong Jing Wensheng Pan Source Type: research
Chitosan-LeoA-DNA Nanoparticles Promoted the Efficacy of Novel LeoA-DNA Vaccination on Mice Against Helicobacter pylori
In this study, recombinant plasmids containing the LeoA gene of H. pylori are created and conjugated with chitosan nanoparticle (CSNP) to immunize BALB/c mice against the H. pylori infection. We used the online Vaxign tool to analyze the genomes of five distinct strains of H. pylori, and we chose the outer membrane as a prospective vaccine candidate. Afterward, the proteins' immunogenicity was evaluated. The DNA vaccine was constructed and then encapsulated in CSNPs. The effectiveness of the vaccine's immunoprotective effects was evaluated in BALB/c mice. Purified activated splenic CD3+ T cells are used to test the antican...
Source: Current Microbiology - April 1, 2024 Category: Microbiology Authors: Zahra Ahmadzadeh Chaleshtori Ali Asghar Rastegari Hashem Nayeri Abbas Doosti Source Type: research
Profiling of Metabolites in a Fermented Soy Dietary Supplement Reinforces its Role in the Management of Intestinal Inflammation
ConclusionThe identification of bioactive molecules, such as genistein and SCFAs, capable of modulating anti-inflammatory signaling cascades in the stomach's gastric and neuroendocrine tissues can explain the reported biological effects in GAD and is supported by in vivo data. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - March 25, 2024 Category: Food Science Authors: Richard Ethier,
Arun Krishnamurthy,
Michael Jeffrey,
Thomas A. Tompkins Tags: Research Article Source Type: research
Recurrent Duodenal Ulceration – More Than Simple Peptic Ulcer Disease?
(Source: Gastroenterology)
Source: Gastroenterology - March 24, 2024 Category: Gastroenterology Authors: Govind Kallumkal, Justin McCallen, Michael Contarino Tags: Electronic Gastro Curbside Consult Source Type: research
Recurrent Duodenal Ulceration —More Than Simple Peptic Ulcer Disease?
Question: A 77-year-old man with a pertinent medical history of dementia, recurrent small bowel obstruction resulting in small bowel resection secondary to intraabdominal adhesions related to a previous hernia repair resulting in small bowel resection, and nonsteroidal antiinflammatory drug (NSAID) –associated peptic ulcer disease presented with sharp epigastric abdominal pain, nausea, watery nonbloody diarrhea (approximately 4 bowel movements daily), weight loss, and intolerance to oral intake. Before admission, his medication regimen was 40 mg oral omeprazole daily, 1 g metformin twice dai ly, 1000 U cholecalciferol da...
Source: Gastroenterology - March 24, 2024 Category: Gastroenterology Authors: Govind Kallumkal, Justin McCallen, Michael Contarino Tags: Electronic Curbside Consult Source Type: research
Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children
CONCLUSION: Gastrointestinal CEUS has a high coincidence rate in the diagnosis of peptic ulcer in children, and can be used as a preliminary examination method.PMID:38515948 | PMC:PMC10950618 | DOI:10.3748/wjg.v30.i7.705 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Yu-Hua Zhang Zhi-Hua Xu Shuang-Shuang Ni Hong-Xia Luo Source Type: research
